Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   I6H77_RS00595 Genome accession   NZ_CP066021
Coordinates   123547..124221 (-) Length   224 a.a.
NCBI ID   WP_000590630.1    Uniprot ID   A0A4V0BT06
Organism   Streptococcus oralis strain FDAARGOS_1020     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 118547..129221
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H77_RS00570 (I6H77_00570) - 118680..119609 (-) 930 WP_000411177.1 peptidase U32 family protein -
  I6H77_RS00575 (I6H77_00575) - 119735..120415 (-) 681 WP_000209232.1 ABC transporter ATP-binding protein -
  I6H77_RS00580 (I6H77_00580) - 120429..121484 (-) 1056 WP_000280278.1 ABC transporter permease -
  I6H77_RS00585 (I6H77_00585) - 121871..122155 (+) 285 WP_001276162.1 DUF3270 domain-containing protein -
  I6H77_RS00590 (I6H77_00590) ciaH 122220..123557 (-) 1338 WP_000482347.1 sensor histidine kinase Regulator
  I6H77_RS00595 (I6H77_00595) ciaR 123547..124221 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  I6H77_RS00600 (I6H77_00600) - 124331..126877 (-) 2547 WP_001149145.1 M1 family metallopeptidase -
  I6H77_RS00605 (I6H77_00605) - 126999..127439 (-) 441 WP_000188823.1 ASCH domain-containing protein -
  I6H77_RS00610 (I6H77_00610) - 127436..128284 (-) 849 WP_001245872.1 putative PEP-binding protein -
  I6H77_RS00615 (I6H77_00615) - 128262..128762 (-) 501 WP_000403333.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25479.29 Da        Isoelectric Point: 4.2660

>NTDB_id=516431 I6H77_RS00595 WP_000590630.1 123547..124221(-) (ciaR) [Streptococcus oralis strain FDAARGOS_1020]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=516431 I6H77_RS00595 WP_000590630.1 123547..124221(-) (ciaR) [Streptococcus oralis strain FDAARGOS_1020]
ATGATAAAAATCTTATTAGTAGAAGATGACCTGGGTCTGTCAAACTCAGTATTTGACTTTTTGGATGATTTTGCAGATGT
CATGCAGGTTTTTGATGGAGAAGAAGGTCTCTACGAAGCAGAAAGTGGCGTTTATGACTTGATTTTGCTTGACCTGATGT
TGCCTGAAAAAAATGGTTTCCAAGTCTTGAAAGAATTGCGTGAGAAAGGAATCACGACACCAGTTCTTATCATGACTGCT
AAGGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCGGATGACTACCTCACCAAACCTTTCTATCTAGAAGA
ACTCAAAATGCGGATCCAAGCCCTTCTCAAACGTTCAGGTAAATTTAACGAAAACACCTTAACCTATGGGGATATTGTCG
TCAACCTTTCAACGAATGAAGTGAAAGTGGAAGATACTCCTGTAGAACTACTCGGAAAAGAGTTTGAGTTATTGGTTTAT
TTCCTTCAAAATCAAAATGTTATTCTTCCCAAGACGCAAATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACGAT
TTCCGTTGTAGAAGTCTATGTCTCAAAAGTTCGTAAGAAATTGAAGGGAACAGCCTTTGCTGAAAATCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4V0BT06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

97.768

100

0.978
  ciaR Streptococcus pneumoniae D39

97.768

100

0.978
  ciaR Streptococcus pneumoniae R6

97.768

100

0.978
  ciaR Streptococcus pneumoniae Rx1

97.768

100

0.978
  ciaR Streptococcus mutans UA159

87.5

100

0.875
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366