Detailed information NTG0469212

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: H1A19_RS06410
• Genome accession: NZ_CP059383
• Coordinates: 1223843..1224685 (+)
• Length: 280 a.a.
• NCBI ID: WP_001015240.1
• Uniprot ID: Q8DZU1
• Organism: Streptococcus agalactiae strain BJ01
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1218843..1229685

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1A19_RS06385 (H1A19_06385)	-	1219137..1219685 (+)	549	WP_000136509.1	sugar O-acetyltransferase	-
H1A19_RS06390 (H1A19_06390)	-	1219924..1220886 (+)	963	WP_000735588.1	ABC transporter permease	-
H1A19_RS06395 (H1A19_06395)	-	1220883..1221857 (+)	975	WP_000588576.1	iron chelate uptake ABC transporter family permease subunit	-
H1A19_RS06400 (H1A19_06400)	-	1221854..1222615 (+)	762	WP_000614752.1	ABC transporter ATP-binding protein	-
H1A19_RS06405 (H1A19_06405)	-	1222677..1223705 (+)	1029	WP_000162771.1	siderophore ABC transporter substrate-binding protein	-
H1A19_RS06410 (H1A19_06410)	dprA	1223843..1224685 (+)	843	WP_001015240.1	DNA-processing protein DprA	Machinery gene
H1A19_RS06415 (H1A19_06415)	topA	1224780..1226900 (+)	2121	WP_000246611.1	type I DNA topoisomerase	-
H1A19_RS06420 (H1A19_06420)	-	1227037..1227738 (+)	702	WP_000120355.1	ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 280 a.a.
• Molecular weight: 31294.36 Da
• Isoelectric Point: 9.3802

>NTDB_id=469212 H1A19_RS06410 WP_001015240.1 1223843..1224685(+) (dprA) [Streptococcus agalactiae strain BJ01]
MNHFELFKLKKAGLTNLNIHNIINYLKKNSLTSLSVRNMAVVSKCKNPTFFIENYKQLDLKKLRQEFKKFPVLSILDSNY
PLELKEIYNPPVLLFYQGNIELLSKPKLAVVGARQASQIGCQSVKKIIKETNNQFVIVSGLARGIDTAAHVSALKNGGSS
IAVIGSGLDVYYPTENKKLQEYMSYNHLVLSEYFTGEQPLKFHFPERNRIIAGLCQGIVVAEAKMRSGSLITCERALEEG
REVFAIPGNIIDGKSDGCHHLIQEGAKCIISGKDILSEYQ

Nucleotide

• Length: 843 bp

>NTDB_id=469212 H1A19_RS06410 WP_001015240.1 1223843..1224685(+) (dprA) [Streptococcus agalactiae strain BJ01]
ATGAATCATTTTGAACTATTTAAGCTTAAAAAAGCTGGATTAACAAATCTTAATATCCACAATATTATCAACTATCTCAA
AAAGAATAGTTTAACTTCTCTATCTGTTCGCAATATGGCCGTAGTATCAAAATGTAAAAATCCTACTTTCTTTATAGAAA
ATTATAAACAGCTAGACCTTAAAAAACTTCGACAAGAATTCAAAAAATTTCCAGTTCTATCGATTTTGGATTCTAACTAT
CCTTTAGAGTTAAAAGAAATATATAATCCACCAGTTCTACTTTTTTATCAGGGTAATATTGAACTTCTATCTAAACCTAA
ATTAGCTGTAGTGGGGGCAAGACAGGCATCTCAGATAGGTTGTCAGTCTGTTAAAAAGATTATCAAGGAGACTAACAATC
AATTTGTTATCGTAAGTGGTTTAGCGCGTGGCATTGATACAGCAGCACATGTTAGTGCTTTAAAAAATGGCGGCAGTAGT
ATAGCTGTTATCGGGAGTGGTTTAGATGTTTATTATCCAACGGAGAATAAGAAACTTCAAGAATATATGTCATATAATCA
TCTCGTATTATCAGAATATTTTACCGGAGAACAACCCTTGAAATTTCATTTCCCCGAACGTAACCGTATTATTGCAGGGC
TGTGTCAAGGTATTGTGGTTGCCGAAGCTAAGATGAGATCTGGAAGTTTAATTACCTGTGAAAGAGCATTAGAAGAGGGA
CGAGAAGTTTTTGCCATTCCCGGAAATATTATCGATGGCAAATCAGATGGATGCCACCATCTTATCCAAGAAGGAGCTAA
ATGCATTATTTCAGGAAAAGATATCCTTTCTGAATATCAGTAG

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (69-270)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-63)

3D structure

• AlphaFold DB: Q8DZU1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	70.251	99.643	0.7
dprA/cilB/dalA	Streptococcus mitis SK321	62.5	100	0.625
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	61.786	100	0.618
dprA/cilB/dalA	Streptococcus pneumoniae D39	61.786	100	0.618
dprA/cilB/dalA	Streptococcus pneumoniae R6	61.786	100	0.618
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	61.786	100	0.618
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	61.429	100	0.614
dprA	Lactococcus lactis subsp. cremoris KW2	60.932	99.643	0.607
dprA	Latilactobacillus sakei subsp. sakei 23K	42.231	89.643	0.379