Detailed information NTG0506457

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: I2435_RS00290
• Genome accession: NZ_CP065059
• Coordinates: 49170..50084 (+)
• Length: 304 a.a.
• NCBI ID: WP_043039892.1
• Uniprot ID: A0A7Z8ZYG0
• Organism: Streptococcus equi subsp. zooepidemicus strain SEZ25
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 44170..55084

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I2435_RS00265 (JFMEOBDD_00053)	purK	44371..45450 (+)	1080	WP_206156519.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
I2435_RS00270 (JFMEOBDD_00054)	-	45517..46566 (+)	1050	WP_206156520.1	hypothetical protein	-
I2435_RS00275 (JFMEOBDD_00055)	-	46520..46894 (+)	375	WP_206156521.1	hypothetical protein	-
I2435_RS00280 (JFMEOBDD_00056)	-	46891..47577 (+)	687	WP_206156522.1	restriction endonuclease	-
I2435_RS00285 (JFMEOBDD_00057)	purB	47580..48872 (+)	1293	WP_206152283.1	adenylosuccinate lyase	-
I2435_RS00290 (JFMEOBDD_00058)	comR	49170..50084 (+)	915	WP_043039892.1	XRE family transcriptional regulator	Regulator
I2435_RS00300 (JFMEOBDD_00060)	ruvB	50299..51300 (+)	1002	WP_012514715.1	Holliday junction branch migration DNA helicase RuvB	-
I2435_RS00305 (JFMEOBDD_00061)	-	51548..52006 (+)	459	WP_012514717.1	low molecular weight protein-tyrosine-phosphatase	-
I2435_RS00310 (JFMEOBDD_00062)	-	52012..52413 (+)	402	WP_012514718.1	MORN repeat-containing protein	-
I2435_RS00315 (JFMEOBDD_00063)	-	52410..54191 (+)	1782	WP_043029239.1	acyltransferase family protein	-

Sequence

Protein

• Length: 304 a.a.
• Molecular weight: 35746.33 Da
• Isoelectric Point: 4.5886

>NTDB_id=506457 I2435_RS00290 WP_043039892.1 49170..50084(+) (comR) [Streptococcus equi subsp. zooepidemicus strain SEZ25]
MLDNFGEKVRDLRYQKKITREDLCGDESELSIRQLARIELGQSIPSLSKVVFIAKALDVSVGFLTDGEDLELPKRYKELK
YLILRTPTYMDDDKLKLREEQFDEIFEDYYDQLPEEEKLVVDCLQSIMDTLLTENINFGVGLLQEYFEQTKSKTQFREND
LILIELYLAYLDIAGMNGEYSDKGFYDSLLDILLNQFEHFELEELFIVNKIAIGISSLSIKNNKPEILEKVIVLSQKIIL
KTQDFNRMPILNLIEWKYALMKKKDIEMAKKCYAKACLFAQLTGDQYLEKKLREEWGKDIKRYQ

Nucleotide

• Length: 915 bp

>NTDB_id=506457 I2435_RS00290 WP_043039892.1 49170..50084(+) (comR) [Streptococcus equi subsp. zooepidemicus strain SEZ25]
ATGTTAGACAATTTTGGTGAAAAGGTGAGAGACCTGCGGTATCAGAAGAAGATTACCAGAGAGGATTTATGTGGAGATGA
GTCAGAATTATCCATTCGTCAATTAGCACGAATAGAATTGGGCCAATCGATTCCCAGCCTATCAAAGGTGGTTTTTATTG
CTAAGGCTCTGGACGTTAGTGTCGGCTTTTTGACAGACGGAGAGGATTTGGAGCTGCCTAAGCGTTATAAAGAACTTAAA
TATTTGATTTTAAGAACGCCGACCTATATGGATGATGACAAATTAAAGCTGCGAGAAGAGCAATTTGACGAAATTTTTGA
AGATTATTATGACCAGTTGCCAGAGGAAGAAAAGCTTGTGGTGGATTGCTTGCAGTCCATAATGGATACGTTATTAACCG
AGAATATCAATTTTGGAGTTGGGTTATTACAGGAATACTTTGAACAAACAAAAAGTAAGACTCAATTTAGAGAGAATGAT
CTCATTCTTATTGAGCTGTATTTAGCGTACCTCGACATTGCAGGAATGAATGGAGAGTATTCAGATAAAGGATTCTATGA
TTCTTTGTTAGACATTTTGTTAAATCAGTTTGAACATTTTGAATTAGAGGAATTATTTATTGTCAATAAAATAGCTATAG
GAATTTCCTCGTTGAGCATCAAAAACAATAAGCCGGAGATTCTTGAGAAGGTTATTGTACTTAGTCAAAAAATTATCCTC
AAGACTCAGGATTTTAATAGAATGCCTATCTTAAATTTGATAGAGTGGAAATATGCTCTAATGAAGAAAAAAGACATAGA
AATGGCCAAAAAATGCTATGCTAAGGCATGCCTGTTTGCTCAATTAACAGGAGATCAGTATTTGGAAAAGAAATTGAGAG
AAGAATGGGGTAAAGATATAAAACGATATCAATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix domain (HTH_19) (6-69)

• ComR tetratricopeptide (ComR_TPR) (73-296)

3D structure

• AlphaFold DB: A0A7Z8ZYG0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	74.587	99.671	0.743
comR	Streptococcus pyogenes MGAS315	54.817	99.013	0.543
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	52.069	95.395	0.497
comR	Streptococcus mutans UA159	48.829	98.355	0.48
comR	Streptococcus suis P1/7	38.255	98.026	0.375
comR	Streptococcus suis D9	37.542	99.013	0.372
comR	Streptococcus suis 05ZYH33	38.305	97.039	0.372