Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   I6G42_RS00105 Genome accession   NZ_CP065707
Coordinates   11827..13980 (+) Length   717 a.a.
NCBI ID   WP_038804513.1    Uniprot ID   A0A7T2ZWS4
Organism   Streptococcus oralis strain FDAARGOS_885     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 6827..18980
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6G42_RS00055 (I6G42_00055) blpZ 7128..7376 (-) 249 WP_000276518.1 immunity protein BlpZ -
  I6G42_RS00060 (I6G42_00060) - 7456..7674 (-) 219 WP_000438252.1 hypothetical protein -
  I6G42_RS00065 (I6G42_00065) - 7680..8054 (-) 375 WP_038804503.1 hypothetical protein -
  I6G42_RS00070 (I6G42_00070) - 8088..8282 (-) 195 WP_038804504.1 Blp family class II bacteriocin -
  I6G42_RS00075 (I6G42_00075) - 8510..8914 (-) 405 WP_038804506.1 hypothetical protein -
  I6G42_RS00080 (I6G42_00080) - 8943..9263 (-) 321 WP_000645118.1 hypothetical protein -
  I6G42_RS00085 (I6G42_00085) - 9278..9505 (-) 228 WP_038804508.1 bacteriocin class II family protein -
  I6G42_RS00090 (I6G42_00090) - 9693..10097 (-) 405 WP_038804509.1 hypothetical protein -
  I6G42_RS00095 (I6G42_00095) - 10825..11028 (-) 204 WP_038804511.1 hypothetical protein -
  I6G42_RS00100 (I6G42_00100) - 11342..11545 (-) 204 WP_038804512.1 Blp family class II bacteriocin -
  I6G42_RS00105 (I6G42_00105) comA/nlmT 11827..13980 (+) 2154 WP_038804513.1 peptide cleavage/export ABC transporter BlpA Regulator
  I6G42_RS00110 (I6G42_00110) - 13991..15352 (+) 1362 WP_038804515.1 bacteriocin secretion accessory protein -
  I6G42_RS00115 (I6G42_00115) blpC 15409..15564 (+) 156 WP_038804516.1 quorum-sensing system pheromone BlpC -
  I6G42_RS00120 (I6G42_00120) - 15607..16947 (-) 1341 WP_038804518.1 sensor histidine kinase -
  I6G42_RS00125 (I6G42_00125) comE/blpR 16961..17698 (-) 738 WP_038804519.1 response regulator transcription factor Regulator
  I6G42_RS00130 (I6G42_00130) - 17703..18041 (-) 339 WP_038804520.1 LytTR family DNA-binding domain-containing protein -
  I6G42_RS00135 (I6G42_00135) - 18320..18649 (+) 330 WP_038804521.1 hypothetical protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80824.87 Da        Isoelectric Point: 7.9419

>NTDB_id=513248 I6G42_RS00105 WP_038804513.1 11827..13980(+) (comA/nlmT) [Streptococcus oralis strain FDAARGOS_885]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAANEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTRKDYLIIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISIGLIITYILQQAMSFSRDYLLTVLSQRLSID
VILAYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLLLDVSILILVGSVLLAQNPNLFLLSLISVPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLTKYSILQTNLKQGTKL
VLNIFILWFGAQLVMSSKISIGQLITFNTLLSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSNFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKEGDKVSLVGVSGSGKTTLAKMIVNFFDPYKGQITINRQDIKNIDKKILRRHI
NYLPQQAYIFNGSILENLTLGGNNMISQEDILKACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSALDVLTEKKVIDNLMSLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELIQAQGFYHHLFNK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=513248 I6G42_RS00105 WP_038804513.1 11827..13980(+) (comA/nlmT) [Streptococcus oralis strain FDAARGOS_885]
ATGACTTCTTATAAACGTACATTTGTTCCCCAAATAGATGCTAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCCAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCAAATGAAATGGGCTTTGAAACAAGGCCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGGAAACTCCAACATTACTATGTTGTCTATCAAACAAGGAAAGACTA
TCTGATTATTGGTGATCCTGATCCTTCTGTAAAAATCACCAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTGAGCTTCCTCCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTAGTCACTATTATCAATATCGGTGGTTCTTA
TTATCTCCAAGGAATCTTGGATGAGTACATTCCAAATCAGATGAAATCAACTTTAGGAATTATCTCAATTGGTCTAATTA
TCACCTATATCCTCCAACAAGCCATGAGCTTCTCCAGAGATTATCTCCTAACTGTTCTGAGTCAGAGATTAAGCATTGAT
GTAATTTTGGCCTATATTCGTCATATCTTTGAACTTCCTATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCATTTC
ACGCTTCACAGATGCCAACTCTATTATAGATGCCTTAGCTTCTACCATTCTCTCTCTTCTTCTTGATGTTTCCATTCTGA
TCCTTGTAGGGAGCGTCTTACTGGCACAAAACCCTAATCTCTTCCTTCTTTCTCTTATTTCCGTTCCTATATACATGTTC
ATCATCTTTTCTTTTATGAAACCTTTTGAAAAAATGAACCACGATGTCATGCAAAGCAATTCTATGGTTAGTTCTGCCAT
TATCGAAGATATCAACGGGATCGAAACCATCAAGTCACTCACAAGTGAAGAAAATCGCTACCAAAATATTGACAGTGAAT
TTGTCGATTATTTGGAAAAATCCTTTAAACTTACTAAATATTCTATTTTACAAACTAATTTAAAGCAAGGAACAAAGTTA
GTTCTTAATATCTTTATCCTATGGTTTGGTGCTCAATTAGTCATGTCGAGTAAGATTTCTATCGGTCAGCTGATTACCTT
TAATACACTTCTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTACAAACTAAACTCCAATCTGCGAAGGTTG
CTAATAACCGCTTGAACGAGGTCTATTTAGTTGAATCTGAATTTCAAGTTCAAGAAAATCCTGTTCATTCAAATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATCAATCTAACAAT
TAAAGAAGGTGATAAGGTTAGCCTGGTTGGAGTTAGTGGTTCTGGTAAAACAACTCTAGCCAAAATGATTGTCAATTTCT
TTGACCCTTACAAAGGACAGATTACCATCAATCGTCAGGATATTAAAAATATTGATAAAAAAATCTTGCGACGTCATATT
AATTACCTGCCCCAACAAGCCTATATCTTTAATGGCTCTATCTTGGAAAACTTAACCTTGGGCGGTAATAATATGATTAG
CCAAGAAGATATTCTAAAAGCTTGCGAATTAGCTGAAATCCGTCAAGATATTGAAAGAATGCCTATGGGCTATCAAACTC
AACTTTCTGATGGAGCAGGTCTGTCAGGAGGACAGAAGCAACGAATTGCTCTCGCTCGTGCTCTTTTAACTAAATCTCCT
GTTTTAATACTAGATGAAGCTACTAGTGCTCTCGATGTTTTGACTGAGAAAAAGGTTATAGATAATCTTATGTCCCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTAAGTATAGCCGAACGGACTAACCGTGTCATTGTTCTTGACCAGGGTA
AAATCATTGAAGTTGGTAGTCATCAAGAGTTAATACAGGCGCAAGGCTTCTACCATCATCTATTCAACAAATAA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(169-438)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-649)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7T2ZWS4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

71.329

99.721

0.711
  comA Streptococcus mitis NCTC 12261

65.919

99.442

0.656
  comA Streptococcus pneumoniae D39

65.358

99.442

0.65
  comA Streptococcus mitis SK321

65.358

99.442

0.65
  comA Streptococcus pneumoniae R6

65.358

99.442

0.65
  comA Streptococcus pneumoniae Rx1

65.358

99.442

0.65
  comA Streptococcus gordonii str. Challis substr. CH1

64.714

100

0.647
  comA Streptococcus pneumoniae TIGR4

65.077

99.442

0.647