Detailed information NTG0051153

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SPAF_RS10320
• Genome accession: NC_017905
• Coordinates: 2169551..2170732 (+)
• Length: 393 a.a.
• NCBI ID: WP_013904367.1
• Uniprot ID: I1ZPR6
• Organism: Streptococcus parasanguinis FW213
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2164551..2175732

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPAF_RS10300 (Spaf_2105)	comE/comE2	2166309..2167067 (-)	759	WP_003018434.1	response regulator transcription factor	Regulator
SPAF_RS10305 (Spaf_2106)	-	2167064..2168404 (-)	1341	WP_041826511.1	GHKL domain-containing protein	-
SPAF_RS10315 (Spaf_2107)	rlmH	2168867..2169346 (-)	480	WP_014714108.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SPAF_RS10320 (Spaf_2108)	htrA	2169551..2170732 (+)	1182	WP_013904367.1	S1C family serine protease	Regulator
SPAF_RS10325 (Spaf_2109)	-	2170804..2171564 (+)	761	Protein_1990	ParB/RepB/Spo0J family partition protein	-

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41690.83 Da
• Isoelectric Point: 6.1559

>NTDB_id=51153 SPAF_RS10320 WP_013904367.1 2169551..2170732(+) (htrA) [Streptococcus parasanguinis FW213]
MKSSSNLLKKVGNIALIFVVGFLGGILGTFLTLKTSHSSTSNTESKQVHSTTVKTAYKNTTSTSEAVDKVKNAVVSVITY
SDSSNQGVFEKEENPDSQISSEGSGVIYKKEGKYAYLVTNTHVINGAKKVDILLADGNKVSGEVVGSDVYSDIAVVRISA
DKAKAVAEFGDSNQLTVGETAIAIGSPLGTDYANSVTQGIISSQGRNVKLKADNGQNISTRALQTDAAINPGNSGGPLIN
IQGQVIGITSSKISNNGQTSVEGMGFAIPANDVVNIIKQLEEKGKVVRPALGIQMMDLSNLSTSDLSQLKLPEKISGGVL
VRSTLENMPASDKLQRYDVITKIDDTDIESTADLQSALYSHQINDTIKVTFYRDGKQQTTSIKLTKSTEDLSE

Nucleotide

• Length: 1182 bp

>NTDB_id=51153 SPAF_RS10320 WP_013904367.1 2169551..2170732(+) (htrA) [Streptococcus parasanguinis FW213]
ATGAAATCTTCATCTAATTTACTGAAAAAAGTTGGGAACATAGCCCTCATTTTTGTTGTAGGTTTTCTAGGTGGGATTCT
TGGAACCTTTTTAACCTTAAAAACATCTCATTCTTCTACTTCAAATACTGAAAGTAAGCAAGTCCACTCAACCACTGTTA
AAACAGCTTATAAAAACACAACCTCAACTAGTGAGGCCGTCGATAAGGTGAAAAATGCTGTAGTTTCTGTGATTACTTAT
TCTGATTCTTCGAATCAAGGAGTGTTTGAAAAAGAAGAAAACCCTGACTCACAAATTTCTAGTGAAGGTTCTGGGGTCAT
TTATAAAAAAGAAGGAAAATATGCCTACCTTGTTACCAATACCCATGTGATTAATGGTGCTAAAAAAGTAGATATTCTTT
TAGCAGATGGTAATAAAGTCTCTGGAGAAGTAGTTGGGTCAGATGTCTATTCTGATATTGCAGTAGTTCGAATTAGTGCG
GATAAAGCAAAGGCAGTAGCTGAATTCGGAGATTCAAACCAATTAACGGTCGGTGAGACTGCAATTGCAATTGGTAGCCC
TCTTGGAACAGATTATGCTAATTCTGTTACCCAAGGGATTATTTCCAGCCAAGGTCGCAATGTGAAATTGAAAGCCGATA
ATGGACAAAATATCTCTACACGCGCTCTACAAACAGACGCAGCCATCAACCCAGGAAACTCTGGAGGTCCATTAATCAAT
ATTCAAGGACAAGTCATCGGGATTACCTCAAGTAAAATTTCAAATAACGGACAAACTTCAGTAGAAGGAATGGGATTTGC
AATTCCTGCAAATGATGTTGTCAATATTATCAAGCAACTAGAAGAAAAAGGAAAAGTAGTTCGACCAGCTCTTGGAATCC
AAATGATGGATTTATCCAACCTTTCAACTTCTGATTTAAGCCAATTAAAACTACCTGAAAAAATCTCTGGAGGAGTACTG
GTTCGTTCAACACTTGAAAATATGCCTGCTTCAGATAAATTGCAACGCTACGATGTGATCACAAAGATCGACGATACAGA
TATCGAGTCAACTGCAGATTTACAATCTGCCCTCTATTCTCACCAAATCAATGATACGATCAAGGTCACATTCTATCGTG
ATGGAAAACAACAAACAACTTCTATCAAGTTAACAAAATCAACTGAGGATCTTAGTGAGTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (289-384)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

3D structure

• AlphaFold DB: I1ZPR6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	67.839	100	0.687
htrA	Streptococcus mitis NCTC 12261	62.972	100	0.636
htrA	Streptococcus pneumoniae Rx1	63.104	100	0.631
htrA	Streptococcus pneumoniae D39	63.104	100	0.631
htrA	Streptococcus pneumoniae R6	63.104	100	0.631
htrA	Streptococcus pneumoniae TIGR4	63.104	100	0.631
htrA	Streptococcus mutans UA159	53.747	98.473	0.529