Detailed information NTG0457160

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: HVV27_RS04655
• Genome accession: NZ_CP055246
• Coordinates: 926031..926867 (+)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain TSPY767
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 921031..931867

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HVV27_RS04625 (HVV27_04625)	-	921519..921953 (+)	435	WP_021299262.1	hypothetical protein	-
HVV27_RS04630 (HVV27_04630)	-	922003..922914 (-)	912	WP_011528643.1	diacylglycerol kinase family protein	-
HVV27_RS04635 (HVV27_04635)	-	923031..923681 (-)	651	WP_002984629.1	hemolysin III family protein	-
HVV27_RS04640 (HVV27_04640)	-	923678..924118 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
HVV27_RS04645 (HVV27_04645)	ylqF	924337..925185 (+)	849	WP_011017770.1	ribosome biogenesis GTPase YlqF	-
HVV27_RS04650 (HVV27_04650)	-	925175..925966 (+)	792	WP_011017771.1	ribonuclease HII	-
HVV27_RS04655 (HVV27_04655)	dprA	926031..926867 (+)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
HVV27_RS04660 (HVV27_04660)	topA	926974..929103 (+)	2130	WP_011528644.1	type I DNA topoisomerase	-
HVV27_RS04665 (HVV27_04665)	-	929179..930063 (-)	885	Protein_890	LysR family transcriptional regulator	-
HVV27_RS04670 (HVV27_04670)	-	930076..930642 (+)	567	Protein_891	PTS sugar transporter subunit IIC	-
HVV27_RS04675 (HVV27_04675)	-	930657..931649 (+)	993	WP_021299266.1	D-lactate dehydrogenase	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=457160 HVV27_RS04655 WP_011017772.1 926031..926867(+) (dprA) [Streptococcus pyogenes strain TSPY767]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=457160 HVV27_RS04655 WP_011017772.1 926031..926867(+) (dprA) [Streptococcus pyogenes strain TSPY767]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367