Detailed information NTG0506608

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: I2437_RS05140
• Genome accession: NZ_CP065061
• Coordinates: 1055009..1055683 (-)
• Length: 224 a.a.
• NCBI ID: WP_012515548.1
• Uniprot ID: B4U2R0
• Organism: Streptococcus equi subsp. zooepidemicus strain SEZ33
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1050009..1060683

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I2437_RS05105 (IEMOCGPF_01022)	-	1050401..1050685 (-)	285	WP_165628099.1	hypothetical protein	-
I2437_RS05110 (IEMOCGPF_01023)	-	1050705..1051106 (-)	402	WP_206157696.1	hypothetical protein	-
I2437_RS05115 (IEMOCGPF_01024)	-	1051103..1052302 (-)	1200	WP_206157697.1	hypothetical protein	-
I2437_RS05120 (IEMOCGPF_01025)	-	1052304..1052687 (-)	384	WP_165628096.1	hypothetical protein	-
I2437_RS05125 (IEMOCGPF_01026)	-	1052611..1052901 (-)	291	WP_165628095.1	hypothetical protein	-
I2437_RS05130 (IEMOCGPF_01027)	-	1052902..1053321 (-)	420	WP_165628094.1	hypothetical protein	-
I2437_RS05135 (IEMOCGPF_01028)	ciaH	1053706..1055016 (-)	1311	WP_206157698.1	HAMP domain-containing sensor histidine kinase	Regulator
I2437_RS05140 (IEMOCGPF_01029)	ciaR	1055009..1055683 (-)	675	WP_012515548.1	response regulator transcription factor	Regulator
I2437_RS05145 (IEMOCGPF_01030)	-	1056102..1058639 (-)	2538	WP_165627478.1	M1 family metallopeptidase	-
I2437_RS05150 (IEMOCGPF_01031)	phoU	1058869..1059522 (-)	654	WP_206158033.1	phosphate signaling complex protein PhoU	-
I2437_RS05155 (IEMOCGPF_01032)	pstB	1059593..1060351 (-)	759	WP_012678019.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25541.52 Da
• Isoelectric Point: 4.5644

>NTDB_id=506608 I2437_RS05140 WP_012515548.1 1055009..1055683(-) (ciaR) [Streptococcus equi subsp. zooepidemicus strain SEZ33]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKDGFQVLKALREKDIKIPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRVGKFNDKSLKFGNLTVDTTRKEVQVNGQAIELLGKELDLLIY
ILQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTDFVNHLQTLRSVGYILKANE

Nucleotide

• Length: 675 bp

>NTDB_id=506608 I2437_RS05140 WP_012515548.1 1055009..1055683(-) (ciaR) [Streptococcus equi subsp. zooepidemicus strain SEZ33]
ATGATAAAACTATTATTAGTAGAAGACGATTTAAGTTTGTCAAATTCTATCTTTGATTTTTTAGATGACTTTGCTGATGT
GACGCAGGTTTTTGATGGTGACGAAGGACTCTATGAGGCAGAAAGCGGTATTTATGATTTGATTCTGTTAGATTTGATGC
TGCCTGAAAAGGATGGCTTTCAAGTGTTAAAAGCCTTACGTGAAAAAGACATCAAAATTCCCGTCTTGATCATGACTGCC
AAAGAAAGCATCGATGACAAGGGGCATGGCTTTGAGCTTGGTGCTGATGACTATTTAACCAAGCCCTTTTACCTAGAAGA
ATTAAAAATGCGGATTCAGGCCTTGCTTAAGCGCGTAGGAAAGTTTAATGACAAGAGCCTTAAATTTGGCAACCTGACTG
TAGATACTACCCGTAAAGAGGTACAGGTCAATGGGCAGGCCATAGAGCTATTAGGCAAAGAGCTTGATTTACTAATCTAT
ATCCTTCAAAATCAAAATGTTATTTTGCCAAAATCACAAATTTTTGATCGTATCTGGGGCTTTGATAGTGATACCACTAT
CTCTGTTGTAGAGGTCTATGTCTCTAAAATTCGTAAGAAGCTTAAGGGGACAGACTTTGTTAATCATCTTCAAACCTTGA
GAAGTGTAGGATATATCTTAAAAGCTAATGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: B4U2R0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	84.615	98.661	0.835
ciaR	Streptococcus pneumoniae Rx1	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae D39	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae R6	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae TIGR4	80.543	98.661	0.795
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.428	100	0.393
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362