Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SMULJ23_RS04730 Genome accession   NC_017768
Coordinates   964078..964752 (+) Length   224 a.a.
NCBI ID   WP_002264509.1    Uniprot ID   -
Organism   Streptococcus mutans LJ23     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 959078..969752
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMULJ23_RS04710 (SMULJ23_0906) pstB 959330..960088 (+) 759 WP_002262210.1 phosphate ABC transporter ATP-binding protein PstB -
  SMULJ23_RS04715 (SMULJ23_0907) phoU 960120..960773 (+) 654 WP_002262211.1 phosphate signaling complex protein PhoU -
  SMULJ23_RS04720 (SMULJ23_0908) - 960814..963363 (+) 2550 WP_014677981.1 M1 family metallopeptidase -
  SMULJ23_RS04725 (SMULJ23_0909) ciaX 963764..964027 (+) 264 WP_002268040.1 three-component system regulator CiaX -
  SMULJ23_RS04730 (SMULJ23_0910) ciaR 964078..964752 (+) 675 WP_002264509.1 three-component system response regulator CiaR Regulator
  SMULJ23_RS04735 (SMULJ23_0911) ciaH 964742..966049 (+) 1308 WP_002264510.1 three-component system sensor histidine kinase CiaH Regulator
  SMULJ23_RS04740 (SMULJ23_0912) rpsT 966138..966392 (-) 255 WP_011074586.1 30S ribosomal protein S20 -
  SMULJ23_RS04745 (SMULJ23_0913) coaA 966446..967366 (-) 921 WP_002262217.1 type I pantothenate kinase -
  SMULJ23_RS04750 (SMULJ23_0914) - 967462..968058 (+) 597 WP_002268746.1 class I SAM-dependent methyltransferase -
  SMULJ23_RS04755 (SMULJ23_0915) - 968167..969444 (+) 1278 WP_014677982.1 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25417.19 Da        Isoelectric Point: 4.3777

>NTDB_id=50759 SMULJ23_RS04730 WP_002264509.1 964078..964752(+) (ciaR) [Streptococcus mutans LJ23]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGAEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN

Nucleotide


Download         Length: 675 bp        

>NTDB_id=50759 SMULJ23_RS04730 WP_002264509.1 964078..964752(+) (ciaR) [Streptococcus mutans LJ23]
ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGT
CATGCAGGTTTTTGATGGTGCAGAAGGACTGTATGAAGCAGAGAGTGGCGTTTATGATTTGATTCTATTAGACTTAATGC
TTCCTGAAAAAAATGGCTTCCAAGTTTTAAAAGAACTGCGTGAAAAAGGGATAACGACACCTGTTTTAATTATGACAGCT
AAGGAAGGTTTGGATGACAAAGGACACGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTTTATCTTGAAGA
ATTAAAAATGCGTATTCAGGCCCTCCTCAAACGTTCAGGCAAATTCAACGAAAATAATCTGACTTACGGTGAGTTAACCG
TTGATACAGCAACTAATACAACAATGGTAAATGGAAAAGAAGTTGAACTGCTTGGCAAAGAGTTTGACTTATTAGTTTAT
TTCTTACAAAATCAAAATGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGCGATACGACAAT
TTCGGTTGTTGAAGTCTATGTTTCTAAAATAAGAAAAAAATTAAAAGATACCACATTTGGAAAGAATTTACAGACATTAC
GCAGTGTAGGATATATTTTGAAGGATGCTAATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

99.554

100

0.996
  ciaR Streptococcus pneumoniae Rx1

87.946

100

0.879
  ciaR Streptococcus pneumoniae D39

87.946

100

0.879
  ciaR Streptococcus pneumoniae R6

87.946

100

0.879
  ciaR Streptococcus pneumoniae TIGR4

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.611

100

0.379
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment