Detailed information NTG0047692

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: LLH_RS04420
• Genome accession: NC_017492
• Coordinates: 866171..866863 (+)
• Length: 230 a.a.
• NCBI ID: WP_011676631.1
• Uniprot ID: A0A0M2ZTN8
• Organism: Lactococcus cremoris subsp. cremoris A76
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 861171..871863

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLH_RS13550	-	861496..861633 (-)	138	Protein_845	Ltp family lipoprotein	-
LLH_RS04390	arsC	861826..862230 (+)	405	WP_041168192.1	arsenate reductase (thioredoxin)	-
LLH_RS04395 (llh_4530)	-	862342..863178 (+)	837	WP_041168193.1	metallophosphoesterase	-
LLH_RS04400	-	863271..864183 (+)	913	Protein_848	CHAP domain-containing protein	-
LLH_RS04405	-	864420..864782 (+)	363	WP_011834859.1	TIGR02328 family protein	-
LLH_RS04410 (llh_4545)	-	865106..865351 (+)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
LLH_RS04415 (llh_4550)	-	865484..866014 (+)	531	WP_014572328.1	DUF177 domain-containing protein	-
LLH_RS04420 (llh_4555)	covR	866171..866863 (+)	693	WP_011676631.1	response regulator transcription factor	Regulator
LLH_RS04425 (llh_4560)	covS	866876..868348 (+)	1473	WP_041168194.1	HAMP domain-containing histidine kinase	Regulator
LLH_RS04430 (llh_4565)	-	868535..869776 (+)	1242	WP_014572330.1	ammonium transporter	-
LLH_RS04435 (llh_4570)	-	869858..870199 (+)	342	WP_011676628.1	P-II family nitrogen regulator	-
LLH_RS04440 (llh_4575)	murD	870368..871717 (+)	1350	WP_011834864.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26654.33 Da
• Isoelectric Point: 5.1273

>NTDB_id=47692 LLH_RS04420 WP_011676631.1 866171..866863(+) (covR) [Lactococcus cremoris subsp. cremoris A76]
MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=47692 LLH_RS04420 WP_011676631.1 866171..866863(+) (covR) [Lactococcus cremoris subsp. cremoris A76]
ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG
CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGCCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG
ACCGCGCGTGATTCAACAATGGACCGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT
TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCATGCTGTAGAACGTGCTGAAAACACTT
CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGCGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA
TACGATCTTCTTTTGACGTTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA
GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: A0A0M2ZTN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361