Detailed information NTG0506413

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: I2434_RS02640
• Genome accession: NZ_CP065058
• Coordinates: 543489..545642 (+)
• Length: 717 a.a.
• NCBI ID: WP_165623590.1
• Uniprot ID: -
• Organism: Streptococcus equi subsp. zooepidemicus strain SEZ18
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	540735..551871	543489..545642	within	0

Gene organization within MGE regions

Location: 540735..551871

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I2434_RS02615 (MCPGFBBE_00519)	-	540735..541994 (-)	1260	WP_111677636.1	ISL3-like element ISSeq1 family transposase	-
I2434_RS02620 (MCPGFBBE_00521)	-	542501..542641 (+)	141	WP_012515166.1	hypothetical protein	-
I2434_RS02625 (MCPGFBBE_00522)	-	542754..542912 (+)	159	WP_021320463.1	hypothetical protein	-
I2434_RS02630 (MCPGFBBE_00523)	-	542926..543072 (+)	147	WP_021320464.1	hypothetical protein	-
I2434_RS02635 (MCPGFBBE_00524)	-	543095..543262 (+)	168	WP_012515168.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
I2434_RS02640 (MCPGFBBE_00525)	comA	543489..545642 (+)	2154	WP_165623590.1	peptide cleavage/export ABC transporter ComA	Regulator
I2434_RS02645 (MCPGFBBE_00526)	comB	545657..547024 (+)	1368	WP_012515170.1	bacteriocin secretion accessory protein	Regulator
I2434_RS02650 (MCPGFBBE_00527)	-	547533..547769 (+)	237	WP_024273149.1	hypothetical protein	-
I2434_RS02655 (MCPGFBBE_00528)	nrdF	548226..549239 (+)	1014	WP_043040212.1	class 1b ribonucleoside-diphosphate reductase subunit beta	-
I2434_RS02660 (MCPGFBBE_00529)	nrdI	549241..549651 (+)	411	WP_043052823.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
I2434_RS02665 (MCPGFBBE_00530)	nrdE	549697..551871 (+)	2175	WP_021320467.1	class 1b ribonucleoside-diphosphate reductase subunit alpha	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80497.46 Da
• Isoelectric Point: 9.0606

>NTDB_id=506413 I2434_RS02640 WP_165623590.1 543489..545642(+) (comA) [Streptococcus equi subsp. zooepidemicus strain SEZ18]
MKFRRKHYRAQVDTRDCGVASLAMIYGYYGSYYSLATLREAAKTTQEGTTAFGLVKVSEALGFETRAIRADMSLFDVEGL
SYPFIAHVLKKGKFLHYYVVTGQDKKYIHIADPDPTVKLTCLSRQRFASEWTGVTIFIAPTPEYKPHKEKKNSLLDFVPL
LAKQKGLITNIVVATLLVTIINIIGSYYLQSIIDTYVPSVMKNTLGIISVGLVIVYALQQVISYAQEYLLLILGQRLSID
VILSYIKHIFNLPMSFFATRRTGEIVSRFNDANSIIDALASTILSIFLDVSVIVIISLVLFSQNVNLFVISLLALPIYAV
IIFAFMKPFERMNQETMEANSIMSSSIIEDINGIETIKSLTSEKIRYQKIDKEFVAYLKKSFNYSRAESQQRALKKVAQL
ILNVSILWIGANLVMDGKMSLGQLITYNSLLIYFTNPLENIINLQTKLQTAQVANNRLNEVYLVESEFSEKKNVQDLSLT
SGDIKFNDVSYRYGYGKDVLSEINLHIKRGSKVAFVGISGSGKTTLAKMIVSFFELSKGEISLNNVNLNQIDKHALRQHI
NYLPQQPYVFNGTILENLLLGAREGTTQEDIMKAVELAEIKSDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDS
PVLILDEATSNLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEHVVVLDKGKIIEQGTHRDLVSQNGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=506413 I2434_RS02640 WP_165623590.1 543489..545642(+) (comA) [Streptococcus equi subsp. zooepidemicus strain SEZ18]
ATGAAATTTAGAAGAAAACACTACCGTGCTCAGGTTGATACTCGCGATTGTGGCGTAGCTTCTCTGGCCATGATTTACGG
TTATTATGGATCGTATTATTCGCTAGCAACGTTACGTGAAGCTGCAAAGACAACGCAGGAAGGGACTACAGCTTTTGGTT
TAGTCAAAGTTTCTGAGGCGCTTGGGTTTGAAACGAGAGCTATTAGGGCTGACATGAGTTTATTTGATGTGGAAGGATTA
TCTTATCCTTTTATTGCCCATGTTCTAAAAAAAGGTAAGTTCCTTCATTATTATGTGGTAACAGGACAAGATAAAAAATA
TATTCATATTGCAGATCCAGATCCAACTGTAAAGTTGACTTGTCTTTCTCGTCAGCGATTTGCTTCAGAGTGGACAGGTG
TGACAATTTTTATCGCTCCTACTCCTGAATACAAACCTCACAAGGAAAAGAAAAATAGTCTGCTAGATTTTGTGCCTCTC
CTAGCAAAGCAAAAAGGATTGATTACTAATATCGTTGTGGCAACGCTTTTGGTAACGATTATCAATATTATTGGTTCGTA
TTATCTTCAATCAATCATTGATACCTATGTTCCTAGTGTGATGAAGAATACACTAGGTATTATTTCCGTAGGTTTGGTTA
TTGTCTATGCCCTTCAACAAGTGATCTCATATGCGCAAGAGTATTTATTGCTGATATTAGGGCAACGTTTATCTATTGAT
GTAATTCTTTCTTATATCAAACATATTTTCAACCTTCCTATGTCTTTTTTCGCGACGAGAAGGACCGGGGAAATTGTTTC
TCGTTTTAATGATGCTAATTCAATCATTGATGCTTTAGCAAGTACAATTTTATCTATTTTCCTTGATGTTTCTGTCATTG
TAATTATATCTCTTGTTCTTTTTTCGCAGAATGTAAATCTATTTGTTATCAGTTTGCTTGCTCTGCCTATCTATGCAGTG
ATTATCTTTGCCTTCATGAAGCCATTTGAACGGATGAATCAAGAGACAATGGAAGCAAATTCAATCATGTCATCTTCTAT
TATTGAAGATATAAACGGTATTGAGACTATTAAATCATTAACTAGCGAAAAGATAAGATACCAAAAAATAGATAAAGAAT
TTGTAGCTTATCTTAAGAAATCTTTCAACTATAGTAGGGCAGAAAGCCAACAACGAGCATTGAAAAAAGTAGCTCAGCTT
ATCCTAAACGTGAGCATACTCTGGATAGGAGCCAATCTGGTTATGGACGGAAAAATGAGTTTAGGTCAACTGATTACCTA
TAACTCTCTCCTAATCTACTTTACAAATCCTCTGGAGAATATTATCAATCTTCAAACGAAACTTCAAACCGCTCAAGTCG
CTAATAATCGATTGAATGAGGTATATCTAGTTGAATCCGAGTTCTCTGAAAAGAAGAATGTTCAAGACTTATCTTTGACC
TCTGGTGACATAAAATTCAATGATGTTAGCTATCGATATGGATATGGAAAAGATGTTTTATCAGAAATAAATTTGCATAT
TAAACGAGGAAGCAAGGTTGCTTTTGTTGGGATTTCAGGTTCTGGAAAAACGACTTTAGCTAAGATGATTGTCAGTTTCT
TTGAACTAAGCAAAGGCGAAATATCATTAAATAATGTGAATCTAAATCAAATTGACAAACATGCTCTTCGCCAGCACATT
AACTATCTTCCTCAACAACCTTACGTATTTAATGGGACAATCCTTGAGAATTTACTTCTTGGAGCACGTGAAGGGACGAC
TCAAGAAGACATTATGAAGGCAGTAGAATTGGCTGAAATCAAGTCTGATATTGAACGTATGCCTTTGAATTATCAAACAG
AGTTAACCTCAGATGGTGCAGGGATTTCTGGAGGTCAACGTCAACGTATTGCCTTAGCAAGGGCATTATTGACAGATTCT
CCTGTTTTGATATTAGACGAAGCTACAAGTAACTTGGATATTTTGACTGAGAAGCGAATTGTTGATAACCTGATGGCTTT
AGATAAAACCTTGATATTTATTGCTCACCGTTTAACTATTGCAGAGCGTACAGAGCATGTCGTCGTTTTGGATAAAGGAA
AGATCATAGAGCAAGGAACACACAGAGACCTTGTTTCTCAGAATGGCTTTTATGCTCACTTGGTCAATAGTTAG

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (6-142)

• ABC transporter (ABC_tran) (500-650)

• ABC transporter transmembrane region (ABC_membrane) (169-438)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	82.008	100	0.82
comA	Streptococcus mitis SK321	81.59	100	0.816
comA	Streptococcus pneumoniae Rx1	81.59	100	0.816
comA	Streptococcus pneumoniae D39	81.59	100	0.816
comA	Streptococcus pneumoniae R6	81.59	100	0.816
comA	Streptococcus pneumoniae TIGR4	81.311	100	0.813
comA	Streptococcus gordonii str. Challis substr. CH1	78.522	100	0.785
comA/nlmT	Streptococcus mutans UA159	62.762	100	0.628