Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | HWI58_RS00290 | Genome accession | NZ_CP064473 |
| Coordinates | 65521..67149 (-) | Length | 542 a.a. |
| NCBI ID | WP_001631035.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain UMCG386 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 34928..82117 | 65521..67149 | within | 0 |
| SCCmec | 65521..105851 | 65521..67149 | within | 0 |
Gene organization within MGE regions
Location: 34928..105851
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI58_RS00150 (HWI58_00150) | - | 35839..36408 (-) | 570 | WP_408021147.1 | TetR/AcrR family transcriptional regulator | - |
| HWI58_RS00155 (HWI58_00155) | - | 36758..37702 (-) | 945 | WP_002484621.1 | glycine betaine ABC transporter substrate-binding protein | - |
| HWI58_RS00160 (HWI58_00160) | - | 37726..40407 (-) | 2682 | WP_408021148.1 | MMPL family transporter | - |
| HWI58_RS00165 (HWI58_00165) | - | 40783..41136 (+) | 354 | WP_002487778.1 | hypothetical protein | - |
| HWI58_RS00170 (HWI58_00170) | - | 41381..42235 (-) | 855 | WP_223297891.1 | sensor histidine kinase KdpD | - |
| HWI58_RS00175 (HWI58_00175) | - | 42326..43081 (-) | 756 | WP_002487777.1 | ABC transporter permease | - |
| HWI58_RS00180 (HWI58_00180) | - | 43074..43988 (-) | 915 | WP_002487779.1 | ATP-binding cassette domain-containing protein | - |
| HWI58_RS00185 (HWI58_00185) | - | 44079..44747 (-) | 669 | WP_002487782.1 | response regulator transcription factor | - |
| HWI58_RS00190 (HWI58_00190) | - | 45357..46775 (-) | 1419 | WP_012087795.1 | aspartate aminotransferase family protein | - |
| HWI58_RS00195 (HWI58_00195) | - | 46864..47076 (-) | 213 | WP_002498809.1 | DUF1958 domain-containing protein | - |
| HWI58_RS00200 (HWI58_00200) | - | 47722..47925 (+) | 204 | WP_408021149.1 | hypothetical protein | - |
| HWI58_RS00205 | - | 48233..49348 (-) | 1116 | WP_223297879.1 | HEPN domain-containing protein | - |
| HWI58_RS00210 (HWI58_00215) | - | 49473..49756 (+) | 284 | Protein_39 | type I restriction-modification system subunit M N-terminal domain-containing protein | - |
| HWI58_RS00215 (HWI58_00220) | - | 49975..50901 (-) | 927 | WP_012087799.1 | NAD-dependent epimerase/dehydratase family protein | - |
| HWI58_RS00220 | - | 50914..52395 (-) | 1482 | WP_064585175.1 | glycosyltransferase | - |
| HWI58_RS00225 | - | 52448..52570 (-) | 123 | WP_257473759.1 | hypothetical protein | - |
| HWI58_RS00230 (HWI58_00230) | - | 53280..55547 (+) | 2268 | WP_012102514.1 | CDP-glycerol:glycerophosphate glycerophosphotransferase | - |
| HWI58_RS00235 (HWI58_00235) | - | 55904..56658 (+) | 755 | Protein_44 | transposase | - |
| HWI58_RS00240 (HWI58_00240) | - | 56733..59606 (-) | 2874 | WP_408021151.1 | CDP-glycerol glycerophosphotransferase family protein | - |
| HWI58_RS00245 (HWI58_00245) | galU | 59732..60497 (-) | 766 | Protein_46 | UTP--glucose-1-phosphate uridylyltransferase GalU | - |
| HWI58_RS00250 (HWI58_00250) | - | 60914..61045 (-) | 132 | WP_257473760.1 | hypothetical protein | - |
| HWI58_RS00255 | - | 61171..61286 (+) | 116 | Protein_48 | type I restriction enzyme endonuclease domain-containing protein | - |
| HWI58_RS00260 (HWI58_00255) | - | 61342..61773 (-) | 432 | WP_408021152.1 | hypothetical protein | - |
| HWI58_RS00265 (HWI58_00260) | - | 61823..62995 (-) | 1173 | WP_000195429.1 | IS256-like element IS256 family transposase | - |
| HWI58_RS00270 (HWI58_00265) | - | 63178..63456 (-) | 279 | WP_012086594.1 | hypothetical protein | - |
| HWI58_RS00275 (HWI58_00270) | - | 63754..64257 (-) | 504 | WP_012086592.1 | DUF1643 domain-containing protein | - |
| HWI58_RS00280 (HWI58_00275) | - | 64272..64583 (-) | 312 | WP_000700851.1 | DUF960 family protein | - |
| HWI58_RS00285 (HWI58_00280) | - | 64670..65020 (-) | 351 | WP_000849672.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI58_RS00290 (HWI58_00285) | ccrB | 65521..67149 (-) | 1629 | WP_001631035.1 | cassette chromosome recombinase CcrB | Machinery gene |
| HWI58_RS00295 (HWI58_00290) | ccrA | 67146..68507 (-) | 1362 | WP_001631036.1 | cassette chromosome recombinase CcrA | Machinery gene |
| HWI58_RS00300 (HWI58_00295) | - | 68694..69323 (-) | 630 | Protein_57 | hypothetical protein | - |
| HWI58_RS00305 (HWI58_00300) | - | 69332..69670 (+) | 339 | Protein_58 | recombinase family protein | - |
| HWI58_RS00310 (HWI58_00305) | - | 69782..70141 (-) | 360 | WP_001631039.1 | hypothetical protein | - |
| HWI58_RS00315 (HWI58_00310) | - | 70348..70674 (+) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| HWI58_RS00320 (HWI58_00315) | - | 71004..72929 (+) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| HWI58_RS00325 (HWI58_00320) | - | 74155..75411 (+) | 1257 | WP_000566670.1 | MrcB family domain-containing protein | - |
| HWI58_RS00330 (HWI58_00325) | - | 75826..76065 (+) | 240 | WP_001282728.1 | hypothetical protein | - |
| HWI58_RS00335 (HWI58_00330) | - | 76097..76771 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| HWI58_RS00340 (HWI58_00335) | - | 76862..77845 (-) | 984 | Protein_65 | protein rep | - |
| HWI58_RS00345 (HWI58_00340) | mobV | 78090..79352 (-) | 1263 | WP_000119405.1 | MobV family relaxase | - |
| HWI58_RS00350 (HWI58_00345) | bleO | 79859..80263 (-) | 405 | WP_001242578.1 | bleomycin binding protein | - |
| HWI58_RS00355 (HWI58_00350) | aadD1 | 80480..81250 (-) | 771 | WP_001795128.1 | aminoglycoside O-nucleotidyltransferase ANT(4')-Ia | - |
| HWI58_RS00360 (HWI58_00355) | - | 81443..82117 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| HWI58_RS00365 (HWI58_00360) | - | 82153..82542 (+) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| HWI58_RS00370 (HWI58_00365) | - | 83379..84122 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| HWI58_RS00375 (HWI58_00370) | - | 84219..84647 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| HWI58_RS00380 (HWI58_00375) | mecA | 84693..86702 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| HWI58_RS00385 (HWI58_00380) | mecR1 | 86799..88556 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| HWI58_RS00390 (HWI58_00385) | mecI | 88556..88927 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| HWI58_RS00395 (HWI58_00390) | psm-mec | 89012..89080 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| HWI58_RS00400 (HWI58_00395) | - | 89414..90544 (+) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| HWI58_RS00405 (HWI58_00400) | cstB | 90658..91992 (-) | 1335 | Protein_78 | persulfide dioxygenase-sulfurtransferase CstB | - |
| HWI58_RS00410 (HWI58_00405) | - | 92025..93089 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| HWI58_RS00415 (HWI58_00410) | cstR | 93225..93485 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| HWI58_RS00420 (HWI58_00415) | - | 93485..94123 (+) | 639 | Protein_81 | sulfite exporter TauE/SafE family protein | - |
| HWI58_RS00425 (HWI58_00425) | - | 94397..95013 (-) | 617 | Protein_82 | CadD family cadmium resistance transporter | - |
| HWI58_RS00430 (HWI58_00430) | - | 95094..97508 (-) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| HWI58_RS00435 (HWI58_00435) | - | 97501..97866 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| HWI58_RS00440 (HWI58_00440) | - | 98104..98481 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| HWI58_RS00445 (HWI58_00445) | - | 98488..100380 (-) | 1893 | WP_002485298.1 | site-specific integrase | - |
| HWI58_RS00450 (HWI58_00450) | - | 100575..100898 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| HWI58_RS00455 (HWI58_00455) | - | 100891..101097 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| HWI58_RS00460 (HWI58_00460) | - | 101099..101620 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| HWI58_RS00465 (HWI58_00465) | - | 101639..101950 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| HWI58_RS00470 (HWI58_00470) | - | 102035..102385 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI58_RS00475 (HWI58_00475) | ccrB | 102856..104484 (-) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| HWI58_RS00480 (HWI58_00480) | ccrA | 104505..105851 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62474.71 Da Isoelectric Point: 9.6103
>NTDB_id=502182 HWI58_RS00290 WP_001631035.1 65521..67149(-) (ccrB) [Staphylococcus epidermidis strain UMCG386]
MKQLKKKRIGLYARVSTEMQTDGYSIQGQLNQLTEYCQFQGYEVVNEYTDRGISGKTMQRPELQRMLKDANEGKLDCIMV
YKTNRLARNTSDLLNIVEELYKINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNTIVENVYNGQRQRAIEGYYQGNL
PLGYDKVPDSKKELMINQHEANIVKYIFDSYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDRNLWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEKSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILSYQDELNQINNQIYQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTIIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLPSTSSLFLPQTLYITIE
MKQLKKKRIGLYARVSTEMQTDGYSIQGQLNQLTEYCQFQGYEVVNEYTDRGISGKTMQRPELQRMLKDANEGKLDCIMV
YKTNRLARNTSDLLNIVEELYKINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNTIVENVYNGQRQRAIEGYYQGNL
PLGYDKVPDSKKELMINQHEANIVKYIFDSYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDRNLWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEKSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILSYQDELNQINNQIYQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTIIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLPSTSSLFLPQTLYITIE
Nucleotide
Download Length: 1629 bp
>NTDB_id=502182 HWI58_RS00290 WP_001631035.1 65521..67149(-) (ccrB) [Staphylococcus epidermidis strain UMCG386]
ATGAAACAACTCAAAAAGAAACGTATTGGATTATATGCACGTGTATCGACTGAAATGCAAACGGATGGTTACAGTATTCA
AGGTCAATTGAATCAACTTACAGAGTATTGTCAATTTCAAGGCTATGAAGTCGTCAATGAATACACCGATCGTGGTATAT
CAGGTAAAACAATGCAACGTCCAGAATTACAACGTATGTTAAAAGATGCCAACGAAGGTAAATTAGATTGTATTATGGTC
TACAAAACAAATCGTTTAGCTAGAAATACCTCAGATTTGTTAAATATTGTCGAGGAATTGTATAAGATTAATGTCGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCCAGTTCAACAGGTAAATTGATGCTCCAAATTTTAGCCAGCTTCGCAGAAT
TTGAACGTAATACGATTGTAGAGAATGTCTACAATGGCCAAAGACAACGTGCTATTGAAGGTTATTATCAAGGTAATTTA
CCTCTAGGCTACGATAAAGTACCTGACAGTAAAAAAGAGCTCATGATCAATCAACATGAAGCGAATATTGTTAAATATAT
TTTTGATTCATACGCTAAAGGTCATGGTTATCGTAAGATTGCGAACGCATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCTTTTAGTATTTCGTCCATTACCTACATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCTGATGGTAAACATGCGCCTATTATTGA
TAGAAACCTATGGGATAAAGTACAGTTTAAACGTCAAGAGAGTCGCAAGAAACCACAAGTTCACGGCAAAGGAACAAACC
TACTGACTGGGATTGTAAAATGTCCGAAATGTGGTGCAGCAATGGCGGCAAGTAATACAACTAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTACTCATGTAGCAATTTTAGAAATAAAGGTTCAAAAGTTTGTTCTGCCAATAGCGTTAG
AGCAGATGTACTAGAAAAATATGTTATGGATCAGATATTGGAAATTATCAAAAGCAAAAAGGTATTGAAGCAATTGGTTG
AAAAGGTAAATGAAAAAAGTCAAATAGACGTCTCTTCTTTGAACCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCAAAAATGCATACATTAACGAAAACTATTGAAGACTCACCTGACTTAGATAGCGTATTAAAACCAACAATACT
TAGCTACCAAGATGAATTGAATCAAATAAATAATCAAATCTATCAACTAGAACAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCGAATGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAATCATCGATCGCATTGACATAAGAAAAGATGAGCATCATAAGAAGCAATTTTATGTTACGCTCAAGTT
AAATAATGATATAATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCCTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA
ATGAAACAACTCAAAAAGAAACGTATTGGATTATATGCACGTGTATCGACTGAAATGCAAACGGATGGTTACAGTATTCA
AGGTCAATTGAATCAACTTACAGAGTATTGTCAATTTCAAGGCTATGAAGTCGTCAATGAATACACCGATCGTGGTATAT
CAGGTAAAACAATGCAACGTCCAGAATTACAACGTATGTTAAAAGATGCCAACGAAGGTAAATTAGATTGTATTATGGTC
TACAAAACAAATCGTTTAGCTAGAAATACCTCAGATTTGTTAAATATTGTCGAGGAATTGTATAAGATTAATGTCGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCCAGTTCAACAGGTAAATTGATGCTCCAAATTTTAGCCAGCTTCGCAGAAT
TTGAACGTAATACGATTGTAGAGAATGTCTACAATGGCCAAAGACAACGTGCTATTGAAGGTTATTATCAAGGTAATTTA
CCTCTAGGCTACGATAAAGTACCTGACAGTAAAAAAGAGCTCATGATCAATCAACATGAAGCGAATATTGTTAAATATAT
TTTTGATTCATACGCTAAAGGTCATGGTTATCGTAAGATTGCGAACGCATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCTTTTAGTATTTCGTCCATTACCTACATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCTGATGGTAAACATGCGCCTATTATTGA
TAGAAACCTATGGGATAAAGTACAGTTTAAACGTCAAGAGAGTCGCAAGAAACCACAAGTTCACGGCAAAGGAACAAACC
TACTGACTGGGATTGTAAAATGTCCGAAATGTGGTGCAGCAATGGCGGCAAGTAATACAACTAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTACTCATGTAGCAATTTTAGAAATAAAGGTTCAAAAGTTTGTTCTGCCAATAGCGTTAG
AGCAGATGTACTAGAAAAATATGTTATGGATCAGATATTGGAAATTATCAAAAGCAAAAAGGTATTGAAGCAATTGGTTG
AAAAGGTAAATGAAAAAAGTCAAATAGACGTCTCTTCTTTGAACCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCAAAAATGCATACATTAACGAAAACTATTGAAGACTCACCTGACTTAGATAGCGTATTAAAACCAACAATACT
TAGCTACCAAGATGAATTGAATCAAATAAATAATCAAATCTATCAACTAGAACAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCGAATGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAATCATCGATCGCATTGACATAAGAAAAGATGAGCATCATAAGAAGCAATTTTATGTTACGCTCAAGTT
AAATAATGATATAATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCCTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
72.694 |
100 |
0.727 |