Detailed information NTG0049157

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: INV104_RS04790
• Genome accession: NC_017591
• Coordinates: 908689..909339 (+)
• Length: 216 a.a.
• NCBI ID: WP_000387352.1
• Uniprot ID: A0A4J1SCX2
• Organism: Streptococcus pneumoniae INV104
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 903689..914339

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
INV104_RS04755 (INV104_08100)	-	904185..904400 (+)	216	WP_001232078.1	YozE family protein	-
INV104_RS04760 (INV104_08110)	-	904486..905454 (+)	969	WP_000658181.1	PhoH family protein	-
INV104_RS04765 (INV104_08120)	-	905634..906134 (+)	501	WP_000566988.1	GNAT family N-acetyltransferase	-
INV104_RS04770 (INV104_08130)	-	906137..906463 (+)	327	Protein_927	TfoX/Sxy family protein	-
INV104_RS11995 (INV104_08140)	ald	906764..907875 (-)	1112	Protein_928	alanine dehydrogenase	-
INV104_RS04785 (INV104_08150)	-	908052..908621 (+)	570	WP_000443745.1	GNAT family N-acetyltransferase	-
INV104_RS04790 (INV104_08160)	comEA/celA/cilE	908689..909339 (+)	651	WP_000387352.1	helix-hairpin-helix domain-containing protein	Machinery gene
INV104_RS04795 (INV104_08170)	comEC/celB	909323..911563 (+)	2241	WP_000942422.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
INV104_RS04800	-	911743..911931 (+)	189	WP_010976492.1	hypothetical protein	-
INV104_RS04805 (INV104_08180)	-	911963..912550 (+)	588	WP_000933542.1	ATP-binding cassette domain-containing protein	-
INV104_RS04810 (INV104_08190)	-	912554..913729 (+)	1176	WP_000655940.1	hypothetical protein	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23085.30 Da
• Isoelectric Point: 6.0661

>NTDB_id=49157 INV104_RS04790 WP_000387352.1 908689..909339(+) (comEA/celA/cilE) [Streptococcus pneumoniae INV104]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTSVKETNLQAEVAAVSKDSSTGKEVNKEEKEEPVEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=49157 INV104_RS04790 WP_000387352.1 908689..909339(+) (comEA/celA/cilE) [Streptococcus pneumoniae INV104]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACATCTGTCAAAGAGACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGACT
CATCGACCGGAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCAGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAACAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATTGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGCCAAGACCATAGAAAAACTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• Helix-hairpin-helix motif (HHH_3) (151-214)

• SLBB domain (SLBB) (76-126)

3D structure

• AlphaFold DB: A0A4J1SCX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.685	100	0.977
comEA/celA/cilE	Streptococcus pneumoniae Rx1	95.833	100	0.958
comEA/celA/cilE	Streptococcus pneumoniae D39	95.833	100	0.958
comEA/celA/cilE	Streptococcus pneumoniae R6	95.833	100	0.958
comEA/celA/cilE	Streptococcus mitis NCTC 12261	95.37	100	0.954
comEA/celA/cilE	Streptococcus mitis SK321	92.593	100	0.926
comEA	Lactococcus lactis subsp. cremoris KW2	44.053	100	0.463
comEA	Latilactobacillus sakei subsp. sakei 23K	34.335	100	0.37