Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   I6H77_RS00590 Genome accession   NZ_CP066021
Coordinates   122220..123557 (-) Length   445 a.a.
NCBI ID   WP_000482347.1    Uniprot ID   A0A7H9FD82
Organism   Streptococcus oralis strain FDAARGOS_1020     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 117220..128557
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H77_RS00565 (I6H77_00565) rpiA 117891..118574 (-) 684 WP_000429279.1 ribose-5-phosphate isomerase RpiA -
  I6H77_RS00570 (I6H77_00570) - 118680..119609 (-) 930 WP_000411177.1 peptidase U32 family protein -
  I6H77_RS00575 (I6H77_00575) - 119735..120415 (-) 681 WP_000209232.1 ABC transporter ATP-binding protein -
  I6H77_RS00580 (I6H77_00580) - 120429..121484 (-) 1056 WP_000280278.1 ABC transporter permease -
  I6H77_RS00585 (I6H77_00585) - 121871..122155 (+) 285 WP_001276162.1 DUF3270 domain-containing protein -
  I6H77_RS00590 (I6H77_00590) ciaH 122220..123557 (-) 1338 WP_000482347.1 sensor histidine kinase Regulator
  I6H77_RS00595 (I6H77_00595) ciaR 123547..124221 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  I6H77_RS00600 (I6H77_00600) - 124331..126877 (-) 2547 WP_001149145.1 M1 family metallopeptidase -
  I6H77_RS00605 (I6H77_00605) - 126999..127439 (-) 441 WP_000188823.1 ASCH domain-containing protein -
  I6H77_RS00610 (I6H77_00610) - 127436..128284 (-) 849 WP_001245872.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50847.53 Da        Isoelectric Point: 9.5838

>NTDB_id=516430 I6H77_RS00590 WP_000482347.1 122220..123557(-) (ciaH) [Streptococcus oralis strain FDAARGOS_1020]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSSSPQAVIQLALNRATEEVKDIQPAT
ADANKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMILMETNSSSVSSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
NLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPEIAEVSPQFFKTTFANYELIASENDRIFEYENRI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVHATDRHLYLTVTDNGIGISATDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKIAIQSPSKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=516430 I6H77_RS00590 WP_000482347.1 122220..123557(-) (ciaH) [Streptococcus oralis strain FDAARGOS_1020]
ATGTTCAATAAACTAAAAAAAACATGGTATGCGGATGATTTCAGCTATTTCATTCGAAACTTTGGAGTGTTCACCCTGAT
CTTCTCTGCTATGACCTTGATTATCCTCCAGGTCATGCACTCGAGTCTCTACACTTCTGTAGATGAAAAACTCCAAGCCC
TTAGTAGCAGTCCCCAAGCGGTTATCCAGTTGGCCCTGAATCGGGCAACTGAAGAGGTCAAGGATATTCAACCAGCAACA
GCGGATGCCAACAAGGCTGAAATCAAACCCAATGTCAGCTCCAATACGGAAGTCTTGCTCTTTGACAAGGATTTTAACCA
ACTCTTACTGGGCAATCGTTTTTTAGGTTTGGATAAGATCAAGCTGGACAAAAAAGAGTTGAATCACATTCGGCAAATCC
AAGTTGTCAATAGTTACGGTCAGGAAGAAACCTATCGGATGATTTTGATGGAAACCAACTCTTCCTCCGTATCAAGTAAC
GTCAAGTATGCGGCGGTTTTAATCAATACTAGCCAGCTCGAGCAAATCAGCCAAAACCACGAGCATTTAATTGTTGTAGT
CATGGCTAGTTTCTGGCTCCTGTCTTTAATTGCCAGTGTTTATTTGGCACGTGTCAGTGTCAAACCCTTGCTGGAAAGTA
TGCAAAAGCAGAAGTCCTTTGTTGAAAATGCTAGTCACGAACTGAGAACGCCTTTGGCCGTTTTACAAAATCGGTTAGAG
AATCTCTTTCGAAAACCAGAGGCAACGATTATGGAATCCAGCGAAAGTATCGCTTCCAGTCTTGAAGAAGTTCGCAACAT
GCGTTTCCTCACGACCAATCTTCTCAACCTTGCACGTCGCGATGATGGAATCAAACCAGAAATAGCAGAAGTATCACCAC
AGTTCTTTAAGACAACCTTTGCTAACTATGAGTTGATTGCTTCTGAAAATGATCGTATTTTTGAGTATGAAAATCGGATT
TATCGTCCTTTCATGACCGATCAGTTGCTCCTAAAACAACTCATGACCATCTTATTTGACAATGCCATCAAGTATACTGA
AGAAGATGGGAAAATTGAGTTTGTAGTCCATGCTACAGATCGTCACCTTTATCTAACAGTAACGGATAATGGAATTGGAA
TCTCAGCTACTGATAAGAAGAAAATCTTTGATCGATTTTACCGTGTAGACAAGGCGAGAACCCGTCAGAAAGGTGGCTTT
GGTCTTGGACTATCTTTGGCCAAGCAGATTGTTGATGCTTTGCGAGGAACGATTAGCGTGAAAGATAACAAACCTAGAGG
AACGATTTTTGAAGTTAAAATCGCTATTCAATCTCCTTCAAAACGTAAGAATAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7H9FD82

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae D39

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae R6

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae TIGR4

83.973

99.551

0.836
  ciaH Streptococcus mutans UA159

54.795

98.427

0.539