Detailed information NTG0048148

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SPN034183_RS02655
• Genome accession: NC_021028
• Coordinates: 489216..489953 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219127.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae SPN034183
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 484216..494953

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPN034183_RS12165	-	485192..485386 (-)	195	WP_001808905.1	hypothetical protein	-
SPN034183_RS02625 (SPN034183_04830)	-	485548..485835 (-)	288	WP_000777760.1	hypothetical protein	-
SPN034183_RS02630 (SPN034183_04840)	-	485845..486255 (-)	411	WP_001278301.1	HIT family protein	-
SPN034183_RS02635 (SPN034183_04850)	pptA	486323..487054 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
SPN034183_RS02640 (SPN034183_04860)	pptB	487051..488100 (+)	1050	WP_000653752.1	ABC transporter permease	Regulator
SPN034183_RS02645 (SPN034183_04870)	-	488268..488597 (-)	330	WP_000132570.1	hypothetical protein	-
SPN034183_RS02650 (SPN034183_04880)	-	488873..489211 (+)	339	WP_000682119.1	LytTR family DNA-binding domain-containing protein	-
SPN034183_RS02655 (SPN034183_04890)	comE/blpR	489216..489953 (+)	738	WP_001219127.1	response regulator transcription factor	Regulator
SPN034183_RS02660 (SPN034183_04900)	-	489967..491307 (+)	1341	WP_001017622.1	sensor histidine kinase	-
SPN034183_RS02665 (SPN034183_04910)	blpC	491349..491504 (-)	156	WP_000358813.1	quorum-sensing system pheromone BlpC	-
SPN034183_RS02670 (SPN034183_04920)	-	491561..492922 (-)	1362	WP_015545695.1	bacteriocin secretion accessory protein	-
SPN034183_RS13405	comA/nlmT	492933..493436 (-)	504	WP_001808910.1	ATP-binding cassette domain-containing protein	Regulator
SPN034183_RS13410	comA/nlmT	493405..493845 (-)	441	WP_001808911.1	ATP-binding cassette domain-containing protein	Regulator
SPN034183_RS13415	comA/nlmT	493835..494560 (-)	726	WP_167750760.1	ABC transporter transmembrane domain-containing protein	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28683.81 Da
• Isoelectric Point: 6.0431

>NTDB_id=48148 SPN034183_RS02655 WP_001219127.1 489216..489953(+) (comE/blpR) [Streptococcus pneumoniae SPN034183]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPSLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=48148 SPN034183_RS02655 WP_001219127.1 489216..489953(+) (comE/blpR) [Streptococcus pneumoniae SPN034183]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTACATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTAGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCAGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.498	99.184	0.531
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384