Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   IM723_RS05580 Genome accession   NZ_CP063275
Coordinates   1068645..1069352 (-) Length   235 a.a.
NCBI ID   WP_173940375.1    Uniprot ID   A0A2H4K9R7
Organism   Streptococcus thermophilus strain DMST-H2     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1063645..1074352
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IM723_RS05555 yidA 1063996..1064805 (+) 810 WP_011226081.1 sugar-phosphatase -
  IM723_RS05560 - 1064807..1066021 (+) 1215 WP_211836787.1 aminoacyltransferase -
  IM723_RS05565 - 1066073..1066434 (-) 362 Protein_1046 YbaN family protein -
  IM723_RS05570 vicX 1066494..1067306 (-) 813 WP_011681204.1 MBL fold metallo-hydrolase Regulator
  IM723_RS05575 vicK 1067312..1068652 (-) 1341 WP_011227273.1 cell wall metabolism sensor histidine kinase VicK Regulator
  IM723_RS05580 vicR 1068645..1069352 (-) 708 WP_173940375.1 response regulator YycF Regulator
  IM723_RS05585 - 1069879..1070646 (+) 768 WP_022096757.1 amino acid ABC transporter ATP-binding protein -
  IM723_RS05590 - 1070658..1071491 (+) 834 WP_002953142.1 transporter substrate-binding domain-containing protein -
  IM723_RS05595 - 1071509..1072207 (+) 699 WP_002953144.1 amino acid ABC transporter permease -
  IM723_RS05600 - 1072219..1072869 (+) 651 WP_211836788.1 amino acid ABC transporter permease -
  IM723_RS05605 endA 1072940..1073821 (-) 882 WP_011681210.1 DNA/RNA non-specific endonuclease Machinery gene
  IM723_RS05610 - 1073883..1074071 (-) 189 WP_011226090.1 DNA-directed RNA polymerase subunit beta -

Sequence

Protein


Download         Length: 235 a.a.        Molecular weight: 27087.04 Da        Isoelectric Point: 5.0130

>NTDB_id=494166 IM723_RS05580 WP_173940375.1 1068645..1069352(-) (vicR) [Streptococcus thermophilus strain DMST-H2]
MKKILVVDDERPISDIIKFNLTKEGYEVVTAFDGREALEQFEAKKPDLVILDLMLPELDGLEIAKEIRKTSHTPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARIKAHLRRTETIETAVEESSNSGKQEISIGELIIVPDAFVAKKRGNEVEL
THREFELLFHLATHMGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKNYD

Nucleotide


Download         Length: 708 bp        

>NTDB_id=494166 IM723_RS05580 WP_173940375.1 1068645..1069352(-) (vicR) [Streptococcus thermophilus strain DMST-H2]
ATGAAAAAAATTCTAGTTGTTGATGATGAAAGACCAATCTCCGATATCATCAAGTTTAACCTTACTAAGGAGGGTTATGA
AGTGGTTACGGCCTTTGATGGGCGAGAAGCTTTGGAACAATTTGAAGCTAAAAAACCAGACTTGGTTATTCTGGACTTGA
TGTTGCCTGAACTGGATGGTTTGGAAATTGCCAAGGAAATCCGTAAAACGAGCCACACACCGATTATCATGCTTTCAGCT
AAAGATAGTGAGTTTGATAAGGTTATCGGATTAGAAATTGGGGCAGACGACTATGTGACTAAGCCATTTTCTAACCGTGA
ATTGTTGGCACGTATTAAAGCCCACTTGCGTCGTACAGAAACGATTGAAACTGCAGTAGAAGAGAGCTCTAACTCTGGCA
AACAAGAAATTTCAATTGGTGAGTTGATTATTGTTCCGGATGCCTTTGTTGCTAAAAAACGTGGAAACGAAGTTGAGTTG
ACCCATCGTGAATTTGAGTTACTCTTCCATTTGGCAACTCATATGGGACAAGTTATGACGCGTGAACATTTGCTTGAAAC
CGTTTGGGGCTATGACTATTTTGGGGATGTTCGTACTGTGGACGTAACGATTCGTCGTCTGCGTGAAAAAATTGAAGATA
CACCTAGCCGTCCTGAATATATCTTGACGCGTCGTGGTGTCGGTTATTACATGAAGAATTATGACTAG

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(155-230)

Response regulator receiver domain (Response_reg)

(4-113)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2H4K9R7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

85.106

100

0.851
  micA Streptococcus pneumoniae Cp1015

79.828

99.149

0.791
  covR Lactococcus lactis subsp. lactis strain DGCC12653

45.455

98.298

0.447
  covR Streptococcus salivarius strain HSISS4

44.872

99.574

0.447
  scnR Streptococcus mutans UA159

38.136

100

0.383