Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   LLH_RS11840 Genome accession   NC_017492
Coordinates   2276907..2278130 (+) Length   407 a.a.
NCBI ID   WP_011836058.1    Uniprot ID   A0A1E7G0Y5
Organism   Lactococcus cremoris subsp. cremoris A76     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2271907..2283130
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LLH_RS11810 (llh_12370) - 2272015..2272818 (-) 804 WP_011677190.1 phosphatidate cytidylyltransferase -
  LLH_RS11815 (llh_12375) - 2272818..2273552 (-) 735 WP_014573345.1 isoprenyl transferase -
  LLH_RS11820 (llh_12380) yajC 2273902..2274234 (-) 333 WP_011677192.1 preprotein translocase subunit YajC -
  LLH_RS11825 (llh_12385) - 2274395..2274832 (-) 438 WP_014573346.1 DNA alkylation repair protein -
  LLH_RS13455 (llh_12390) - 2274885..2275775 (-) 891 WP_014573347.1 IS982 family transposase -
  LLH_RS11830 (llh_12395) - 2275852..2276034 (-) 183 WP_014573348.1 DNA alkylation repair protein -
  LLH_RS11835 (llh_12400) rlmH 2276052..2276531 (-) 480 WP_011677194.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  LLH_RS11840 (llh_12405) htrA 2276907..2278130 (+) 1224 WP_011836058.1 S1C family serine protease Regulator
  LLH_RS11845 (llh_12410) - 2278252..2279250 (+) 999 WP_014573349.1 glycosyltransferase family 4 protein -
  LLH_RS11850 (llh_12415) - 2279388..2280728 (+) 1341 WP_014573350.1 glycosyltransferase family 4 protein -
  LLH_RS11855 (llh_12420) - 2280836..2281060 (+) 225 WP_011677198.1 YkuJ family protein -
  LLH_RS11860 (llh_12425) - 2281204..2282208 (+) 1005 WP_014573351.1 hypothetical protein -
  LLH_RS11865 (llh_12430) - 2282265..2283017 (-) 753 WP_014573352.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -

Sequence

Protein


Download         Length: 407 a.a.        Molecular weight: 41540.99 Da        Isoelectric Point: 5.3802

>NTDB_id=47715 LLH_RS11840 WP_011836058.1 2276907..2278130(+) (htrA) [Lactococcus cremoris subsp. cremoris A76]
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQLGNANRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKQNS
QSDFSSIFGGNSGSSSANDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKATVVGYDEYTDLAVL
KISSDHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTSINAIQTDAAINPGNSGG
ALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLETDGKISRPALGIRMVDLSQLSTNDSSQLKLPSS
VTGGVVVYSVQAGLPAATAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSATANVKLSKSTSDLET
NSSSSSN

Nucleotide


Download         Length: 1224 bp        

>NTDB_id=47715 LLH_RS11840 WP_011836058.1 2276907..2278130(+) (htrA) [Lactococcus cremoris subsp. cremoris A76]
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACCGGTGTTGTGGGTGGAGCTATCGCACTCGGAGGAAGCGCAATTTA
TCAAAGCACTACAAACCAACTAGGAAATGCTAACCGCTCAAATACAACTAGCACAAAGGTTAGTAATGTTTCGGTAAATG
TCAATACCGATGTCACCTCTGCAATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAACAGAATTCA
CAAAGTGATTTTAGTTCAATTTTTGGTGGAAATAGCGGCTCAAGTTCAGCTAATGACGGCTTGCAACTTTCCAGTGAGGG
TTCTGGTGTTATTTATAAAAAATCTGGTGGAGATGCTTACGTGGTCACTAACTATCACGTTATTGCTGGAAATAGTTCCC
TCGATGTTTTACTTTCTGGTGGGCAAAAAGTTAAAGCCACAGTTGTTGGTTATGATGAATACACTGACCTTGCCGTTCTT
AAAATCAGCTCTGACCATGTTAAAGACGTGGCAACTTTCGCTGATTCAAGCAAGTTAACTATTGGTGAACCAGCTATTGC
AGTCGGCTCACCTTTAGGTAGCCAGTTTGCTAATACTGCAACCGAAGGAATTCTGTCTGCAACAAGTCGTCAAGTCACTT
TGACTCAAGAAAATGGTCAAACAACAAGTATCAATGCGATTCAAACGGATGCTGCCATTAACCCGGGTAACTCAGGTGGA
GCCTTGATTAATATTGAAGGTCAAGTGATTGGTATTACTCAAAGTAAAATCACAACGACCGAAGATGGTTCTACCTCTGT
GGAAGGTTTAGGTTTTGCTATCCCATCTAATGATGTGGTAAACATCATTAATAAACTTGAAACTGATGGTAAGATTTCAC
GTCCTGCCTTAGGTATTCGTATGGTTGACCTATCTCAATTATCAACAAATGATAGTTCTCAACTGAAATTACCTAGCAGC
GTAACTGGTGGAGTGGTTGTCTACTCTGTTCAAGCGGGTCTTCCTGCTGCCACAGCTGGTCTGAAAGCTGGCGATGTGAT
AACGAAGGTGGGAGATACCGCCGTTACTTCATCAACAGACTTACAAAGTGCTCTTTACTCACACAATATTAATGATACTG
TGAAAGTCACCTACTACCGTGATGGTAAATCAGCCACAGCAAATGTTAAACTCTCTAAATCAACAAGCGATTTAGAAACA
AATAGTTCATCTTCTTCTAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(250-395)

Trypsin-like peptidase domain (Trypsin_2)

(107-252)

PDZ domain (PDZ_2)

(295-391)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1E7G0Y5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

55.128

95.823

0.528
  htrA Streptococcus mitis NCTC 12261

55.875

94.103

0.526
  htrA Streptococcus pneumoniae R6

58.14

84.521

0.491
  htrA Streptococcus pneumoniae TIGR4

58.14

84.521

0.491
  htrA Streptococcus pneumoniae D39

58.14

84.521

0.491
  htrA Streptococcus pneumoniae Rx1

58.14

84.521

0.491
  htrA Streptococcus mutans UA159

53.388

90.663

0.484

Multiple sequence alignment