NTDB

Overview

Name	vicR	Type	Regulator
Locus tag	HQ616_RS04065	Genome accession	NZ_CP053891
Coordinates	750762..751472 (+)	Length	236 a.a.
NCBI ID	WP_000722052.1	Uniprot ID	X5K3L1
Organism	Streptococcus agalactiae strain GBS20
Function	repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 745762..756472

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HQ616_RS04040 (HQ616_04015)	-	746870..747436 (+)	567	WP_000592389.1	PepSY domain-containing protein	-
HQ616_RS04045 (HQ616_04020)	-	747485..748135 (-)	651	WP_000100034.1	amino acid ABC transporter permease	-
HQ616_RS04050 (HQ616_04025)	-	748147..748842 (-)	696	WP_000173640.1	amino acid ABC transporter permease	-
HQ616_RS04055 (HQ616_04030)	-	748855..749655 (-)	801	WP_000946171.1	transporter substrate-binding domain-containing protein	-
HQ616_RS04060 (HQ616_04035)	-	749667..750422 (-)	756	WP_000053154.1	amino acid ABC transporter ATP-binding protein	-
HQ616_RS04065 (HQ616_04040)	vicR	750762..751472 (+)	711	WP_000722052.1	response regulator YycF	Regulator
HQ616_RS04070 (HQ616_04045)	vicK	751465..752814 (+)	1350	WP_001065469.1	cell wall metabolism sensor histidine kinase VicK	Regulator
HQ616_RS04075 (HQ616_04050)	vicX	752818..753627 (+)	810	WP_001289499.1	MBL fold metallo-hydrolase	Regulator
HQ616_RS04080 (HQ616_04055)	-	753630..753998 (+)	369	WP_000719384.1	YbaN family protein	-
HQ616_RS04085 (HQ616_04060)	rnc	754174..754860 (+)	687	WP_000661526.1	ribonuclease III	-

Sequence

Protein

Download Length: 236 a.a. Molecular weight: 27063.90 Da Isoelectric Point: 4.8246

                                >NTDB_id=448745 HQ616_RS04065 WP_000722052.1 750762..751472(+) (vicR) [Streptococcus agalactiae strain GBS20]

MKKILIVDDEKPISDIIKFNLTKEGYETATAFDGREALVQYAEFQPDLIILDLMLPELDGLEVAKEVRKTSHIPIIMLSA

KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTENIETAVAEESAQNASSDITIGELQILPDAFIAKKRGEEIE

LTHREFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPGRPEYILTRRGVGYYMKSYE

Nucleotide

Download Length: 711 bp

                                >NTDB_id=448745 HQ616_RS04065 WP_000722052.1 750762..751472(+) (vicR) [Streptococcus agalactiae strain GBS20]

ATGAAAAAAATACTTATCGTTGATGATGAAAAACCAATTTCAGATATTATCAAATTTAATTTAACCAAAGAAGGATATGA

GACGGCGACAGCTTTCGATGGCCGTGAAGCTTTAGTACAATATGCAGAATTTCAACCAGATTTAATCATTTTGGATTTAA

TGCTCCCTGAACTAGATGGTTTAGAAGTGGCTAAAGAAGTTCGTAAAACCAGCCATATTCCTATTATTATGCTTTCTGCA

AAAGATAGTGAGTTTGACAAAGTCATTGGTTTAGAAATCGGTGCAGATGATTATGTTACTAAACCTTTTTCAAATCGTGA

ACTTTTGGCACGGGTCAAAGCACATTTACGACGTACTGAAAATATTGAAACAGCTGTAGCAGAAGAAAGTGCTCAAAATG

CTTCTTCGGATATTACTATTGGTGAGTTGCAAATTTTACCAGACGCCTTTATTGCTAAGAAACGTGGCGAAGAAATTGAA

TTAACGCACCGAGAATTTGAATTACTTCACCATTTAGCGACACATATCGGACAAGTCATGACACGCGAACATTTATTGGA

AACAGTTTGGGGATATGATTATTTTGGAGATGTCCGTACAGTTGATGTGACGGTGAGACGTTTACGTGAAAAGATTGAAG

ATACTCCTGGTCGTCCAGAATATATTTTGACTCGACGTGGTGTAGGTTATTACATGAAGTCTTATGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)

Response regulator receiver domain (Response_reg)

(4-113)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	X5K3L1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
vicR	Streptococcus mutans UA159	88.983	100	0.89
micA	Streptococcus pneumoniae Cp1015	77.778	99.153	0.771
covR	Lactococcus lactis subsp. lactis strain DGCC12653	46.983	98.305	0.462
covR	Streptococcus salivarius strain HSISS4	44.635	98.729	0.441
scnR	Streptococcus mutans UA159	38.559	100	0.386

Detailed information NTG0448745