Detailed information NTG0511378

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: STCNRZ1202_RS04625
• Genome accession: NZ_CP065506
• Coordinates: 870048..870773 (+)
• Length: 241 a.a.
• NCBI ID: WP_179972946.1
• Uniprot ID: A0A7U7H0X6
• Organism: Streptococcus thermophilus strain CNRZ1202
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 865048..875773

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STCNRZ1202_RS04590 (STCNRZ1202_04600)	-	865153..865335 (+)	183	WP_006531883.1	Blp family class II bacteriocin	-
STCNRZ1202_RS04595 (STCNRZ1202_04605)	-	865952..866182 (+)	231	WP_043878356.1	bacteriocin	-
STCNRZ1202_RS04600 (STCNRZ1202_04610)	-	866271..866582 (+)	312	WP_003066586.1	hypothetical protein	-
STCNRZ1202_RS04605 (STCNRZ1202_04615)	-	866796..866888 (+)	93	Protein_849	Blp family class II bacteriocin	-
STCNRZ1202_RS04610 (STCNRZ1202_04620)	-	866946..867350 (+)	405	WP_015695682.1	hypothetical protein	-
STCNRZ1202_RS04615 (STCNRZ1202_04625)	-	867531..868577 (+)	1047	WP_095559358.1	thioredoxin fold domain-containing protein	-
STCNRZ1202_RS04620 (STCNRZ1202_04630)	-	869109..869873 (+)	765	WP_232086163.1	DUF6261 family protein	-
STCNRZ1202_RS04625 (STCNRZ1202_04635)	comE/comE1	870048..870773 (+)	726	WP_179972946.1	response regulator transcription factor	Regulator
STCNRZ1202_RS04630 (STCNRZ1202_04640)	-	870786..872105 (+)	1320	WP_095559360.1	GHKL domain-containing protein	-
STCNRZ1202_RS04635 (STCNRZ1202_04645)	-	872126..872275 (-)	150	WP_006531893.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
STCNRZ1202_RS04645 (STCNRZ1202_04655)	-	872802..873386 (+)	585	WP_232086162.1	hypothetical protein	-
STCNRZ1202_RS04650 (STCNRZ1202_04660)	csm6	873401..874687 (+)	1287	WP_347229791.1	type III-A CRISPR-associated CARF protein Csm6	-
STCNRZ1202_RS04655 (STCNRZ1202_04665)	pyrF	874887..875582 (+)	696	WP_347229792.1	orotidine-5'-phosphate decarboxylase	-

Sequence

Protein

• Length: 241 a.a.
• Molecular weight: 28020.99 Da
• Isoelectric Point: 5.2156

>NTDB_id=511378 STCNRZ1202_RS04625 WP_179972946.1 870048..870773(+) (comE/comE1) [Streptococcus thermophilus strain CNRZ1202]
MDIFVLEDDIPQQFRMERAINLVMESNNWHYRYLEISSNPDEIIAVAGNGEHQIFFLDLEIKGEEQQGIDVAKAIREKNS
TAIIVFVTTHSEFMLLTYQSLVGAIDFIDKGLNEEAFNERLFVCLKEAVKRQEGNFGEHSYLFHTPQAKVRVAYDDILFF
ETSPAPHRIILHTKNERTEFYATIAEVAKSDERLFRCHRSFVVNVDNIARFDMRYKLIYFEMGETCPVARAKVKLLQEKI
G

Nucleotide

• Length: 726 bp

>NTDB_id=511378 STCNRZ1202_RS04625 WP_179972946.1 870048..870773(+) (comE/comE1) [Streptococcus thermophilus strain CNRZ1202]
GTGGATATTTTTGTACTCGAAGATGATATTCCCCAACAATTCCGAATGGAGCGTGCTATTAATCTTGTGATGGAATCAAA
TAACTGGCATTATCGGTATTTGGAGATTTCATCTAATCCTGATGAAATCATCGCAGTAGCAGGTAATGGTGAACATCAAA
TTTTCTTTCTTGATTTAGAAATTAAAGGTGAAGAGCAGCAAGGGATTGATGTTGCTAAAGCTATTCGTGAAAAAAATAGC
ACAGCTATTATTGTTTTTGTGACGACACATTCTGAATTCATGCTCTTAACCTATCAATCTTTAGTAGGTGCTATTGACTT
TATTGACAAAGGATTAAACGAAGAAGCGTTTAATGAACGCTTATTCGTTTGTCTTAAAGAAGCTGTCAAACGCCAAGAGG
GAAACTTTGGTGAACATTCCTACTTGTTTCATACCCCACAAGCCAAAGTGCGGGTAGCTTATGATGATATTTTATTTTTT
GAAACGTCACCAGCACCTCATCGTATTATTTTGCACACTAAGAACGAACGTACAGAATTTTATGCGACCATAGCAGAAGT
GGCAAAATCAGATGAACGTCTTTTTAGATGTCATCGTTCTTTTGTGGTTAACGTGGATAATATCGCTAGATTTGATATGA
GGTATAAGCTCATTTATTTTGAGATGGGAGAAACCTGTCCTGTAGCTAGGGCTAAGGTGAAATTATTACAGGAGAAAATT
GGATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-120)

• LytTr DNA-binding domain (LytTR) (150-240)

3D structure

• AlphaFold DB: A0A7U7H0X6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	65.823	98.34	0.647
comE/blpR	Streptococcus mutans UA159	46.091	100	0.465
comE/comE2	Streptococcus equinus JB1	44.167	99.585	0.44
comE/comE2	Streptococcus gordonii strain NCTC7865	35.06	100	0.365
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	35.06	100	0.365
agrA	Staphylococcus aureus N315	35.656	100	0.361