Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   FOC72_RS05620 Genome accession   NZ_CP054570
Coordinates   1152421..1153095 (-) Length   224 a.a.
NCBI ID   WP_002895755.1    Uniprot ID   A0A0B7GPK5
Organism   Streptococcus sanguinis strain FDAARGOS_770     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1147421..1158095
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FOC72_RS05600 (FOC72_05600) - 1148127..1149524 (-) 1398 WP_002895744.1 polysaccharide deacetylase family protein -
  FOC72_RS05605 (FOC72_05605) - 1149586..1149972 (-) 387 WP_002895748.1 VOC family protein -
  FOC72_RS05610 (FOC72_05610) - 1150086..1151024 (-) 939 WP_002895751.1 ketopantoate reductase family protein -
  FOC72_RS05615 (FOC72_05615) ciaH 1151040..1152431 (-) 1392 WP_002895754.1 cell wall metabolism sensor histidine kinase WalK Regulator
  FOC72_RS05620 (FOC72_05620) ciaR 1152421..1153095 (-) 675 WP_002895755.1 response regulator transcription factor Regulator
  FOC72_RS05625 (FOC72_05625) - 1153200..1153679 (-) 480 WP_002895756.1 hypothetical protein -
  FOC72_RS05630 (FOC72_05630) - 1153986..1156526 (-) 2541 WP_002895758.1 M1 family metallopeptidase -
  FOC72_RS05635 (FOC72_05635) - 1156695..1157021 (-) 327 WP_002895760.1 hypothetical protein -
  FOC72_RS05640 (FOC72_05640) - 1157030..1157326 (-) 297 WP_002895761.1 hypothetical protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25266.01 Da        Isoelectric Point: 4.4378

>NTDB_id=453498 FOC72_RS05620 WP_002895755.1 1152421..1153095(-) (ciaR) [Streptococcus sanguinis strain FDAARGOS_770]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLRAKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLSYGDVTVNLSTNSTLKDGKDVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTAFAKNLHTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=453498 FOC72_RS05620 WP_002895755.1 1152421..1153095(-) (ciaR) [Streptococcus sanguinis strain FDAARGOS_770]
ATGATTAAAATTCTATTGGTAGAAGATGACCTTGGACTGTCAAACTCAGTTTTTGATTTTTTAGATGATTTTGCGGATGT
AATGCAGGTTTTTGATGGTGAAGAAGGTCTATATGAAGCAGAAAGCGGTGTTTATGACCTCATCTTGCTGGATCTCATGC
TGCCTGAAAAGGACGGTTTCCAAGTGCTGAAAGATCTCCGAGCAAAAGGAGTTACAACACCTGTTCTCATCATGACAGCT
AAGGAAAGCTTGGATGACAAAGGACATGGCTTTGAGCTTGGGGCTGATGACTATCTGACAAAACCTTTCTATTTGGAAGA
ACTGAAAATGCGGATCCAGGCGCTCTTGAAACGCGCTGGCAAGTTCAACGAGAATACTCTTTCTTATGGCGATGTGACGG
TCAATCTATCCACAAATTCAACATTGAAAGACGGTAAAGACGTGGAGTTGCTTGGTAAAGAGTTCGACCTCTTGGTTTAT
TTCCTGCAAAATCAAAATGTAATCTTGCCTAAGACTCAAATTTTTGACCGTCTGTGGGGCTTTGACAGTGATACCACTGT
TTCCGTTGTCGAAGTGTACGTTTCAAAGATTCGTAAAAAACTGAAAGGAACGGCATTTGCGAAAAACCTACATACTCTTC
GTAGTGTCGGCTACATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7GPK5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

88.839

100

0.888
  ciaR Streptococcus pneumoniae D39

88.839

100

0.888
  ciaR Streptococcus pneumoniae R6

88.839

100

0.888
  ciaR Streptococcus pneumoniae TIGR4

88.839

100

0.888
  ciaR Streptococcus mutans UA159

87.444

99.554

0.871
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.207

100

0.397
  vicR Streptococcus mutans UA159

35.622

100

0.371