Detailed information NTG0511135

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: STAVA116_RS04225
• Genome accession: NZ_CP065498
• Coordinates: 809286..810125 (+)
• Length: 279 a.a.
• NCBI ID: WP_011225887.1
• Uniprot ID: Q5M4N4
• Organism: Streptococcus thermophilus strain AVA116
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 804286..815125

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STAVA116_RS04195 (STAVA116_04165)	-	804702..805229 (+)	528	WP_087009879.1	ECF transporter S component	-
STAVA116_RS04200 (STAVA116_04170)	-	805253..805768 (+)	516	WP_087009880.1	transcription repressor NadR	-
STAVA116_RS04205 (STAVA116_04175)	-	805863..806552 (+)	690	WP_011225885.1	helix-turn-helix transcriptional regulator	-
STAVA116_RS04210 (STAVA116_04180)	ylqF	806680..807534 (+)	855	WP_087009881.1	ribosome biogenesis GTPase YlqF	-
STAVA116_RS04215 (STAVA116_04185)	-	807521..808288 (+)	768	WP_002950603.1	ribonuclease HII	-
STAVA116_RS04220 (STAVA116_04190)	-	808299..809219 (+)	921	WP_002950604.1	ROK family protein	-
STAVA116_RS04225 (STAVA116_04195)	dprA	809286..810125 (+)	840	WP_011225887.1	DNA-processing protein DprA	Machinery gene
STAVA116_RS04230 (STAVA116_04200)	topA	810293..812437 (+)	2145	WP_087009882.1	type I DNA topoisomerase	-
STAVA116_RS04235 (STAVA116_04205)	-	812555..813379 (+)	825	WP_087009883.1	TraX family protein	-
STAVA116_RS04240 (STAVA116_04210)	-	813415..814074 (+)	660	WP_087009884.1	response regulator transcription factor	-

Sequence

Protein

• Length: 279 a.a.
• Molecular weight: 31247.18 Da
• Isoelectric Point: 8.6571

>NTDB_id=511135 STAVA116_RS04225 WP_011225887.1 809286..810125(+) (dprA) [Streptococcus thermophilus strain AVA116]
MNNFELFKLKAAGLTNLNILNILDYQKNQDKKLSLRDMAVVSKSKNAVLFMEKYKNLDVKQLKEDFQRFPTLSIFDKEYP
IELKHSYNPPVLLFYQGNIDLLSKPKLAVVGARKCSETGKQSVRKIVHELGNAFTIVSGLARGIDTCAHMEALKNKGNTI
AVIGTGLDVYYPKENKALQDYMAKNHLVLTEYGPGEQPLKYHYPERNRIISGLCQGVMVVEAKLRSGSLITCERAMEEGR
DVFAIPGNILDGKSDGCHHLIQEGAKCITTGFDIISEFS

Nucleotide

• Length: 840 bp

>NTDB_id=511135 STAVA116_RS04225 WP_011225887.1 809286..810125(+) (dprA) [Streptococcus thermophilus strain AVA116]
ATGAATAACTTTGAACTTTTTAAACTAAAAGCTGCTGGATTGACGAATTTAAACATCCTTAACATTTTAGACTATCAAAA
AAATCAAGATAAAAAATTGAGCTTACGTGATATGGCAGTGGTATCTAAGTCTAAAAATGCCGTTCTCTTTATGGAAAAAT
ACAAGAATTTAGATGTTAAGCAGCTTAAGGAAGATTTTCAACGTTTTCCGACCTTATCAATTTTTGATAAGGAGTATCCC
ATTGAGCTGAAACATTCCTATAATCCTCCTGTCCTCCTCTTTTATCAAGGGAATATTGATTTGCTAAGTAAACCCAAGTT
AGCGGTAGTTGGTGCCAGAAAGTGTTCTGAAACAGGCAAACAGTCTGTTCGAAAAATTGTTCATGAACTTGGGAATGCCT
TTACTATTGTAAGTGGCTTGGCGCGTGGAATTGATACTTGTGCTCATATGGAGGCCTTAAAAAATAAAGGTAACACCATT
GCAGTTATCGGGACTGGGCTAGACGTATATTATCCTAAAGAAAACAAAGCTTTACAGGACTATATGGCTAAAAATCATTT
AGTTCTTACAGAATACGGACCGGGTGAACAGCCACTTAAATACCATTATCCTGAACGAAATCGGATAATTTCTGGATTGT
GTCAAGGGGTTATGGTGGTTGAAGCCAAGCTTCGCTCGGGAAGTCTTATTACTTGTGAGCGTGCAATGGAAGAAGGAAGA
GATGTTTTCGCCATACCAGGAAATATTTTAGATGGAAAATCGGATGGATGCCATCACCTCATTCAAGAGGGCGCAAAGTG
CATTACTACAGGATTTGACATCATTTCAGAATTTTCATAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (71-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: Q5M4N4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	72.043	100	0.72
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae D39	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae R6	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	62.95	99.642	0.627
dprA/cilB/dalA	Streptococcus mitis SK321	62.95	99.642	0.627
dprA	Lactococcus lactis subsp. cremoris KW2	60.432	99.642	0.602
dprA	Latilactobacillus sakei subsp. sakei 23K	39.768	92.832	0.369
dprA	Bacillus subtilis subsp. subtilis str. 168	48.095	75.269	0.362