Detailed information NTG0506532

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: I2436_RS02525
• Genome accession: NZ_CP065060
• Coordinates: 513357..515510 (+)
• Length: 717 a.a.
• NCBI ID: WP_012515169.1
• Uniprot ID: A0A2X3T8J4
• Organism: Streptococcus equi subsp. zooepidemicus strain SEZ28
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 508357..520510

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I2436_RS02500 (GDAKBCAL_00498)	metG	508583..510565 (+)	1983	WP_206152982.1	methionine--tRNA ligase	-
I2436_RS02505 (GDAKBCAL_00499)	-	511123..512016 (+)	894	WP_206152984.1	XRE family transcriptional regulator	-
I2436_RS02510 (GDAKBCAL_00501)	-	512369..512509 (+)	141	WP_012515166.1	hypothetical protein	-
I2436_RS02515 (GDAKBCAL_00502)	-	512622..512780 (+)	159	WP_021320463.1	hypothetical protein	-
I2436_RS02520 (GDAKBCAL_00504)	-	512963..513130 (+)	168	WP_012515168.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
I2436_RS02525 (GDAKBCAL_00505)	comA	513357..515510 (+)	2154	WP_012515169.1	peptide cleavage/export ABC transporter ComA	Regulator
I2436_RS02530 (GDAKBCAL_00506)	comB	515525..516892 (+)	1368	WP_206152986.1	bacteriocin secretion accessory protein	Regulator
I2436_RS02535 (GDAKBCAL_00507)	-	517401..517637 (+)	237	WP_024273149.1	hypothetical protein	-
I2436_RS02540 (GDAKBCAL_00508)	nrdF	518095..519108 (+)	1014	WP_012678369.1	class 1b ribonucleoside-diphosphate reductase subunit beta	-
I2436_RS02545 (GDAKBCAL_00509)	nrdI	519110..519520 (+)	411	WP_043052823.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80481.42 Da
• Isoelectric Point: 9.0606

>NTDB_id=506532 I2436_RS02525 WP_012515169.1 513357..515510(+) (comA) [Streptococcus equi subsp. zooepidemicus strain SEZ28]
MKFRRKHYRAQVDTRDCGVASLAMIYGYYGSYYSLATLREAAKTTQEGTTAFGLVKVSEALGFETRAIRADMSLFDVEGL
SYPFIAHVLKKGKFLHYYVVTGQDKKYIHIADPDPTVKLTCLSRQRFASEWTGVTIFIAPTPEYKPHKEKKNSLLDFVPL
LAKQKGLITNIVVATLLVTIINIIGSYYLQSIIDTYVPSVMKNTLGIISVGLVIVYALQQVISYAQEYLLLILGQRLSID
VILSYIKHIFNLPMSFFATRRTGEIVSRFNDANSIIDALASTILSIFLDVSVIVIISLVLFSQNVNLFVISLLALPIYAV
IIFAFMKPFERMNQETMEANSIMSSSIIEDINGIETIKSLTSEKIRYQKIDKEFVAYLKKSFNYSRAESQQRALKKVAQL
ILNVSILWIGANLVMDGKMSLGQLITYNSLLIYFTNPLENIINLQTKLQTAQVANNRLNEVYLVESEFSEKKNVQDLSLT
SGDIKFNDVSYRYGYGKDVLSEINLHIKRGSKVAFVGISGSGKTTLAKMIVSFFEPSKGEISLNNVNLNQIDKHALRQHI
NYLPQQPYVFNGTILENLLLGAREGTTQEDIMKAVELAEIKSDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDS
PVLILDEATSNLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEHVVVLDKGKIIEQGTHRDLVSQNGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=506532 I2436_RS02525 WP_012515169.1 513357..515510(+) (comA) [Streptococcus equi subsp. zooepidemicus strain SEZ28]
ATGAAATTTAGAAGAAAACACTACCGTGCTCAGGTTGATACTCGCGATTGTGGCGTAGCTTCTCTGGCCATGATTTACGG
TTATTATGGATCGTATTATTCGCTAGCAACGTTACGTGAAGCTGCAAAGACAACGCAGGAAGGGACTACAGCTTTTGGTT
TAGTCAAAGTTTCTGAGGCGCTTGGGTTTGAAACGAGAGCTATTAGGGCTGACATGAGTTTATTTGATGTGGAAGGATTA
TCTTATCCTTTTATTGCCCATGTTCTAAAAAAAGGTAAGTTCCTTCATTATTATGTGGTAACAGGACAAGATAAAAAATA
TATTCATATTGCAGATCCAGATCCAACTGTAAAGTTGACTTGTCTTTCTCGTCAGCGATTTGCTTCAGAGTGGACAGGTG
TGACAATTTTTATCGCTCCTACTCCTGAATACAAACCTCACAAGGAAAAGAAAAATAGTCTGCTAGATTTTGTGCCTCTC
CTAGCAAAGCAAAAAGGATTGATTACTAATATCGTTGTGGCAACGCTTTTGGTAACGATTATCAATATTATTGGTTCGTA
TTATCTTCAATCAATCATTGATACCTATGTTCCTAGTGTGATGAAGAATACACTAGGTATTATTTCCGTAGGTTTGGTTA
TTGTCTATGCCCTTCAACAAGTGATCTCATATGCGCAAGAGTATTTATTGCTGATATTAGGGCAACGTTTATCTATTGAT
GTAATTCTTTCTTATATCAAACATATTTTCAACCTTCCTATGTCTTTTTTCGCGACGAGAAGGACCGGGGAAATTGTTTC
TCGTTTTAATGATGCTAATTCAATCATTGATGCTTTAGCAAGTACAATTTTATCTATTTTCCTTGATGTTTCTGTCATTG
TAATTATATCTCTTGTTCTTTTTTCGCAGAATGTAAATCTATTTGTTATCAGTTTGCTTGCTCTGCCTATCTATGCAGTG
ATTATCTTTGCCTTCATGAAGCCATTTGAACGGATGAATCAAGAGACAATGGAAGCAAATTCAATCATGTCATCTTCTAT
TATTGAAGATATAAACGGTATTGAGACTATTAAATCATTAACTAGCGAAAAGATAAGATACCAAAAAATAGATAAAGAAT
TTGTAGCTTATCTTAAGAAATCTTTCAACTATAGTAGGGCAGAAAGCCAACAACGAGCATTGAAAAAAGTAGCTCAGCTT
ATCCTAAACGTGAGCATACTCTGGATAGGAGCCAATCTGGTTATGGACGGAAAAATGAGTTTAGGTCAACTGATTACCTA
TAACTCTCTCCTAATCTACTTTACAAATCCTCTGGAGAATATTATCAATCTTCAAACGAAACTTCAAACCGCTCAAGTCG
CTAATAATCGATTGAATGAGGTATATCTAGTTGAATCCGAGTTCTCTGAAAAGAAGAATGTTCAAGACTTATCTTTGACC
TCTGGTGACATAAAATTCAATGATGTTAGCTATCGATATGGATATGGAAAAGATGTTTTATCAGAAATAAATTTGCATAT
TAAACGAGGAAGCAAGGTTGCTTTTGTTGGGATTTCAGGTTCTGGAAAAACGACTTTAGCTAAGATGATTGTCAGTTTCT
TTGAACCAAGCAAAGGCGAAATATCATTAAATAATGTGAATCTAAATCAAATTGACAAACATGCTCTTCGCCAGCACATT
AACTATCTTCCTCAACAACCTTACGTATTTAATGGGACAATCCTTGAGAATTTACTTCTTGGAGCACGTGAAGGGACGAC
TCAAGAAGACATTATGAAGGCAGTAGAATTGGCTGAAATCAAGTCTGATATTGAACGTATGCCTTTGAATTATCAAACAG
AGTTAACCTCAGATGGTGCAGGGATTTCTGGAGGTCAACGTCAACGTATTGCCTTAGCAAGGGCATTATTGACAGATTCT
CCTGTTTTGATATTAGACGAAGCTACAAGTAACTTGGATATTTTGACTGAGAAGCGAATTGTTGATAACCTGATGGCTTT
AGATAAAACCTTGATATTTATTGCTCACCGTTTAACTATTGCAGAGCGTACAGAGCATGTCGTCGTTTTGGATAAAGGAA
AGATCATAGAGCAAGGAACACACAGAGACCTTGTTTCTCAGAATGGCTTTTATGCTCACTTGGTCAATAGTTAG

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (500-650)

• ABC transporter transmembrane region (ABC_membrane) (169-438)

• Peptidase C39 family (Peptidase_C39) (6-142)

3D structure

• AlphaFold DB: A0A2X3T8J4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	82.148	100	0.821
comA	Streptococcus mitis SK321	81.729	100	0.817
comA	Streptococcus pneumoniae Rx1	81.729	100	0.817
comA	Streptococcus pneumoniae D39	81.729	100	0.817
comA	Streptococcus pneumoniae R6	81.729	100	0.817
comA	Streptococcus pneumoniae TIGR4	81.45	100	0.815
comA	Streptococcus gordonii str. Challis substr. CH1	78.661	100	0.787
comA/nlmT	Streptococcus mutans UA159	62.901	100	0.629