Detailed information NTG0049052

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: SESEC_RS04835
• Genome accession: NC_017582
• Coordinates: 1020917..1021591 (+)
• Length: 224 a.a.
• NCBI ID: WP_012515548.1
• Uniprot ID: B4U2R0
• Organism: Streptococcus equi subsp. zooepidemicus ATCC 35246
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1015917..1026591

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SESEC_RS04820 (SeseC_01208)	pstB	1016246..1017004 (+)	759	WP_038674325.1	phosphate ABC transporter ATP-binding protein PstB	-
SESEC_RS04825 (SeseC_01209)	phoU	1017075..1017728 (+)	654	WP_012678018.1	phosphate signaling complex protein PhoU	-
SESEC_RS04830 (SeseC_01210)	-	1017962..1020499 (+)	2538	WP_014622811.1	M1 family metallopeptidase	-
SESEC_RS04835 (SeseC_01211)	ciaR	1020917..1021591 (+)	675	WP_012515548.1	response regulator transcription factor	Regulator
SESEC_RS04840 (SeseC_01212)	ciaH	1021584..1022894 (+)	1311	WP_014622812.1	sensor histidine kinase	Regulator
SESEC_RS04845 (SeseC_01214)	-	1023278..1023712 (+)	435	WP_012678015.1	hypothetical protein	-
SESEC_RS10735 (SeseC_01215)	-	1023794..1023970 (+)	177	WP_014622814.1	hypothetical protein	-
SESEC_RS04850 (SeseC_01216)	-	1023986..1024393 (+)	408	WP_014622815.1	hypothetical protein	-
SESEC_RS04855 (SeseC_01217)	-	1024403..1024693 (+)	291	WP_014622816.1	hypothetical protein	-
SESEC_RS04860 (SeseC_01218)	-	1024617..1025000 (+)	384	WP_038674323.1	hypothetical protein	-
SESEC_RS04865 (SeseC_01219)	-	1025002..1025253 (+)	252	WP_014622818.1	hypothetical protein	-
SESEC_RS04870 (SeseC_01220)	-	1025269..1025688 (+)	420	WP_014622819.1	hypothetical protein	-
SESEC_RS04875 (SeseC_01221)	-	1025858..1026184 (+)	327	WP_014622820.1	hypothetical protein	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25541.52 Da
• Isoelectric Point: 4.5644

>NTDB_id=49052 SESEC_RS04835 WP_012515548.1 1020917..1021591(+) (ciaR) [Streptococcus equi subsp. zooepidemicus ATCC 35246]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKDGFQVLKALREKDIKIPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRVGKFNDKSLKFGNLTVDTTRKEVQVNGQAIELLGKELDLLIY
ILQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTDFVNHLQTLRSVGYILKANE

Nucleotide

• Length: 675 bp

>NTDB_id=49052 SESEC_RS04835 WP_012515548.1 1020917..1021591(+) (ciaR) [Streptococcus equi subsp. zooepidemicus ATCC 35246]
ATGATAAAACTATTATTAGTAGAAGACGATTTAAGCTTATCAAATTCTATCTTTGATTTTTTAGATGACTTTGCTGATGT
GACGCAGGTTTTTGATGGTGACGAAGGACTCTATGAGGCAGAAAGCGGTATTTATGATTTGATTCTGTTAGATTTGATGC
TGCCTGAAAAGGATGGCTTTCAAGTGTTAAAAGCCTTACGTGAAAAAGACATCAAAATTCCCGTCTTGATCATGACTGCC
AAAGAAAGCATCGATGACAAGGGGCATGGCTTTGAGCTTGGTGCTGATGACTATTTAACTAAGCCCTTTTACCTAGAAGA
ATTAAAAATGCGGATTCAGGCCTTGCTTAAGCGTGTAGGAAAGTTTAATGACAAGAGCCTTAAATTTGGCAACTTGACTG
TAGATACTACCCGTAAAGAGGTACAGGTCAATGGGCAGGCCATAGAGCTATTAGGCAAGGAGCTTGATTTACTAATCTAT
ATCCTTCAAAATCAAAATGTTATTTTGCCAAAATCACAAATTTTTGATCGTATCTGGGGCTTTGATAGTGATACCACTAT
CTCTGTTGTAGAGGTCTATGTCTCTAAAATTCGTAAGAAGCTTAAGGGGACAGACTTTGTTAATCATCTTCAAACCTTGA
GAAGTGTAGGATATATCTTAAAAGCTAATGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: B4U2R0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	84.615	98.661	0.835
ciaR	Streptococcus pneumoniae Rx1	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae D39	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae R6	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae TIGR4	80.543	98.661	0.795
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.428	100	0.393
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362