Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   SSUD12_RS00355 Genome accession   NC_017621
Coordinates   58692..59591 (+) Length   299 a.a.
NCBI ID   WP_014637279.1    Uniprot ID   G7SIV6
Organism   Streptococcus suis D12     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 13688..57962 58692..59591 flank 730
IS/Tn 59944..61146 58692..59591 flank 353


Gene organization within MGE regions


Location: 13688..61146
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SSUD12_RS12040 - 13688..14017 (+) 330 Protein_14 ATP-dependent metallopeptidase FtsH/Yme1/Tma family protein -
  SSUD12_RS12045 - 14231..14566 (+) 336 Protein_15 AAA family ATPase -
  SSUD12_RS11770 - 14511..15695 (+) 1185 WP_268741106.1 ATP-dependent metallopeptidase FtsH/Yme1/Tma family protein -
  SSUD12_RS00080 (SSUD12_0017) comX/sigX 16033..16503 (+) 471 WP_014637247.1 sigma-70 family RNA polymerase sigma factor Regulator
  SSUD12_RS00185 (SSUD12_0019) mreC 23522..24358 (+) 837 WP_014637248.1 rod shape-determining protein MreC -
  SSUD12_RS00190 (SSUD12_0020) mreD 24375..24863 (+) 489 WP_014637249.1 rod shape-determining protein MreD -
  SSUD12_RS00195 (SSUD12_0021) pcsB 24948..26204 (+) 1257 WP_014637250.1 peptidoglycan hydrolase PcsB -
  SSUD12_RS00200 (SSUD12_0022) - 26307..27275 (+) 969 WP_002935337.1 ribose-phosphate diphosphokinase -
  SSUD12_RS00205 (SSUD12_0023) - 27362..28540 (+) 1179 WP_014637251.1 pyridoxal phosphate-dependent aminotransferase -
  SSUD12_RS00210 (SSUD12_0024) recO 28527..29309 (+) 783 WP_014637252.1 DNA repair protein RecO -
  SSUD12_RS00215 (SSUD12_0025) plsX 29306..30313 (+) 1008 WP_014637253.1 phosphate acyltransferase PlsX -
  SSUD12_RS00220 (SSUD12_0026) - 30306..30554 (+) 249 WP_014637254.1 phosphopantetheine-binding protein -
  SSUD12_RS00225 (SSUD12_0027) purC 30672..31379 (+) 708 WP_014637255.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  SSUD12_RS00230 (SSUD12_0028) - 31392..35146 (+) 3755 Protein_27 phosphoribosylformylglycinamidine synthase -
  SSUD12_RS00235 (SSUD12_0030) purF 35149..36603 (+) 1455 WP_014637256.1 amidophosphoribosyltransferase -
  SSUD12_RS00240 (SSUD12_0031) purM 36660..37776 (+) 1117 Protein_29 phosphoribosylformylglycinamidine cyclo-ligase -
  SSUD12_RS00245 (SSUD12_0033) purN 37773..38333 (+) 561 WP_014637257.1 phosphoribosylglycinamide formyltransferase -
  SSUD12_RS00250 (SSUD12_0034) - 38326..38907 (+) 582 WP_014637258.1 hypothetical protein -
  SSUD12_RS00255 (SSUD12_0035) purH 38921..40468 (+) 1548 WP_014637259.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  SSUD12_RS00260 (SSUD12_0036) - 40534..41364 (+) 831 WP_041179240.1 DNA adenine methylase -
  SSUD12_RS00265 (SSUD12_0037) - 41354..42169 (+) 816 WP_029750015.1 DNA-methyltransferase -
  SSUD12_RS00270 (SSUD12_0038) - 42147..43073 (+) 927 WP_014637262.1 type II restriction endonuclease -
  SSUD12_RS00275 (SSUD12_0039) - 43073..43978 (+) 906 WP_014637263.1 type II restriction endonuclease -
  SSUD12_RS00280 (SSUD12_0040) purD 44098..45360 (+) 1263 WP_014637264.1 phosphoribosylamine--glycine ligase -
  SSUD12_RS00285 (SSUD12_0041) purE 45386..45874 (+) 489 WP_014637265.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  SSUD12_RS00290 (SSUD12_0042) purK 45861..46946 (+) 1086 WP_014637266.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  SSUD12_RS00295 (SSUD12_0043) - 46973..47908 (+) 936 WP_014637267.1 hypothetical protein -
  SSUD12_RS00300 - 47921..48505 (+) 585 WP_041179186.1 hypothetical protein -
  SSUD12_RS00305 (SSUD12_0044) purB 48502..49794 (+) 1293 WP_014637268.1 adenylosuccinate lyase -
  SSUD12_RS00310 (SSUD12_0046) - 50582..51310 (+) 729 WP_014637270.1 hypothetical protein -
  SSUD12_RS00315 (SSUD12_0047) - 51320..51898 (+) 579 WP_014637271.1 CPBP family intramembrane glutamic endopeptidase -
  SSUD12_RS00320 (SSUD12_0048) - 51913..52320 (+) 408 WP_014637272.1 Msa family membrane protein -
  SSUD12_RS00325 (SSUD12_0049) - 52334..53206 (+) 873 WP_014637273.1 ABC transporter ATP-binding protein -
  SSUD12_RS00330 (SSUD12_0050) - 53212..53982 (+) 771 WP_014637274.1 hypothetical protein -
  SSUD12_RS00335 (SSUD12_0051) - 53985..55697 (+) 1713 WP_014637275.1 ABC transporter ATP-binding protein -
  SSUD12_RS11655 (SSUD12_0052) - 55798..55971 (+) 174 WP_014637276.1 hypothetical protein -
  SSUD12_RS00340 (SSUD12_0053) ruvB 56215..57216 (+) 1002 WP_014637277.1 Holliday junction branch migration DNA helicase RuvB -
  SSUD12_RS00345 (SSUD12_0054) - 57216..57962 (+) 747 Protein_51 GNAT family N-acetyltransferase -
  SSUD12_RS00350 (SSUD12_0056) - 57964..58587 (+) 624 WP_014637278.1 HAD-IA family hydrolase -
  SSUD12_RS00355 (SSUD12_0057) comR 58692..59591 (+) 900 WP_014637279.1 helix-turn-helix domain-containing protein Regulator
  SSUD12_RS00360 (SSUD12_0058) - 59944..61146 (-) 1203 WP_014637280.1 IS110 family transposase -

Sequence

Protein


Download         Length: 299 a.a.        Molecular weight: 35233.01 Da        Isoelectric Point: 4.4737

>NTDB_id=49760 SSUD12_RS00355 WP_014637279.1 58692..59591(+) (comR) [Streptococcus suis D12]
MNDKEFGQRVRQLRETASLTREQFCDDELELSVRQLTRIEAGTSKPTFSKIQYIATRLGMGLYELMPDYVSLPERYSKLK
FDVLRTPTYGNEELVEKRDAIMTEIYDDYYDDLPEEEKIAIDSIQSRIDTLESGTAGFGKEILEDYFEQIFRKQKYEVND
LLIIRLQLEYVRLSSSDSEIFGQFLKIIEYLHGQIDIINSSDLFVLRDTLLSCVNILGSKKYYEPIPKIFDSVDKIIQST
QDFQKKPIVSVLKWKYALFVDKDRDEAEKHYLDAVLFAKLIENRELEQKIEEDWRVDNQ

Nucleotide


Download         Length: 900 bp        

>NTDB_id=49760 SSUD12_RS00355 WP_014637279.1 58692..59591(+) (comR) [Streptococcus suis D12]
ATGAACGATAAGGAATTTGGACAACGTGTACGTCAACTTCGAGAAACCGCTAGTCTGACACGTGAACAGTTTTGCGATGA
CGAACTTGAGCTCTCCGTCCGCCAATTAACCCGTATCGAAGCAGGTACTTCTAAGCCGACTTTTTCAAAAATCCAATATA
TCGCAACCCGCTTAGGCATGGGGCTCTATGAGCTTATGCCTGATTATGTATCCTTGCCAGAAAGATACTCCAAGCTGAAA
TTTGATGTCCTCCGTACACCGACTTATGGTAATGAGGAATTAGTTGAAAAACGTGATGCTATCATGACGGAAATCTATGA
TGATTACTACGACGACTTGCCTGAGGAGGAGAAAATAGCGATTGATTCCATTCAATCCCGAATTGATACCTTAGAGTCAG
GGACAGCAGGCTTTGGAAAAGAGATACTGGAAGATTACTTTGAACAAATTTTCCGAAAACAAAAGTACGAAGTGAATGAT
TTGCTGATTATTAGGCTCCAGCTTGAATACGTTAGATTGTCCAGTAGTGACTCAGAAATATTTGGACAGTTTTTGAAAAT
TATAGAATATTTACATGGACAAATTGATATTATCAATTCAAGTGATTTATTTGTTCTAAGAGATACATTGTTATCTTGTG
TAAACATTTTGGGAAGTAAAAAATATTACGAACCAATACCAAAGATATTTGACAGTGTAGATAAGATTATACAGTCGACA
CAAGATTTTCAGAAAAAGCCCATTGTTAGTGTATTAAAATGGAAATATGCACTTTTTGTGGATAAGGATCGGGATGAGGC
TGAAAAGCATTATCTAGATGCGGTGCTATTTGCAAAATTGATAGAAAATAGAGAGTTAGAACAAAAGATTGAAGAAGATT
GGAGAGTTGACAATCAATAA

Domains

Predicted by InterproScan.

Helix-turn-helix domain (HTH_31)

(5-60)

ComR tetratricopeptide (ComR_TPR)

(73-294)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB G7SIV6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus suis P1/7

93.98

100

0.94
  comR Streptococcus suis 05ZYH33

93.98

100

0.94
  comR Streptococcus suis D9

59.801

100

0.602
  comR Streptococcus mutans UA159

45.151

100

0.452
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

37.801

97.324

0.368
  comR Streptococcus pyogenes MGAS315

37.037

99.331

0.368

Multiple sequence alignment