Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   HQ939_RS03625 Genome accession   NZ_CP054198
Coordinates   652620..653882 (+) Length   420 a.a.
NCBI ID   WP_075604702.1    Uniprot ID   A0A6M8T049
Organism   Glaesserella parasuis strain YHP170504     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 647620..658882
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HQ939_RS03600 (HQ939_03605) - 647802..650369 (-) 2568 WP_075606140.1 penicillin-binding protein 1A -
  HQ939_RS03605 (HQ939_03610) comA 650523..651200 (+) 678 WP_021112067.1 hypothetical protein Machinery gene
  HQ939_RS03610 (HQ939_03615) comB 651176..651697 (+) 522 WP_021112068.1 hypothetical protein Machinery gene
  HQ939_RS03615 (HQ939_03620) comC 651694..652224 (+) 531 WP_075606141.1 ATPase Machinery gene
  HQ939_RS03620 (HQ939_03625) comD 652269..652610 (+) 342 WP_021114623.1 pilus assembly, PilP family protein Machinery gene
  HQ939_RS03625 (HQ939_03630) comE 652620..653882 (+) 1263 WP_075604702.1 type IV pilus secretin PilQ Machinery gene
  HQ939_RS03630 (HQ939_03635) nusB 653961..654374 (+) 414 WP_021112072.1 transcription antitermination factor NusB -
  HQ939_RS03635 (HQ939_03640) thiL 654383..655351 (+) 969 WP_021112073.1 thiamine-phosphate kinase -
  HQ939_RS03640 (HQ939_03645) - 655354..655824 (+) 471 WP_021117942.1 phosphatidylglycerophosphatase A -
  HQ939_RS03645 (HQ939_03650) - 655826..656455 (+) 630 WP_015940164.1 LysE family transporter -
  HQ939_RS03650 (HQ939_03655) trxA 656752..657066 (+) 315 WP_015940165.1 thioredoxin -
  HQ939_RS03655 (HQ939_03660) - 657551..657901 (+) 351 WP_043894779.1 hypothetical protein -
  HQ939_RS03660 (HQ939_03665) - 658054..658473 (-) 420 WP_021112075.1 hotdog fold thioesterase -

Sequence

Protein


Download         Length: 420 a.a.        Molecular weight: 47068.95 Da        Isoelectric Point: 7.7191

>NTDB_id=451399 HQ939_RS03625 WP_075604702.1 652620..653882(+) (comE) [Glaesserella parasuis strain YHP170504]
MRYLFLLFFATFPVLANQQISLSIRNAPTAEIISYLAEETGKNITISDEIKDTKNFRVEKSHFDEILNSLIKTHQLNLKK
ENGIYYIHQAQEHKQHTTAQLVNALPKLITKTIKLHYSKASEVIESLTKGQGNLLSESGYLHFDDRSNSIIVKDSAASVK
NFTQLIESLDKPTEQIAIEARIVTISSEHLQQLGVRWGLFSPNENHYKLAGNLEGNGLTTNNLNVNFPVNPSASVALQIA
AINSRVLDLELTALESENNIEIIASPRLLTTDKKPASIKQGTEIPYAMYSKKEEITDIEFREAVLGLEVTPHISKQNQIL
LDLAISQNSPNNQINNTMVTIDKQEIKTQVLAKHGETIVLGGIFQHLIAKGEDKVPLLGSIPVIKRLFSQNRDRISKREL
VIFVTPYIVKSEKMGAEKQK

Nucleotide


Download         Length: 1263 bp        

>NTDB_id=451399 HQ939_RS03625 WP_075604702.1 652620..653882(+) (comE) [Glaesserella parasuis strain YHP170504]
ATGCGTTATTTATTTCTGCTCTTCTTTGCTACTTTTCCTGTATTAGCAAACCAACAAATTTCACTTTCGATAAGAAATGC
CCCAACGGCAGAGATTATTAGTTATTTGGCGGAGGAAACGGGAAAGAATATTACAATTTCGGATGAAATTAAAGATACAA
AAAATTTCAGAGTAGAAAAAAGCCATTTTGATGAGATATTAAATAGTTTAATCAAAACACATCAATTAAATTTAAAAAAA
GAAAATGGCATTTACTATATTCATCAAGCCCAAGAACATAAACAACATACTACGGCACAATTAGTTAATGCTCTGCCTAA
ATTAATCACCAAAACAATCAAGTTACACTATTCCAAAGCCTCTGAAGTTATAGAGTCTTTAACAAAAGGGCAAGGCAATT
TACTATCAGAAAGTGGTTATCTTCACTTTGATGATCGCAGTAATAGCATTATCGTCAAAGACAGTGCCGCCTCAGTTAAA
AACTTTACTCAACTTATCGAAAGCCTAGATAAACCAACGGAACAAATTGCAATTGAAGCCCGAATTGTCACTATCAGCAG
TGAACATTTACAACAACTTGGCGTGCGTTGGGGCTTATTTTCCCCTAACGAAAATCACTACAAATTGGCAGGCAATTTAG
AAGGCAACGGATTAACTACCAACAACTTAAACGTAAATTTTCCAGTAAATCCGTCCGCTTCTGTTGCCTTACAAATTGCT
GCAATCAACAGCCGTGTACTTGATTTAGAACTTACTGCATTAGAAAGCGAAAATAACATAGAGATCATTGCAAGCCCTCG
CTTACTCACAACAGATAAAAAACCAGCGAGTATCAAACAAGGTACAGAAATTCCTTATGCAATGTACAGTAAGAAAGAGG
AAATCACCGATATTGAATTTCGTGAAGCCGTTTTGGGGTTAGAGGTCACGCCACATATTTCTAAACAAAATCAGATTTTG
TTAGACCTCGCTATCAGCCAAAATTCGCCCAATAACCAAATAAATAATACAATGGTGACAATTGATAAACAGGAAATCAA
AACGCAAGTTCTAGCTAAACACGGTGAAACCATCGTATTAGGCGGTATTTTTCAACATCTGATCGCCAAAGGCGAAGATA
AAGTACCGCTGTTAGGCAGTATCCCCGTGATTAAACGCTTATTTAGCCAAAATCGAGATAGAATCTCTAAACGAGAATTA
GTGATTTTTGTTACGCCTTATATTGTAAAATCTGAAAAAATGGGAGCGGAAAAGCAGAAATAA

Domains

Predicted by InterproScan.

Bacterial type II/III secretion system short domain (Secretin_N)

(110-175)

Bacterial type II and III secretion system protein (Secretin)

(253-410)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6M8T049

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Glaesserella parasuis strain SC1401

98.81

100

0.988
  comE Haemophilus influenzae Rd KW20

53.176

100

0.538
  comE Haemophilus influenzae 86-028NP

52.235

100

0.529
  pilQ Vibrio cholerae O1 biovar El Tor strain E7946

38.164

98.571

0.376
  pilQ Vibrio cholerae strain A1552

38.164

98.571

0.376
  pilQ Vibrio campbellii strain DS40M4

36.967

100

0.371