Detailed information    

insolico Bioinformatically predicted

Overview

Name   dprA   Type   Machinery gene
Locus tag   IB935_RS04715 Genome accession   NZ_CP061134
Coordinates   932189..933025 (+) Length   278 a.a.
NCBI ID   WP_011017772.1    Uniprot ID   A0A660A2Q7
Organism   Streptococcus pyogenes strain BSAC_bs192 isolate Invasive disease     
Function   ssDNA binding; loading RecA onto ssDNA (predicted from homology)   
DNA processing

Genomic Context

Location: 927189..938025
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IB935_RS04685 (IB935_04685) - 927677..928111 (+) 435 WP_021299262.1 hypothetical protein -
  IB935_RS04690 (IB935_04690) - 928161..929072 (-) 912 WP_011528643.1 diacylglycerol/lipid kinase family protein -
  IB935_RS04695 (IB935_04695) trhA 929189..929839 (-) 651 WP_002984629.1 PAQR family membrane homeostasis protein TrhA -
  IB935_RS04700 (IB935_04700) - 929836..930276 (-) 441 WP_011017769.1 DUF1836 domain-containing protein -
  IB935_RS04705 (IB935_04705) ylqF 930495..931343 (+) 849 WP_011017770.1 ribosome biogenesis GTPase YlqF -
  IB935_RS04710 (IB935_04710) - 931333..932124 (+) 792 WP_011017771.1 ribonuclease HII -
  IB935_RS04715 (IB935_04715) dprA 932189..933025 (+) 837 WP_011017772.1 DNA-processing protein DprA Machinery gene
  IB935_RS04720 (IB935_04720) topA 933132..935261 (+) 2130 WP_011528644.1 type I DNA topoisomerase -
  IB935_RS04725 (IB935_04725) - 935337..936221 (-) 885 Protein_890 LysR family transcriptional regulator -
  IB935_RS04730 (IB935_04730) - 936234..936800 (+) 567 Protein_891 PTS sugar transporter subunit IIC -
  IB935_RS04735 (IB935_04735) - 936815..937807 (+) 993 WP_021299266.1 D-lactate dehydrogenase -

Sequence

Protein


Download         Length: 278 a.a.        Molecular weight: 31088.08 Da        Isoelectric Point: 9.0513

>NTDB_id=480987 IB935_RS04715 WP_011017772.1 932189..933025(+) (dprA) [Streptococcus pyogenes strain BSAC_bs192 isolate Invasive disease]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide


Download         Length: 837 bp        

>NTDB_id=480987 IB935_RS04715 WP_011017772.1 932189..933025(+) (dprA) [Streptococcus pyogenes strain BSAC_bs192 isolate Invasive disease]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

DNA recombination-mediator protein A (DNA_processg_A)

(68-269)

DNA processing protein A sterile alpha motif domain (SAM_DprA)

(1-62)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A660A2Q7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  dprA Streptococcus mutans UA159

67.626

100

0.676
  dprA/cilB/dalA Streptococcus pneumoniae Rx1

60.432

100

0.604
  dprA/cilB/dalA Streptococcus pneumoniae D39

60.432

100

0.604
  dprA/cilB/dalA Streptococcus pneumoniae R6

60.432

100

0.604
  dprA/cilB/dalA Streptococcus pneumoniae TIGR4

60.432

100

0.604
  dprA/cilB/dalA Streptococcus mitis SK321

60.432

100

0.604
  dprA/cilB/dalA Streptococcus mitis NCTC 12261

60.072

100

0.601
  dprA Lactococcus lactis subsp. cremoris KW2

57.194

100

0.572
  dprA Legionella pneumophila strain ERS1305867

42.857

85.612

0.367