Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   IBL27_RS04685 Genome accession   NZ_CP061071
Coordinates   930874..931548 (+) Length   224 a.a.
NCBI ID   WP_002264509.1    Uniprot ID   -
Organism   Streptococcus mutans B04Sm5     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 925874..936548
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IBL27_RS04665 (IBL27_04665) pstB 926126..926884 (+) 759 WP_002308191.1 phosphate ABC transporter ATP-binding protein PstB -
  IBL27_RS04670 (IBL27_04670) phoU 926916..927569 (+) 654 WP_002262211.1 phosphate signaling complex protein PhoU -
  IBL27_RS04675 (IBL27_04675) - 927610..930159 (+) 2550 WP_002288091.1 M1 family metallopeptidase -
  IBL27_RS04680 (IBL27_04680) ciaX 930560..930823 (+) 264 WP_002274220.1 three-component system regulator CiaX -
  IBL27_RS04685 (IBL27_04685) ciaR 930874..931548 (+) 675 WP_002264509.1 three-component system response regulator CiaR Regulator
  IBL27_RS04690 (IBL27_04690) ciaH 931538..932845 (+) 1308 WP_002264510.1 three-component system sensor histidine kinase CiaH Regulator
  IBL27_RS04695 (IBL27_04695) rpsT 932934..933188 (-) 255 WP_019321238.1 30S ribosomal protein S20 -
  IBL27_RS04700 (IBL27_04700) coaA 933242..934162 (-) 921 WP_002265491.1 type I pantothenate kinase -
  IBL27_RS04705 (IBL27_04705) - 934258..934854 (+) 597 WP_002308185.1 class I SAM-dependent methyltransferase -
  IBL27_RS04710 (IBL27_04710) - 934963..936240 (+) 1278 WP_002308182.1 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25417.19 Da        Isoelectric Point: 4.3777

>NTDB_id=480248 IBL27_RS04685 WP_002264509.1 930874..931548(+) (ciaR) [Streptococcus mutans B04Sm5]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGAEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN

Nucleotide


Download         Length: 675 bp        

>NTDB_id=480248 IBL27_RS04685 WP_002264509.1 930874..931548(+) (ciaR) [Streptococcus mutans B04Sm5]
ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGT
CATGCAGGTTTTTGATGGTGCAGAAGGACTGTATGAAGCAGAGAGTGGCGTTTATGATTTGATTCTATTAGACTTAATGC
TTCCTGAAAAAAATGGCTTCCAAGTTTTAAAAGAACTGCGTGAAAAAGGGATAACGACACCTGTTTTGATTATGACAGCT
AAGGAAGGTTTGGATGACAAAGGACACGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTTTATCTTGAAGA
ATTAAAAATGCGTATTCAGGCCCTCCTCAAACGTTCAGGCAAATTCAACGAAAATAATCTGACTTACGGTGAGTTAACCG
TTGATACAGCAACTAATACAACAATGGTAAATGGAAAAGAAGTTGAACTGCTTGGCAAAGAGTTTGACTTATTAGTTTAT
TTCTTACAAAATCAAAATGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGCGATACGACAAT
TTCGGTTGTTGAAGTCTATGTTTCTAAAATAAGAAAGAAATTAAAAGACACCACATTTGGAAAGAATTTACAGACATTAC
GCAGTGTAGGATATATTTTGAAGGATGCTAATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

99.554

100

0.996
  ciaR Streptococcus pneumoniae Rx1

87.946

100

0.879
  ciaR Streptococcus pneumoniae D39

87.946

100

0.879
  ciaR Streptococcus pneumoniae R6

87.946

100

0.879
  ciaR Streptococcus pneumoniae TIGR4

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.611

100

0.379
  vicR Streptococcus mutans UA159

35.622

100

0.371