Detailed information NTG0510664

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: STAVA1121_RS04750
• Genome accession: NZ_CP065488
• Coordinates: 882012..882737 (+)
• Length: 241 a.a.
• NCBI ID: WP_179972946.1
• Uniprot ID: A0A7U7H0X6
• Organism: Streptococcus thermophilus strain AVA1121
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 877012..887737

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STAVA1121_RS04715 (STAVA1121_04645)	-	877106..877288 (+)	183	WP_006531883.1	Blp family class II bacteriocin	-
STAVA1121_RS04720 (STAVA1121_04650)	-	877905..878135 (+)	231	WP_043878356.1	bacteriocin	-
STAVA1121_RS04725 (STAVA1121_04655)	-	878224..878535 (+)	312	WP_347131537.1	hypothetical protein	-
STAVA1121_RS04730 (STAVA1121_04660)	-	878748..878840 (+)	93	Protein_874	Blp family class II bacteriocin	-
STAVA1121_RS04735 (STAVA1121_04665)	-	878898..879302 (+)	405	WP_015695682.1	hypothetical protein	-
STAVA1121_RS04740 (STAVA1121_04670)	-	879483..880529 (+)	1047	WP_095559358.1	thioredoxin fold domain-containing protein	-
STAVA1121_RS04745 (STAVA1121_04675)	-	881061..881825 (+)	765	WP_232086163.1	DUF6261 family protein	-
STAVA1121_RS04750 (STAVA1121_04680)	comE/comE1	882012..882737 (+)	726	WP_179972946.1	response regulator transcription factor	Regulator
STAVA1121_RS04755 (STAVA1121_04685)	-	882750..884069 (+)	1320	WP_095559360.1	GHKL domain-containing protein	-
STAVA1121_RS04760 (STAVA1121_04690)	-	884090..884239 (-)	150	WP_006531893.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
STAVA1121_RS04770 (STAVA1121_04700)	-	884766..885350 (+)	585	WP_232086162.1	hypothetical protein	-
STAVA1121_RS04775 (STAVA1121_04705)	csm6	885365..886651 (+)	1287	WP_347131539.1	type III-A CRISPR-associated CARF protein Csm6	-
STAVA1121_RS04780 (STAVA1121_04710)	pyrF	886851..887546 (+)	696	WP_180478507.1	orotidine-5'-phosphate decarboxylase	-

Sequence

Protein

• Length: 241 a.a.
• Molecular weight: 28020.99 Da
• Isoelectric Point: 5.2156

>NTDB_id=510664 STAVA1121_RS04750 WP_179972946.1 882012..882737(+) (comE/comE1) [Streptococcus thermophilus strain AVA1121]
MDIFVLEDDIPQQFRMERAINLVMESNNWHYRYLEISSNPDEIIAVAGNGEHQIFFLDLEIKGEEQQGIDVAKAIREKNS
TAIIVFVTTHSEFMLLTYQSLVGAIDFIDKGLNEEAFNERLFVCLKEAVKRQEGNFGEHSYLFHTPQAKVRVAYDDILFF
ETSPAPHRIILHTKNERTEFYATIAEVAKSDERLFRCHRSFVVNVDNIARFDMRYKLIYFEMGETCPVARAKVKLLQEKI
G

Nucleotide

• Length: 726 bp

>NTDB_id=510664 STAVA1121_RS04750 WP_179972946.1 882012..882737(+) (comE/comE1) [Streptococcus thermophilus strain AVA1121]
GTGGATATTTTTGTACTCGAAGATGATATTCCCCAACAATTCCGAATGGAGCGTGCTATTAATCTTGTGATGGAATCAAA
TAACTGGCATTATCGGTATTTGGAGATTTCATCTAATCCTGATGAAATCATCGCAGTAGCAGGTAATGGTGAACATCAAA
TTTTCTTTCTTGATTTAGAAATTAAAGGTGAAGAGCAGCAAGGGATTGATGTTGCTAAAGCTATTCGTGAAAAAAATAGC
ACAGCTATTATTGTTTTTGTGACGACACATTCTGAATTCATGCTCTTAACCTATCAATCTTTAGTAGGTGCTATTGACTT
TATTGACAAAGGATTAAACGAAGAAGCGTTTAATGAACGCTTATTCGTTTGTCTTAAAGAAGCTGTCAAACGCCAAGAGG
GAAACTTTGGTGAACATTCCTACTTGTTTCATACCCCACAAGCCAAAGTGCGGGTAGCTTATGATGATATTTTATTTTTT
GAAACGTCACCAGCACCTCATCGTATTATTTTGCACACTAAGAACGAACGTACAGAATTTTATGCGACCATAGCAGAAGT
GGCAAAATCAGATGAACGTCTTTTTAGATGTCATCGTTCTTTTGTGGTTAACGTGGATAATATCGCTAGATTTGATATGA
GGTATAAGCTCATTTATTTTGAGATGGGAGAAACCTGTCCTGTAGCTAGGGCTAAGGTGAAATTATTACAGGAGAAAATT
GGATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-120)

• LytTr DNA-binding domain (LytTR) (150-240)

3D structure

• AlphaFold DB: A0A7U7H0X6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	65.823	98.34	0.647
comE/blpR	Streptococcus mutans UA159	46.091	100	0.465
comE/comE2	Streptococcus equinus JB1	44.167	99.585	0.44
comE/comE2	Streptococcus gordonii strain NCTC7865	35.06	100	0.365
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	35.06	100	0.365
agrA	Staphylococcus aureus N315	35.656	100	0.361