Detailed information NTG0477369

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: H7789_RS04870
• Genome accession: NZ_CP060646
• Coordinates: 972973..973809 (-)
• Length: 278 a.a.
• NCBI ID: WP_136110089.1
• Uniprot ID: A0A6C2WA92
• Organism: Streptococcus pyogenes strain TSPY1026
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 967973..978809

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7789_RS04850 (H7789_04845)	-	968191..969183 (-)	993	WP_136260986.1	D-lactate dehydrogenase	-
H7789_RS04855 (H7789_04850)	-	969198..969764 (-)	567	Protein_903	PTS sugar transporter subunit IIC	-
H7789_RS04860 (H7789_04855)	-	969804..970661 (+)	858	Protein_904	LysR family transcriptional regulator	-
H7789_RS04865 (H7789_04860)	topA	970736..972865 (-)	2130	WP_011017773.1	type I DNA topoisomerase	-
H7789_RS04870 (H7789_04865)	dprA	972973..973809 (-)	837	WP_136110089.1	DNA-processing protein DprA	Machinery gene
H7789_RS04875 (H7789_04870)	-	973874..974665 (-)	792	WP_136296845.1	ribonuclease HII	-
H7789_RS04880 (H7789_04875)	ylqF	974655..975503 (-)	849	WP_136260983.1	ribosome biogenesis GTPase YlqF	-
H7789_RS04885 (H7789_04880)	-	975722..976162 (+)	441	WP_011017769.1	DUF1836 domain-containing protein	-
H7789_RS04890 (H7789_04885)	trhA	976159..976809 (+)	651	WP_136047671.1	PAQR family membrane homeostasis protein TrhA	-
H7789_RS04895 (H7789_04890)	-	976926..977837 (+)	912	WP_047235287.1	diacylglycerol/lipid kinase family protein	-
H7789_RS04900 (H7789_04895)	-	977887..978327 (-)	441	WP_136260982.1	hypothetical protein	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 30978.99 Da
• Isoelectric Point: 9.2511

>NTDB_id=477369 H7789_RS04870 WP_136110089.1 972973..973809(-) (dprA) [Streptococcus pyogenes strain TSPY1026]
MNHFELYKLKKAGLTNKNILNILDYQKQQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPGEEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=477369 H7789_RS04870 WP_136110089.1 972973..973809(-) (dprA) [Streptococcus pyogenes strain TSPY1026]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAAA
ACAACAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTCGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAATCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAGGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A6C2WA92

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.266	100	0.673
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.554	100	0.576
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367