Detailed information NTG0507736

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: I2438_RS00290
• Genome accession: NZ_CP065190
• Coordinates: 47706..48620 (+)
• Length: 304 a.a.
• NCBI ID: WP_012514714.1
• Uniprot ID: A0AAW3GQI0
• Organism: Streptococcus equi subsp. zooepidemicus strain SEZ36
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 42706..53620

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I2438_RS00265 (HCFMJIKG_00052)	purE	43870..44358 (+)	489	WP_012514711.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
I2438_RS00270 (HCFMJIKG_00053)	purK	44345..45436 (+)	1092	WP_012514712.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
I2438_RS00275 (HCFMJIKG_00054)	-	45446..45670 (+)	225	WP_012514713.1	hypothetical protein	-
I2438_RS00280	-	45694..45798 (+)	105	WP_370444775.1	hypothetical protein	-
I2438_RS00285 (HCFMJIKG_00055)	purB	46115..47407 (+)	1293	WP_037583922.1	adenylosuccinate lyase	-
I2438_RS00290 (HCFMJIKG_00056)	comR	47706..48620 (+)	915	WP_012514714.1	helix-turn-helix domain-containing protein	Regulator
I2438_RS10510 (HCFMJIKG_00057)	comS	48703..48801 (+)	99	WP_021320241.1	quorum-sensing system DWW-type pheromone	Regulator
I2438_RS00295 (HCFMJIKG_00058)	ruvB	48835..49836 (+)	1002	WP_012514715.1	Holliday junction branch migration DNA helicase RuvB	-
I2438_RS00300 (HCFMJIKG_00059)	-	50122..50580 (+)	459	WP_012514717.1	low molecular weight protein-tyrosine-phosphatase	-
I2438_RS00305 (HCFMJIKG_00060)	-	50586..50987 (+)	402	WP_012514718.1	MORN repeat-containing protein	-
I2438_RS00310 (HCFMJIKG_00061)	-	50984..52765 (+)	1782	WP_021320242.1	acyltransferase family protein	-

Sequence

Protein

• Length: 304 a.a.
• Molecular weight: 35823.41 Da
• Isoelectric Point: 4.5517

>NTDB_id=507736 I2438_RS00290 WP_012514714.1 47706..48620(+) (comR) [Streptococcus equi subsp. zooepidemicus strain SEZ36]
MLDNFGEKVRDLRYQKKITREDLCGDESELSIRQLARIELGQSIPSLSKVVYIAKALDVSVGFLTDGEDLELPKRYKELK
YLILRTPTYMDDDKLKLREEQFDEIFEDYYDQLPEEEKLVVDCLQSIMDTLLTENINFGVGLLQEYFEQTKSKTQFREND
LILIELYLAYLDIVGMNGEYSDKGFYDSLLDILLNQFEHFELEELFIVNKIAIGISSLSIKSNKLEILEKVIVLSQKIIL
KTQDFNRMPILNLIEWKYALMKKKDIEMAKKCYDKACLFAQLTGDQYLEKKLREEWGKDIKRYQ

Nucleotide

• Length: 915 bp

>NTDB_id=507736 I2438_RS00290 WP_012514714.1 47706..48620(+) (comR) [Streptococcus equi subsp. zooepidemicus strain SEZ36]
ATGTTAGACAATTTTGGTGAAAAGGTGAGAGACCTTCGGTATCAGAAAAAAATTACCAGAGAGGATTTATGTGGAGATGA
GTCAGAATTATCCATTCGTCAATTGGCACGAATAGAACTGGGCCAATCGATTCCCAGCCTATCAAAGGTGGTTTATATTG
CTAAGGCTCTGGACGTTAGTGTCGGCTTTTTGACAGACGGAGAGGATTTGGAGCTGCCTAAGCGTTATAAAGAACTTAAA
TATTTGATTTTAAGAACGCCGACCTATATGGATGATGACAAATTAAAGCTGCGAGAAGAGCAATTTGACGAAATTTTTGA
AGATTATTATGACCAGTTGCCAGAGGAAGAAAAGCTTGTGGTGGACTGCTTGCAGTCCATAATGGATACGTTATTAACCG
AGAATATCAATTTTGGAGTTGGGTTATTACAGGAATACTTTGAACAGACAAAAAGCAAGACTCAATTTAGAGAGAATGAC
CTTATTCTTATTGAGCTGTATTTAGCGTATCTGGATATTGTGGGAATGAATGGAGAGTATTCAGATAAAGGATTCTATGA
TTCTTTATTAGACATTTTGTTAAATCAGTTTGAACATTTTGAATTAGAGGAATTATTTATCGTCAATAAAATAGCTATAG
GGATTTCCTCGTTGAGCATCAAAAGCAATAAGCTGGAGATTCTTGAGAAGGTTATTGTGCTTAGTCAAAAAATTATTCTC
AAGACTCAGGATTTCAATAGAATGCCTATCTTAAATTTGATAGAGTGGAAATACGCTTTAATGAAGAAAAAAGACATAGA
AATGGCCAAAAAATGCTATGATAAGGCATGCCTGTTTGCTCAATTAACAGGAGATCAGTATTTGGAAAAGAAATTGAGAG
AAGAATGGGGTAAAGATATAAAACGATATCAATAG

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (10-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	74.257	99.671	0.74
comR	Streptococcus pyogenes MGAS315	54.485	99.013	0.539
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.379	95.395	0.49
comR	Streptococcus mutans UA159	49.498	98.355	0.487
comR	Streptococcus suis P1/7	38.591	98.026	0.378
comR	Streptococcus suis 05ZYH33	38.644	97.039	0.375
comR	Streptococcus suis D9	37.037	97.697	0.362