Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SESEC_RS08890 Genome accession   NC_017582
Coordinates   1873668..1874432 (-) Length   254 a.a.
NCBI ID   WP_014623472.1    Uniprot ID   -
Organism   Streptococcus equi subsp. zooepidemicus ATCC 35246     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1856804..1909958 1873668..1874432 within 0


Gene organization within MGE regions


Location: 1856804..1909958
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SESEC_RS08825 (SeseC_02257) amiE 1857052..1858122 (-) 1071 WP_012516279.1 ABC transporter ATP-binding protein Regulator
  SESEC_RS08830 (SeseC_02258) amiD 1858131..1859057 (-) 927 WP_014623462.1 oligopeptide ABC transporter permease OppC Regulator
  SESEC_RS08835 (SeseC_02259) amiC 1859057..1860556 (-) 1500 WP_014623463.1 ABC transporter permease Regulator
  SESEC_RS08840 (SeseC_02260) amiA3 1860620..1862596 (-) 1977 WP_014623464.1 peptide ABC transporter substrate-binding protein Regulator
  SESEC_RS08845 (SeseC_02261) pbp3 1862904..1864142 (+) 1239 WP_014623465.1 D-alanyl-D-alanine carboxypeptidase PBP3 -
  SESEC_RS08850 (SeseC_02262) pbp3 1864465..1865700 (+) 1236 WP_014623466.1 D-alanyl-D-alanine carboxypeptidase PBP3 -
  SESEC_RS08855 (SeseC_02265) - 1865784..1866965 (+) 1182 WP_038673980.1 D-alanyl-D-alanine carboxypeptidase family protein -
  SESEC_RS08860 (SeseC_02266) sufB 1867125..1868543 (-) 1419 WP_012516286.1 Fe-S cluster assembly protein SufB -
  SESEC_RS08865 (SeseC_02267) sufU 1868583..1869020 (-) 438 WP_038673978.1 Fe-S cluster assembly sulfur transfer protein SufU -
  SESEC_RS08870 (SeseC_02268) - 1869007..1870233 (-) 1227 WP_014623468.1 cysteine desulfurase -
  SESEC_RS08875 (SeseC_02269) sufD 1870260..1871522 (-) 1263 WP_014623469.1 Fe-S cluster assembly protein SufD -
  SESEC_RS08880 (SeseC_02270) sufC 1871613..1872383 (-) 771 WP_014623470.1 Fe-S cluster assembly ATPase SufC -
  SESEC_RS08885 (SeseC_02271) - 1872504..1873661 (-) 1158 WP_038674746.1 glycosyltransferase family 4 protein -
  SESEC_RS08890 (SeseC_02272) mecA 1873668..1874432 (-) 765 WP_014623472.1 adaptor protein MecA Regulator
  SESEC_RS08895 (SeseC_02273) - 1874552..1875391 (-) 840 WP_014623473.1 undecaprenyl-diphosphate phosphatase -
  SESEC_RS08900 (SeseC_02275) - 1875707..1877275 (+) 1569 WP_014623474.1 ABC transporter substrate-binding protein/permease -
  SESEC_RS08905 (SeseC_02277) - 1877268..1878008 (+) 741 WP_014623475.1 amino acid ABC transporter ATP-binding protein -
  SESEC_RS10605 - 1878335..1878451 (+) 117 WP_012677375.1 putative metal homeostasis protein -
  SESEC_RS08910 (SeseC_02279) - 1878966..1879856 (-) 891 WP_012677374.1 SPFH domain-containing protein -
  SESEC_RS08915 (SeseC_02280) - 1880120..1881784 (-) 1665 WP_014623477.1 DAK2 domain-containing protein -
  SESEC_RS08920 (SeseC_02281) - 1881784..1882149 (-) 366 WP_012516300.1 Asp23/Gls24 family envelope stress response protein -
  SESEC_RS08925 (SeseC_02282) rpmB 1882301..1882489 (-) 189 WP_002982870.1 50S ribosomal protein L28 -
  SESEC_RS08930 (SeseC_02283) - 1882935..1884236 (-) 1302 WP_014623479.1 ISLre2 family transposase -
  SESEC_RS08935 (SeseC_02284) - 1884386..1884685 (-) 300 WP_014623480.1 hypothetical protein -
  SESEC_RS08940 (SeseC_02285) - 1884697..1885947 (-) 1251 WP_014623481.1 site-specific DNA-methyltransferase -
  SESEC_RS08945 (SeseC_02287) - 1885959..1887602 (-) 1644 WP_038673973.1 helical hairpin domain-containing protein -
  SESEC_RS08950 (SeseC_02288) - 1887565..1887948 (-) 384 WP_014623483.1 plasmid mobilization protein -
  SESEC_RS08955 - 1887969..1888178 (-) 210 WP_154224854.1 hypothetical protein -
  SESEC_RS08960 (SeseC_02289) - 1888292..1888591 (-) 300 WP_014623484.1 hypothetical protein -
  SESEC_RS08965 (SeseC_02290) - 1888643..1891882 (-) 3240 WP_038673969.1 PBECR4 domain-containing protein -
  SESEC_RS08970 (SeseC_02291) - 1891921..1893966 (-) 2046 WP_038673967.1 VirD4-like conjugal transfer protein, CD1115 family -
  SESEC_RS08975 (SeseC_02292) - 1893966..1894457 (-) 492 WP_014623487.1 DUF3801 domain-containing protein -
  SESEC_RS08980 (SeseC_02293) - 1894479..1895261 (-) 783 WP_014623488.1 hypothetical protein -
  SESEC_RS08985 (SeseC_02294) - 1895261..1895533 (-) 273 WP_014623489.1 hypothetical protein -
  SESEC_RS08990 (SeseC_02295) - 1895555..1896157 (-) 603 WP_038673964.1 hypothetical protein -
  SESEC_RS08995 (SeseC_02296) - 1896181..1898877 (-) 2697 WP_014623491.1 phage tail tip lysozyme -
  SESEC_RS10695 (SeseC_02297) - 1898910..1899440 (+) 531 WP_154224853.1 hypothetical protein -
  SESEC_RS09010 (SeseC_02298) - 1899634..1901985 (-) 2352 WP_014623493.1 VirB4-like conjugal transfer ATPase, CD1110 family -
  SESEC_RS09015 (SeseC_02299) - 1901966..1902325 (-) 360 WP_037582122.1 hypothetical protein -
  SESEC_RS10970 (SeseC_02300) - 1902681..1902914 (-) 234 WP_014623495.1 hypothetical protein -
  SESEC_RS09025 (SeseC_02301) - 1903075..1903827 (-) 753 WP_014623496.1 hypothetical protein -
  SESEC_RS09030 (SeseC_02302) - 1903876..1904442 (-) 567 WP_014623497.1 hypothetical protein -
  SESEC_RS09035 (SeseC_02303) - 1904547..1904774 (-) 228 WP_000447009.1 hypothetical protein -
  SESEC_RS09040 (SeseC_02304) - 1905051..1908572 (-) 3522 WP_014623499.1 SspB-related isopeptide-forming adhesin -
  SESEC_RS09045 (SeseC_02305) - 1908637..1909275 (-) 639 WP_038673957.1 LPXTG cell wall anchor domain-containing protein -
  SESEC_RS09050 (SeseC_02306) - 1909290..1909589 (-) 300 WP_038673954.1 hypothetical protein -

Sequence

Protein


Download         Length: 254 a.a.        Molecular weight: 29332.18 Da        Isoelectric Point: 4.2602

>NTDB_id=49076 SESEC_RS08890 WP_014623472.1 1873668..1874432(-) (mecA) [Streptococcus equi subsp. zooepidemicus ATCC 35246]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYAVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSDL
NKDLNFEDLADLGDISQMTPEDFFRSLEQSMREKGDVNAHEKLEKIEEIMEDVVDATLAEQADNKEAAELEEPTEPLDYV
HYVLDFASVRDAVCFAKAIDFPIEASELYKGPRHYHMTILLDVQNKPAYFANVMYARLIEHARPGTKTRAYLQEHGCQLI
FDGAVEELQKIRLG

Nucleotide


Download         Length: 765 bp        

>NTDB_id=49076 SESEC_RS08890 WP_014623472.1 1873668..1874432(-) (mecA) [Streptococcus equi subsp. zooepidemicus ATCC 35246]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGGGGTATGGAACT
CAAGGACTTCTTGATCCCTCAAGAAAAGACAGAGGAGTTCTTTTATGCTGTTATGGACGAGTTGGACCTTCCGGACAATT
TTAAGGACAGTGGTATGCTTAGCTTTCGAGTGACCCCAAGAAAGGATCGCTTAGATGTTTTTGTGACCAAGTCAGACCTC
AATAAGGACCTTAATTTTGAGGATTTGGCAGACCTAGGTGATATTTCTCAAATGACTCCAGAGGATTTTTTCAGGAGCTT
GGAGCAGTCTATGCGTGAAAAGGGTGATGTTAATGCCCATGAAAAGCTCGAAAAAATTGAGGAGATCATGGAGGACGTGG
TTGATGCTACCTTGGCTGAGCAAGCAGATAATAAGGAAGCTGCTGAGCTTGAAGAGCCGACAGAGCCACTTGATTACGTT
CACTATGTTCTTGATTTTGCTTCTGTGCGAGACGCTGTTTGCTTTGCTAAGGCGATTGATTTTCCGATCGAGGCTTCTGA
ATTGTATAAGGGTCCTCGTCATTATCACATGACGATTTTACTTGATGTGCAAAACAAGCCTGCCTACTTTGCCAATGTGA
TGTATGCCAGATTGATTGAGCATGCTAGACCTGGTACAAAAACAAGAGCTTATTTGCAGGAGCATGGTTGTCAGCTCATT
TTTGATGGTGCTGTTGAGGAGCTGCAAAAAATCAGGTTGGGGTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.745

98.819

0.63
  mecA Streptococcus thermophilus LMD-9

56.471

100

0.567
  mecA Streptococcus thermophilus LMG 18311

55.686

100

0.559
  mecA Streptococcus pneumoniae TIGR4

48.031

100

0.48
  mecA Streptococcus pneumoniae Rx1

47.638

100

0.476
  mecA Streptococcus pneumoniae D39

47.638

100

0.476
  mecA Streptococcus pneumoniae R6

47.638

100

0.476

Multiple sequence alignment