Detailed information NTG0511063

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ST4067_RS01480
• Genome accession: NZ_CP065496
• Coordinates: 267748..268647 (+)
• Length: 299 a.a.
• NCBI ID: WP_011225448.1
• Uniprot ID: Q5M612
• Organism: Streptococcus thermophilus strain 4067
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 262748..273647

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST4067_RS01460 (ST4067_01455)	trkA	263885..265234 (-)	1350	WP_011225444.1	Trk system potassium transporter TrkA	-
ST4067_RS01465 (ST4067_01460)	-	265492..266031 (+)	540	WP_372585740.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
ST4067_RS01470 (ST4067_01465)	-	266343..266900 (+)	558	WP_263604586.1	ECF transporter S component	-
ST4067_RS01475 (ST4067_01470)	-	266903..267553 (+)	651	WP_084830987.1	phosphatase PAP2 family protein	-
ST4067_RS01480 (ST4067_01475)	comR	267748..268647 (+)	900	WP_011225448.1	helix-turn-helix domain-containing protein	Regulator
ST4067_RS01485 (ST4067_01480)	-	268885..270063 (+)	1179	Protein_237	ABC transporter transmembrane domain-containing protein	-
ST4067_RS01490 (ST4067_01495)	-	270349..270917 (+)	569	Protein_238	ATP-binding cassette domain-containing protein	-
ST4067_RS01495 (ST4067_01500)	-	271025..271336 (+)	312	WP_011226857.1	DUF805 domain-containing protein	-
ST4067_RS01505	-	271828..272130 (-)	303	WP_263604587.1	hypothetical protein	-
ST4067_RS01510	-	272362..272733 (-)	372	WP_263604588.1	hypothetical protein	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35303.77 Da
• Isoelectric Point: 5.1073

>NTDB_id=511063 ST4067_RS01480 WP_011225448.1 267748..268647(+) (comR) [Streptococcus thermophilus strain 4067]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=511063 ST4067_RS01480 WP_011225448.1 267748..268647(+) (comR) [Streptococcus thermophilus strain 4067]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAAATCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (75-292)

• Helix-turn-helix (HTH_3) (11-66)

3D structure

• AlphaFold DB: Q5M612

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	100	100	1
comR	Streptococcus thermophilus LMD-9	99.331	100	0.993
comR	Streptococcus salivarius strain HSISS4	95.318	100	0.953
comR	Streptococcus salivarius SK126	94.649	100	0.946
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421