Detailed information    

insolico Bioinformatically predicted

Overview

Name   dprA   Type   Machinery gene
Locus tag   NMBM04240196_RS00720 Genome accession   NC_017515
Coordinates   130963..132156 (+) Length   397 a.a.
NCBI ID   WP_002226908.1    Uniprot ID   A0A121S8B3
Organism   Neisseria meningitidis M04-240196     
Function   ssDNA binding; loading RecA onto ssDNA (predicted from homology)   
DNA processing

Genomic Context

Location: 125963..137156
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NMBM04240196_RS00705 (NMBM04240196_0116) - 126883..127482 (+) 600 WP_002216221.1 DUF4390 domain-containing protein -
  NMBM04240196_RS00710 (NMBM04240196_0117) - 127482..129602 (+) 2121 WP_014581290.1 PAS domain-containing sensor histidine kinase -
  NMBM04240196_RS00715 (NMBM04240196_0118) - 129595..130872 (+) 1278 WP_014581291.1 sigma-54 dependent transcriptional regulator -
  NMBM04240196_RS00720 (NMBM04240196_0119) dprA 130963..132156 (+) 1194 WP_002226908.1 DNA-processing protein DprA Machinery gene
  NMBM04240196_RS00725 (NMBM04240196_0120) - 132182..132643 (+) 462 WP_002215351.1 DUF494 family protein -
  NMBM04240196_RS00730 (NMBM04240196_0121) topA 132715..135021 (+) 2307 WP_002221835.1 type I DNA topoisomerase -
  NMBM04240196_RS00735 (NMBM04240196_0122) - 135094..135789 (-) 696 WP_002216227.1 hypothetical protein -
  NMBM04240196_RS00740 (NMBM04240196_0123) - 135809..136360 (-) 552 WP_002221836.1 hypothetical protein -
  NMBM04240196_RS00745 (NMBM04240196_0124) - 136478..136855 (+) 378 WP_002233408.1 helix-turn-helix transcriptional regulator -

Sequence

Protein


Download         Length: 397 a.a.        Molecular weight: 42168.02 Da        Isoelectric Point: 5.2875

>NTDB_id=47988 NMBM04240196_RS00720 WP_002226908.1 130963..132156(+) (dprA) [Neisseria meningitidis M04-240196]
MTEDERFAWLQLAFTPYIGAESFLLLLRRFGSASNALSAPAEQVAPAVRHKQAAEAWRNAEKRASARQAAEAALEWEMRD
GCRLMLLQDEDFPEMLTQGLTAPPVLFLRGNVRLLHKPSAAIVGSRHATPQAMRIAKDFGKSLGGQNIPVVSGMASGIDT
AAHQGALEAEGGTIAVWGTGIDRIYPPSNKNLAYEIAEKGLIVSEFPIGTRPYAGNFPRRNRLIAALSQVTLVVEAALES
GSLITAGLAAEMGREVMAVPGSIDNPHSKGCHKLIKDGAKLTECLDDILNECPGLLQNTGASSYSINKDTSDTGSRAVQT
AYAPPPSPEGKMPSEGAACGTDPGGILDKMGFDPVHPDVLAEQLAMPAADLYAALLELELDGSVAAMPGGRYQRIRT

Nucleotide


Download         Length: 1194 bp        

>NTDB_id=47988 NMBM04240196_RS00720 WP_002226908.1 130963..132156(+) (dprA) [Neisseria meningitidis M04-240196]
ATGACAGAGGACGAACGTTTCGCGTGGCTGCAATTGGCGTTTACGCCCTATATCGGCGCGGAAAGCTTCCTGCTGCTGCT
GCGCCGTTTCGGCAGCGCGTCAAACGCCCTGTCCGCACCGGCGGAACAGGTCGCCCCGGCGGTGCGGCACAAGCAGGCGG
CCGAGGCTTGGCGCAATGCGGAAAAACGCGCCTCGGCGCGGCAGGCGGCAGAAGCGGCGTTGGAATGGGAAATGCGGGAC
GGATGCCGCCTGATGCTGCTTCAGGATGAAGATTTCCCCGAAATGCTGACGCAGGGGCTGACCGCGCCGCCGGTTTTGTT
TTTGCGCGGCAACGTGCGGCTGCTGCACAAGCCTTCCGCCGCCATCGTCGGCAGCCGCCATGCCACGCCGCAGGCGATGC
GGATTGCCAAAGATTTCGGCAAGTCGTTGGGCGGGCAAAATATCCCCGTTGTGTCGGGTATGGCTTCCGGTATCGATACT
GCCGCCCATCAGGGCGCACTGGAGGCAGAAGGCGGCACCATCGCCGTGTGGGGGACGGGTATAGACCGCATTTACCCGCC
GTCCAATAAAAACCTTGCCTATGAAATCGCCGAAAAAGGATTGATTGTCAGCGAGTTTCCCATCGGTACGCGCCCGTATG
CCGGCAACTTTCCGCGCCGCAACCGCCTGATTGCCGCGCTGTCGCAGGTTACGCTGGTGGTTGAAGCTGCGTTGGAATCC
GGTTCGCTGATTACCGCCGGCTTGGCGGCAGAAATGGGGCGCGAAGTGATGGCAGTACCCGGTTCGATAGACAATCCGCA
CAGCAAAGGCTGCCACAAACTGATTAAAGACGGCGCGAAACTGACGGAATGTTTGGACGACATCCTGAACGAATGCCCGG
GGCTATTGCAAAATACGGGTGCTTCGTCATATTCTATAAATAAGGATACGTCCGACACGGGCAGCCGCGCCGTTCAGACG
GCATACGCCCCGCCGCCTTCGCCTGAAGGCAAAATGCCGTCTGAAGGGGCGGCATGCGGCACAGACCCCGGCGGCATACT
GGATAAAATGGGTTTCGACCCGGTTCATCCCGACGTGCTTGCCGAGCAGCTTGCTATGCCTGCCGCAGATTTGTATGCCG
CACTGTTGGAATTGGAATTGGACGGCAGCGTTGCCGCAATGCCCGGCGGCAGATACCAGCGTATCCGAACTTGA

Domains

Predicted by InterproScan.

DprA winged helix domain (DprA_WH)

(340-390)

DNA recombination-mediator protein A (DNA_processg_A)

(79-282)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A121S8B3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  dprA Neisseria gonorrhoeae strain FA1090

94.207

100

0.942
  dprA Neisseria gonorrhoeae MS11

93.955

100

0.94
  dprA Neisseria meningitidis strain C311

90.176

100

0.902
  dprA Neisseria meningitidis MC58

90.176

100

0.902
  dprA Glaesserella parasuis strain SC1401

39.844

96.725

0.385
  dprA Vibrio cholerae strain A1552

37.531

100

0.375

Multiple sequence alignment