Detailed information NTG0510487

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: STMM20_RS06095
• Genome accession: NZ_CP065485
• Coordinates: 1190614..1191288 (-)
• Length: 224 a.a.
• NCBI ID: WP_113870373.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus strain MM20
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1185614..1196288

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STMM20_RS06070 (STMM20_06090)	-	1185707..1186981 (-)	1275	Protein_1163	pyrimidine-nucleoside phosphorylase	-
STMM20_RS06075 (STMM20_06095)	-	1186978..1187568 (-)	591	WP_014727541.1	class I SAM-dependent methyltransferase	-
STMM20_RS06080 (STMM20_06100)	coaA	1187893..1188813 (+)	921	WP_347103483.1	type I pantothenate kinase	-
STMM20_RS06085 (STMM20_06105)	rpsT	1188882..1189118 (+)	237	WP_002947597.1	30S ribosomal protein S20	-
STMM20_RS06090	-	1189207..1190624 (-)	1418	Protein_1167	HAMP domain-containing sensor histidine kinase	-
STMM20_RS06095 (STMM20_06125)	ciaR	1190614..1191288 (-)	675	WP_113870373.1	response regulator transcription factor	Regulator
STMM20_RS06100 (STMM20_06130)	-	1191475..1193145 (-)	1671	WP_024704082.1	formate--tetrahydrofolate ligase	-
STMM20_RS06105 (STMM20_06135)	-	1193339..1194022 (+)	684	WP_002948206.1	phosphopantothenate--cysteine ligase	-
STMM20_RS06110 (STMM20_06140)	coaC	1194015..1194560 (+)	546	WP_014608202.1	phosphopantothenoylcysteine decarboxylase	-
STMM20_RS06115 (STMM20_06145)	-	1194588..1195160 (+)	573	WP_347103694.1	ECF transporter S component	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25418.05 Da
• Isoelectric Point: 4.2405

>NTDB_id=510487 STMM20_RS06095 WP_113870373.1 1190614..1191288(-) (ciaR) [Streptococcus thermophilus strain MM20]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLKELREQGITTPILIMTA
KESLDDKGHGFELGADDYLTKPFYLKELKMRIEALLKRSGKFDQNTFSFGDVCVNLSTNSTYVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTNVSVVEVYVSKIRKKLKGTDFATNLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=510487 STMM20_RS06095 WP_113870373.1 1190614..1191288(-) (ciaR) [Streptococcus thermophilus strain MM20]
ATGATTAAAATTTTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCGGATGT
GATGCAAGTATTTGATGGAGATGAAGGTCTTTACGAAGCTGAAAGTGGTGTTTATGATTTGATTCTTTTGGACTTAATGT
TACCTGAAAAAGATGGTTTTACAGTTCTTAAAGAATTGCGTGAACAAGGAATAACGACTCCTATTCTTATCATGACTGCT
AAGGAAAGTCTAGACGATAAGGGGCATGGCTTCGAACTCGGAGCTGATGATTATCTAACCAAGCCTTTCTATTTAAAAGA
ATTGAAGATGCGTATTGAGGCACTTTTGAAACGTTCTGGTAAATTTGATCAAAATACTTTTTCTTTTGGAGATGTTTGTG
TCAACCTTTCTACAAATTCAACTTATGTGGGTGATAAAGAAGTAGAACTTCTTGGTAAAGAATTTGATTTATTAGTCTAC
TTCCTACAAAATCAAAACGTTATTTTGCCCAAGTCGCAAATCTTTGATCGTCTTTGGGGATTTGATAGTGATACCAATGT
CTCTGTTGTTGAAGTTTATGTTTCGAAAATTCGTAAGAAACTTAAGGGGACTGATTTTGCTACCAACCTACAAACCTTAA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	86.099	99.554	0.857
ciaR	Streptococcus pneumoniae D39	86.099	99.554	0.857
ciaR	Streptococcus pneumoniae R6	86.099	99.554	0.857
ciaR	Streptococcus pneumoniae TIGR4	86.099	99.554	0.857
ciaR	Streptococcus mutans UA159	84.375	100	0.844
vicR	Streptococcus mutans UA159	35.593	100	0.375
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.333	100	0.375
micA	Streptococcus pneumoniae Cp1015	35.169	100	0.371