Detailed information NTG0509933

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ST4052_RS01470
• Genome accession: NZ_CP065476
• Coordinates: 267380..268279 (+)
• Length: 299 a.a.
• NCBI ID: WP_011225448.1
• Uniprot ID: Q5M612
• Organism: Streptococcus thermophilus strain 4052
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 262380..273279

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST4052_RS01450 (ST4052_01455)	trkA	263506..264855 (-)	1350	WP_011225444.1	Trk system potassium transporter TrkA	-
ST4052_RS01455 (ST4052_01460)	-	265143..265652 (+)	510	WP_011680717.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
ST4052_RS01460 (ST4052_01465)	-	265964..266521 (+)	558	WP_002949523.1	ECF transporter S component	-
ST4052_RS01465 (ST4052_01470)	-	266524..267174 (+)	651	WP_011225447.1	phosphatase PAP2 family protein	-
ST4052_RS01470 (ST4052_01475)	comR	267380..268279 (+)	900	WP_011225448.1	helix-turn-helix domain-containing protein	Regulator
ST4052_RS01475 (ST4052_01480)	-	268517..269695 (+)	1179	Protein_237	ABC transporter transmembrane domain-containing protein	-
ST4052_RS01480 (ST4052_01495)	-	269981..270549 (+)	569	Protein_238	ATP-binding cassette domain-containing protein	-
ST4052_RS01485 (ST4052_01500)	-	270657..270968 (+)	312	WP_011226857.1	DUF805 domain-containing protein	-
ST4052_RS01490	-	270936..271220 (-)	285	WP_231108755.1	hypothetical protein	-
ST4052_RS01495	-	271460..271762 (-)	303	WP_011226859.1	hypothetical protein	-
ST4052_RS01500	-	271986..272357 (-)	372	WP_231108754.1	hypothetical protein	-
ST4052_RS01505 (ST4052_01510)	-	272762..273277 (+)	516	WP_011226861.1	AmiS/UreI family transporter	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35303.77 Da
• Isoelectric Point: 5.1073

>NTDB_id=509933 ST4052_RS01470 WP_011225448.1 267380..268279(+) (comR) [Streptococcus thermophilus strain 4052]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=509933 ST4052_RS01470 WP_011225448.1 267380..268279(+) (comR) [Streptococcus thermophilus strain 4052]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAAATCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (75-292)

• Helix-turn-helix (HTH_3) (11-66)

3D structure

• AlphaFold DB: Q5M612

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	100	100	1
comR	Streptococcus thermophilus LMD-9	99.331	100	0.993
comR	Streptococcus salivarius strain HSISS4	95.318	100	0.953
comR	Streptococcus salivarius SK126	94.649	100	0.946
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421