Detailed information NTG0510823

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: STCNRZ887_RS01470
• Genome accession: NZ_CP065491
• Coordinates: 269903..270802 (+)
• Length: 299 a.a.
• NCBI ID: WP_011225448.1
• Uniprot ID: Q5M612
• Organism: Streptococcus thermophilus strain CNRZ887
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 264903..275802

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STCNRZ887_RS01450 (STCNRZ887_01460)	trkA	266029..267378 (-)	1350	WP_011225444.1	Trk system potassium transporter TrkA	-
STCNRZ887_RS01455 (STCNRZ887_01465)	-	267666..268175 (+)	510	WP_011680717.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
STCNRZ887_RS01460 (STCNRZ887_01470)	-	268487..269044 (+)	558	WP_002949523.1	ECF transporter S component	-
STCNRZ887_RS01465 (STCNRZ887_01475)	-	269047..269697 (+)	651	WP_011225447.1	phosphatase PAP2 family protein	-
STCNRZ887_RS01470 (STCNRZ887_01480)	comR	269903..270802 (+)	900	WP_011225448.1	helix-turn-helix domain-containing protein	Regulator
STCNRZ887_RS01475 (STCNRZ887_01485)	-	271040..272218 (+)	1179	Protein_237	ABC transporter transmembrane domain-containing protein	-
STCNRZ887_RS01480 (STCNRZ887_01500)	-	272504..273072 (+)	569	Protein_238	ATP-binding cassette domain-containing protein	-
STCNRZ887_RS01485 (STCNRZ887_01505)	-	273180..273497 (+)	318	WP_011225454.1	DUF805 domain-containing protein	-
STCNRZ887_RS01490	-	273984..274784 (-)	801	WP_011225455.1	hypothetical protein	-
STCNRZ887_RS01495 (STCNRZ887_01515)	-	275285..275800 (+)	516	WP_002949547.1	AmiS/UreI family transporter	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35303.77 Da
• Isoelectric Point: 5.1073

>NTDB_id=510823 STCNRZ887_RS01470 WP_011225448.1 269903..270802(+) (comR) [Streptococcus thermophilus strain CNRZ887]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=510823 STCNRZ887_RS01470 WP_011225448.1 269903..270802(+) (comR) [Streptococcus thermophilus strain CNRZ887]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAAATCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTAGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (75-292)

• Helix-turn-helix (HTH_3) (11-66)

3D structure

• AlphaFold DB: Q5M612

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	100	100	1
comR	Streptococcus thermophilus LMD-9	99.331	100	0.993
comR	Streptococcus salivarius strain HSISS4	95.318	100	0.953
comR	Streptococcus salivarius SK126	94.649	100	0.946
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421