Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   H7786_RS02600 Genome accession   NZ_CP060649
Coordinates   497532..498242 (+) Length   236 a.a.
NCBI ID   WP_002985645.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY270     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 492532..503242
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7786_RS02580 (H7786_02615) - 493387..493533 (+) 147 WP_030126094.1 hypothetical protein -
  H7786_RS02585 (H7786_02620) - 493928..495076 (+) 1149 WP_030126093.1 acetyl-CoA C-acyltransferase -
  H7786_RS02590 (H7786_02625) - 495033..496280 (+) 1248 WP_014407393.1 AMP-binding protein -
  H7786_RS02595 (H7786_02630) - 496336..497370 (+) 1035 WP_174147118.1 DUF3114 domain-containing protein -
  H7786_RS02600 (H7786_02635) vicR 497532..498242 (+) 711 WP_002985645.1 response regulator YycF Regulator
  H7786_RS02605 (H7786_02640) vicK 498235..499587 (+) 1353 WP_030126091.1 cell wall metabolism sensor histidine kinase VicK Regulator
  H7786_RS02610 (H7786_02645) vicX 499591..500400 (+) 810 WP_002985641.1 MBL fold metallo-hydrolase Regulator
  H7786_RS02615 (H7786_02650) rnc 500843..501535 (+) 693 WP_002990670.1 ribonuclease III -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27083.99 Da        Isoelectric Point: 4.9038

>NTDB_id=477523 H7786_RS02600 WP_002985645.1 497532..498242(+) (vicR) [Streptococcus pyogenes strain TSPY270]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=477523 H7786_RS02600 WP_002985645.1 497532..498242(+) (vicR) [Streptococcus pyogenes strain TSPY270]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAACCCTTTTCTAATCGGGA
ATTGCTGGCACGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACCCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGTCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGTCTCCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364