Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   I6G43_RS04500 Genome accession   NZ_CP065706
Coordinates   947555..948229 (+) Length   224 a.a.
NCBI ID   WP_000590635.1    Uniprot ID   A0A139R176
Organism   Streptococcus oralis strain FDAARGOS_886     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 942555..953229
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6G43_RS04480 (I6G43_04480) - 942721..943449 (+) 729 WP_038806194.1 GNAT family N-acetyltransferase -
  I6G43_RS04485 (I6G43_04485) - 943491..944339 (+) 849 WP_038806193.1 putative PEP-binding protein -
  I6G43_RS04490 (I6G43_04490) - 944336..944776 (+) 441 WP_038806192.1 ASCH domain-containing protein -
  I6G43_RS04495 (I6G43_04495) - 944897..947443 (+) 2547 WP_038806191.1 M1 family metallopeptidase -
  I6G43_RS04500 (I6G43_04500) ciaR 947555..948229 (+) 675 WP_000590635.1 two-component system response regulator CiaR Regulator
  I6G43_RS04505 (I6G43_04505) ciaH 948219..949556 (+) 1338 WP_009014020.1 sensor histidine kinase Regulator
  I6G43_RS04510 (I6G43_04510) - 949624..949908 (-) 285 WP_001111510.1 DUF3270 domain-containing protein -
  I6G43_RS04515 (I6G43_04515) - 950293..951348 (+) 1056 WP_000280273.1 ABC transporter permease -
  I6G43_RS04520 (I6G43_04520) - 951362..952042 (+) 681 WP_000125742.1 ABC transporter ATP-binding protein -
  I6G43_RS04525 (I6G43_04525) - 952170..953099 (+) 930 WP_038806190.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25465.26 Da        Isoelectric Point: 4.2660

>NTDB_id=513219 I6G43_RS04500 WP_000590635.1 947555..948229(+) (ciaR) [Streptococcus oralis strain FDAARGOS_886]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDVVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=513219 I6G43_RS04500 WP_000590635.1 947555..948229(+) (ciaR) [Streptococcus oralis strain FDAARGOS_886]
ATGATAAAAATCTTATTAGTAGAAGATGACCTAGGTCTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCAGATGT
CATGCAGGTCTTTGATGGAGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTTTATGACTTGATTCTGCTTGACCTCATGT
TGCCTGAAAAAAATGGTTTCCAAGTTTTGAAAGAATTACGTGAAAAAGGAATTACAACCCCTGTCCTTATCATGACTGCT
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAGTTGGGAGCGGATGACTATCTAACAAAACCTTTCTATCTAGAAGA
ACTCAAAATGCGGATTCAAGCCCTGCTCAAACGTTCAGGCAAGTTTAACGAAAATACCTTGACCTATGGGGATGTTGTCG
TCAACCTTTCAACGAATGAAGTAAAAGTGGAAGATACTCCTGTGGAACTGCTCGGGAAAGAGTTTGAGTTATTGGTTTAC
TTCCTTCAAAATCAAAATGTTATTCTTCCCAAGACACAAATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACTAT
TTCCGTTGTAGAAGTATATGTCTCAAAAGTTCGTAAGAAATTGAAGGGGACAGCCTTTGCTGAAAACCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A139R176

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

97.321

100

0.973
  ciaR Streptococcus pneumoniae D39

97.321

100

0.973
  ciaR Streptococcus pneumoniae R6

97.321

100

0.973
  ciaR Streptococcus pneumoniae Rx1

97.321

100

0.973
  ciaR Streptococcus mutans UA159

87.5

100

0.875
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366