Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   STT19_RS03980 Genome accession   NZ_CP065487
Coordinates   754486..755160 (+) Length   224 a.a.
NCBI ID   WP_113870373.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain ST19     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 749486..760160
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STT19_RS03960 (STT19_03955) - 750614..751186 (-) 573 WP_011681047.1 ECF transporter S component -
  STT19_RS03965 (STT19_03960) coaC 751214..751759 (-) 546 WP_014608202.1 phosphopantothenoylcysteine decarboxylase -
  STT19_RS03970 (STT19_03965) - 751752..752435 (-) 684 WP_002948206.1 phosphopantothenate--cysteine ligase -
  STT19_RS03975 (STT19_03970) - 752629..754299 (+) 1671 WP_024704082.1 formate--tetrahydrofolate ligase -
  STT19_RS03980 (STT19_03975) ciaR 754486..755160 (+) 675 WP_113870373.1 response regulator transcription factor Regulator
  STT19_RS03985 - 755150..756569 (+) 1420 Protein_725 HAMP domain-containing sensor histidine kinase -
  STT19_RS03990 (STT19_04000) - 756670..758240 (+) 1571 WP_095559203.1 IS3-like element ISSth1b family transposase -
  STT19_RS03995 (STT19_04005) - 758431..759639 (+) 1209 Protein_727 ISL3 family transposase -
  STT19_RS04000 (STT19_04010) - 759765..760001 (+) 237 Protein_728 ABC transporter permease -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25418.05 Da        Isoelectric Point: 4.2405

>NTDB_id=510600 STT19_RS03980 WP_113870373.1 754486..755160(+) (ciaR) [Streptococcus thermophilus strain ST19]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLKELREQGITTPILIMTA
KESLDDKGHGFELGADDYLTKPFYLKELKMRIEALLKRSGKFDQNTFSFGDVCVNLSTNSTYVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTNVSVVEVYVSKIRKKLKGTDFATNLQTLRSVGYILKNAD

Nucleotide


Download         Length: 675 bp        

>NTDB_id=510600 STT19_RS03980 WP_113870373.1 754486..755160(+) (ciaR) [Streptococcus thermophilus strain ST19]
ATGATTAAAATTTTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCGGATGT
GATGCAAGTATTTGATGGAGATGAAGGTCTTTACGAAGCTGAAAGTGGTGTTTATGATTTGATTCTTTTGGACTTAATGT
TACCTGAAAAAGATGGTTTTACAGTTCTTAAAGAATTGCGTGAACAAGGAATAACGACTCCTATTCTTATCATGACTGCT
AAGGAAAGTCTAGACGATAAGGGGCATGGCTTCGAACTCGGAGCTGATGATTATCTAACCAAGCCTTTCTATTTAAAAGA
ATTGAAGATGCGTATTGAGGCACTTTTGAAACGTTCTGGTAAATTTGATCAAAATACTTTTTCTTTTGGAGATGTTTGTG
TCAACCTTTCTACAAATTCAACTTATGTGGGTGATAAAGAAGTAGAACTTCTTGGTAAAGAATTTGATTTATTAGTCTAC
TTCCTACAAAATCAAAACGTTATTTTGCCCAAGTCGCAAATCTTTGATCGTCTTTGGGGATTTGATAGTGATACCAATGT
CTCTGTTGTTGAAGTTTATGTTTCGAAAATTCGTAAGAAACTTAAGGGGACTGATTTTGCTACCAACCTACAAACCTTAA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

86.099

99.554

0.857
  ciaR Streptococcus pneumoniae D39

86.099

99.554

0.857
  ciaR Streptococcus pneumoniae R6

86.099

99.554

0.857
  ciaR Streptococcus pneumoniae TIGR4

86.099

99.554

0.857
  ciaR Streptococcus mutans UA159

84.375

100

0.844
  vicR Streptococcus mutans UA159

35.593

100

0.375
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.333

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.169

100

0.371