Detailed information NTG0510541

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: STR1_RS04820
• Genome accession: NZ_CP065486
• Coordinates: 921454..922179 (+)
• Length: 241 a.a.
• NCBI ID: WP_101415611.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus strain R1
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 916454..927179

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STR1_RS04785 (STR1_04785)	-	916547..916729 (+)	183	WP_006531883.1	Blp family class II bacteriocin	-
STR1_RS04790 (STR1_04790)	-	917346..917576 (+)	231	WP_043878356.1	bacteriocin	-
STR1_RS04795 (STR1_04795)	-	917665..917976 (+)	312	WP_003066586.1	hypothetical protein	-
STR1_RS04800 (STR1_04800)	-	918190..918282 (+)	93	Protein_901	Blp family class II bacteriocin	-
STR1_RS04805 (STR1_04805)	-	918340..918744 (+)	405	WP_015695682.1	hypothetical protein	-
STR1_RS04810 (STR1_04810)	-	918925..919971 (+)	1047	WP_095559358.1	thioredoxin fold domain-containing protein	-
STR1_RS04815 (STR1_04815)	-	920503..921267 (+)	765	WP_232086163.1	DUF6261 family protein	-
STR1_RS04820 (STR1_04820)	comE/comE1	921454..922179 (+)	726	WP_101415611.1	response regulator transcription factor	Regulator
STR1_RS04825 (STR1_04825)	-	922192..923511 (+)	1320	WP_095559360.1	GHKL domain-containing protein	-
STR1_RS04830 (STR1_04830)	-	923532..923681 (-)	150	WP_006531893.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
STR1_RS04840 (STR1_04840)	-	924208..924792 (+)	585	WP_232086162.1	hypothetical protein	-
STR1_RS04845 (STR1_04845)	csm6	924807..925898 (+)	1092	WP_095559361.1	type III-A CRISPR-associated CARF protein Csm6	-
STR1_RS04850 (STR1_04850)	pyrF	926099..926794 (+)	696	WP_011681116.1	orotidine-5'-phosphate decarboxylase	-

Sequence

Protein

• Length: 241 a.a.
• Molecular weight: 28093.06 Da
• Isoelectric Point: 5.0805

>NTDB_id=510541 STR1_RS04820 WP_101415611.1 921454..922179(+) (comE/comE1) [Streptococcus thermophilus strain R1]
MDIFVLEDDIPQQFRMERAINLVMESNNWHYRYLEISSNPDEIIAVAGNGEHQIFFLDLEIKGEEQQGIDVAKAIREKNS
TAIIVFVTTHSEFMLLTYQSLVGAIDFIDKGLNEEAFNERLFVCLKEAVKRQEGNFGEHSYLFHTPQAKVRVAYDDILFF
ETSPAPHRIILHTKNERTEFYATIAEVAKSDERLFRCHRSFVVNVDNIARFDMRYKLIYFEMGETCPVARAKVKLLQEKI
E

Nucleotide

• Length: 726 bp

>NTDB_id=510541 STR1_RS04820 WP_101415611.1 921454..922179(+) (comE/comE1) [Streptococcus thermophilus strain R1]
GTGGATATTTTTGTACTCGAAGATGATATTCCCCAACAATTCCGAATGGAGCGTGCTATTAATCTTGTGATGGAATCAAA
TAACTGGCATTATCGGTATTTGGAGATTTCATCTAATCCTGATGAAATCATCGCAGTAGCAGGTAATGGTGAACATCAAA
TTTTCTTTCTTGATTTAGAAATTAAAGGTGAAGAGCAGCAAGGGATTGATGTTGCTAAAGCTATTCGTGAAAAAAATAGC
ACAGCTATTATTGTTTTTGTGACGACACATTCTGAATTCATGCTCTTAACCTATCAATCTTTAGTAGGTGCTATTGACTT
TATTGACAAAGGATTAAACGAAGAAGCGTTTAATGAACGCTTATTCGTTTGTCTTAAAGAAGCTGTCAAACGCCAAGAGG
GAAACTTTGGTGAACATTCCTACTTGTTTCATACCCCACAAGCCAAAGTGCGGGTAGCTTATGATGATATTTTATTTTTT
GAAACGTCACCAGCACCTCATCGTATTATTTTGCACACTAAGAACGAACGTACAGAATTTTATGCGACCATAGCAGAAGT
GGCAAAATCAGATGAACGTCTTTTTAGATGTCATCGTTCTTTTGTGGTTAACGTGGATAATATCGCTAGATTTGATATGA
GGTATAAGCTCATTTATTTTGAGATGGGAGAAACCTGTCCTGTAGCTAGGGCTAAGGTGAAATTATTACAGGAGAAAATT
GAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-120)

• LytTr DNA-binding domain (LytTR) (150-240)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	65.823	98.34	0.647
comE/blpR	Streptococcus mutans UA159	46.281	100	0.465
comE/comE2	Streptococcus equinus JB1	44.398	100	0.444
comE/comE2	Streptococcus gordonii strain NCTC7865	35.06	100	0.365
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	35.06	100	0.365
agrA	Staphylococcus aureus N315	35.656	100	0.361