Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   INV104_RS02595 Genome accession   NC_017591
Coordinates   501841..503994 (-) Length   717 a.a.
NCBI ID   WP_000205170.1    Uniprot ID   G3ECC8
Organism   Streptococcus pneumoniae INV104     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 496841..508994
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  INV104_RS02565 (INV104_04410) - 497173..497502 (-) 330 WP_000132572.1 hypothetical protein -
  INV104_RS02570 (INV104_04420) - 497779..498117 (+) 339 WP_000682133.1 LytTR family DNA-binding domain-containing protein -
  INV104_RS02575 (INV104_04430) comE/blpR 498122..498859 (+) 738 WP_001219141.1 response regulator transcription factor Regulator
  INV104_RS02580 (INV104_04440) - 498873..500213 (+) 1341 WP_001099891.1 sensor histidine kinase -
  INV104_RS02585 (INV104_04450) blpC 500284..500412 (-) 129 WP_000358815.1 quorum-sensing system pheromone BlpC -
  INV104_RS02590 (INV104_04460) - 500469..501830 (-) 1362 WP_001069076.1 bacteriocin secretion accessory protein -
  INV104_RS02595 (INV104_04470) comA/nlmT 501841..503994 (-) 2154 WP_000205170.1 peptide cleavage/export ABC transporter BlpA Regulator
  INV104_RS02600 blpI 504276..504473 (+) 198 WP_001093259.1 bacteriocin-like peptide BlpI -
  INV104_RS02605 (INV104_04500) blpJ 504940..505209 (+) 270 WP_001093248.1 bacteriocin-like peptide BlpJ -
  INV104_RS02610 blpU 505278..505508 (+) 231 WP_000379964.1 bacteriocin-like peptide BlpU -
  INV104_RS11750 - 505511..505630 (+) 120 WP_001844187.1 PncF family bacteriocin immunity protein -
  INV104_RS11755 (INV104_04510) - 505929..506093 (+) 165 WP_000727118.1 hypothetical protein -
  INV104_RS02620 - 506090..506494 (+) 405 WP_000846570.1 hypothetical protein -
  INV104_RS11760 - 506697..507501 (+) 805 WP_128887636.1 IS5 family transposase -
  INV104_RS02635 blpM 507651..507905 (+) 255 WP_000379879.1 two-peptide bacteriocin subunit BlpM -
  INV104_RS02640 blpN 507921..508124 (+) 204 WP_001099492.1 two-peptide bacteriocin subunit BlpN -
  INV104_RS02645 cipB 508368..508517 (+) 150 WP_001818346.1 bacteriocin-like peptide BlpO Regulator
  INV104_RS02650 - 508621..508740 (+) 120 WP_000346296.1 PncF family bacteriocin immunity protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80795.81 Da        Isoelectric Point: 7.6798

>NTDB_id=49149 INV104_RS02595 WP_000205170.1 501841..503994(-) (comA/nlmT) [Streptococcus pneumoniae INV104]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLVIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYILQQVMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLISIPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQTSLKQGTKL
VLNILILWFGAQLVMSSKISIGQLITFNTLLSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSHFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHI
NYLPQQAYIFNGSILENLTLGGNHMISQEDILRACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSGLDVLTEKKVIDNLMSLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=49149 INV104_RS02595 WP_000205170.1 501841..503994(-) (comA/nlmT) [Streptococcus pneumoniae INV104]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGGCCTGTTCAAGCAGATAAAACTCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGGTTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCTTCCTTCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTTCTTA
TTATCTCCAAGGAATCTTAGATGAATACATCCCAAATCAGATGAAATCAACTTTAGGAATCATCTCAGTTGGTCTGGTTA
TCACCTATATCCTCCAACAAGTCATGAGCTTCTCCAGAGATTATCTCCTAACCGTTCTGAGCCAGAGATTAAGCATTGAT
GTGATTTTATCCTATATTCGCCATATTTTTGAACTTCCCATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCATTTC
ACGGTTCACAGATGCTAACTCTATTATAGATGCCTTGGCTTCTACCATTCTTTCTCTTTTCCTGGATGTTTCTATTCTGA
TTCTTGTAGGGGGCGTCTTACTGGCACAAAACCCTAATCTCTTCCTTCTTTCTCTTATTTCTATTCCTATATACATGTTC
ATCATCTTTTCTTTTATGAAGCCTTTCGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGCTCTGCCAT
TATCGAAGATATCAACGGGATTGAAACTATAAAGTCGCTCACGAGTGAAGAAAATCGCTATCAAAATATAGACAGCGAAT
TTGTAGATTATTTGGAAAAATCCTTTAAGCTCAGTAAATATTCTATTTTACAAACAAGTTTAAAGCAGGGAACAAAATTA
GTTCTGAATATCCTTATCCTATGGTTTGGCGCTCAATTAGTCATGTCGAGTAAAATTTCTATCGGTCAGCTGATTACCTT
TAACACACTTCTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTCCAAACCAAACTCCAATCTGCGAAGGTTG
CTAATAACCGTTTGAACGAAGTCTATCTAGTCGAATCTGAATTTCAAGTTCAAGAAAACCCTGTTCATTCACATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATTAATCTCACGAT
TAAACAAGGAGATAAGGTTAGCCTAGTTGGAGTTAGTGGTTCTGGTAAAACAACTTTAGCCAAAATGATTGTCAATTTCT
TTGAACCCTACAAAGGACATATTTCCATCAATCATCAGGATATTAAAAACATTGATAAAAAAGTCTTGCGCCGTCATATT
AATTACCTACCACAACAAGCCTATATCTTTAATGGCTCTATCTTGGAAAACTTAACTTTGGGCGGTAATCATATGATTAG
CCAAGAAGATATTCTAAGAGCTTGTGAATTAGCTGAAATTCGTCAAGACATTGAAAGAATGCCTATGGGCTATCAAACTC
AGCTCTCTGATGGAGCTGGTCTATCAGGAGGACAAAAGCAACGAATAGCCCTCGCTCGTGCTCTTTTAACTAAATCTCCT
GTTTTAATACTAGACGAAGCTACTAGCGGTCTTGATGTCTTGACTGAGAAAAAGGTTATAGATAATCTTATGTCTCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTCAGTATAGCCGAACGAACCAACCGTGTCATTGTTCTTGACCAGGGGA
AAATCATTGAAGTTGGTAGTCACCAAGAGTTAATGCAGGCGCAAGGTTTCTACCATCATCTATTCAATAAATAA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-649)

ABC transporter transmembrane region (ABC_membrane)

(169-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB G3ECC8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

71.888

99.721

0.717
  comA Streptococcus mitis NCTC 12261

66.62

99.442

0.662
  comA Streptococcus pneumoniae Rx1

66.059

99.442

0.657
  comA Streptococcus pneumoniae R6

66.059

99.442

0.657
  comA Streptococcus pneumoniae D39

66.059

99.442

0.657
  comA Streptococcus mitis SK321

66.059

99.442

0.657
  comA Streptococcus gordonii str. Challis substr. CH1

65.32

100

0.654
  comA Streptococcus pneumoniae TIGR4

65.778

99.442

0.654

Multiple sequence alignment