Detailed information NTG0510189

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: ST90729_RS04640
• Genome accession: NZ_CP065480
• Coordinates: 880383..881222 (+)
• Length: 279 a.a.
• NCBI ID: WP_011227155.1
• Uniprot ID: A0A3G6JMX3
• Organism: Streptococcus thermophilus strain 90729
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 875383..886222

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST90729_RS04610 (ST90729_04595)	-	875798..876325 (+)	528	WP_041827017.1	ECF transporter S component	-
ST90729_RS04615 (ST90729_04600)	-	876349..876864 (+)	516	WP_232975968.1	transcription repressor NadR	-
ST90729_RS04620 (ST90729_04605)	-	876959..877648 (+)	690	WP_179967039.1	helix-turn-helix transcriptional regulator	-
ST90729_RS04625 (ST90729_04610)	ylqF	877776..878630 (+)	855	WP_022096554.1	ribosome biogenesis GTPase YlqF	-
ST90729_RS04630 (ST90729_04615)	-	878617..879384 (+)	768	WP_347116814.1	ribonuclease HII	-
ST90729_RS04635 (ST90729_04620)	-	879395..880315 (+)	921	WP_002950604.1	ROK family protein	-
ST90729_RS04640 (ST90729_04625)	dprA	880383..881222 (+)	840	WP_011227155.1	DNA-processing protein DprA	Machinery gene
ST90729_RS04645 (ST90729_04630)	topA	881390..883534 (+)	2145	WP_232974459.1	type I DNA topoisomerase	-
ST90729_RS04650 (ST90729_04635)	-	883652..884476 (+)	825	WP_011227157.1	TraX family protein	-
ST90729_RS04655 (ST90729_04640)	-	884512..885171 (+)	660	WP_011227158.1	response regulator transcription factor	-

Sequence

Protein

• Length: 279 a.a.
• Molecular weight: 31233.11 Da
• Isoelectric Point: 8.4489

>NTDB_id=510189 ST90729_RS04640 WP_011227155.1 880383..881222(+) (dprA) [Streptococcus thermophilus strain 90729]
MNNFELFKLKAAGLTNLNILNILDYQKNQDKKLSLRDMAVVSKSKNAVLFMEKYKNLDVNQLKEDFQRFPTLSIFDKEYP
IELKHSYNPPVLLFYQGNIDLLSKPKLAVVGARKCSETGKQSVRKIVHELGNAFTIVSGLARGIDTCAHMEALKNKGNTI
AVIGTGLDVYYPKENKALQDYMAKNHLVLTEYGPGEQPLKYHYPERNRIISGLCQGVMVVEAKLRSGSLITCERAMEEGR
DVFAIPGNILDGKSDGCHHLIQEGAKCITTGFDIISEFS

Nucleotide

• Length: 840 bp

>NTDB_id=510189 ST90729_RS04640 WP_011227155.1 880383..881222(+) (dprA) [Streptococcus thermophilus strain 90729]
ATGAATAACTTTGAACTTTTTAAACTAAAAGCTGCTGGATTGACGAATTTAAACATCCTTAACATTTTAGACTATCAAAA
AAATCAAGATAAAAAATTGAGCTTACGTGATATGGCAGTGGTATCTAAGTCTAAAAATGCCGTTCTCTTTATGGAAAAAT
ACAAGAATTTAGATGTTAATCAGCTTAAGGAAGATTTTCAACGTTTTCCGACCTTATCAATTTTTGATAAGGAGTATCCC
ATTGAGCTGAAACATTCCTATAATCCTCCTGTCCTCCTCTTTTATCAAGGGAATATTGATTTGCTAAGTAAACCCAAGTT
AGCAGTAGTTGGTGCCAGAAAGTGTTCTGAAACAGGAAAACAGTCTGTTCGAAAAATTGTTCATGAACTTGGGAATGCCT
TTACTATTGTAAGTGGCTTGGCACGTGGAATTGATACTTGTGCTCATATGGAGGCCTTAAAAAATAAAGGTAACACCATT
GCAGTTATCGGGACTGGGCTAGACGTATATTATCCTAAAGAAAACAAAGCTTTACAGGACTATATGGCTAAAAATCATTT
AGTTCTTACAGAATACGGACCTGGTGAACAGCCACTTAAATACCATTATCCTGAACGAAATCGGATAATTTCTGGATTGT
GTCAAGGGGTTATGGTGGTTGAAGCCAAGCTTCGCTCGGGAAGTCTTATTACTTGTGAGCGTGCAATGGAAGAAGGAAGA
GATGTTTTCGCCATACCAGGAAATATTTTAGATGGAAAATCGGATGGATGCCATCACCTCATTCAAGAGGGCGCAAAGTG
CATTACTACAGGATTTGACATCATTTCAGAATTTTCATAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (71-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A3G6JMX3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	71.685	100	0.717
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae D39	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae R6	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	62.95	99.642	0.627
dprA/cilB/dalA	Streptococcus mitis SK321	62.95	99.642	0.627
dprA	Lactococcus lactis subsp. cremoris KW2	60.072	99.642	0.599
dprA	Latilactobacillus sakei subsp. sakei 23K	39.768	92.832	0.369
dprA	Bacillus subtilis subsp. subtilis str. 168	48.095	75.269	0.362