Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   HQ616_RS04070 Genome accession   NZ_CP053891
Coordinates   751465..752814 (+) Length   449 a.a.
NCBI ID   WP_001065469.1    Uniprot ID   R4ZB13
Organism   Streptococcus agalactiae strain GBS20     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 746465..757814
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HQ616_RS04040 (HQ616_04015) - 746870..747436 (+) 567 WP_000592389.1 PepSY domain-containing protein -
  HQ616_RS04045 (HQ616_04020) - 747485..748135 (-) 651 WP_000100034.1 amino acid ABC transporter permease -
  HQ616_RS04050 (HQ616_04025) - 748147..748842 (-) 696 WP_000173640.1 amino acid ABC transporter permease -
  HQ616_RS04055 (HQ616_04030) - 748855..749655 (-) 801 WP_000946171.1 transporter substrate-binding domain-containing protein -
  HQ616_RS04060 (HQ616_04035) - 749667..750422 (-) 756 WP_000053154.1 amino acid ABC transporter ATP-binding protein -
  HQ616_RS04065 (HQ616_04040) vicR 750762..751472 (+) 711 WP_000722052.1 response regulator YycF Regulator
  HQ616_RS04070 (HQ616_04045) vicK 751465..752814 (+) 1350 WP_001065469.1 cell wall metabolism sensor histidine kinase VicK Regulator
  HQ616_RS04075 (HQ616_04050) vicX 752818..753627 (+) 810 WP_001289499.1 MBL fold metallo-hydrolase Regulator
  HQ616_RS04080 (HQ616_04055) - 753630..753998 (+) 369 WP_000719384.1 YbaN family protein -
  HQ616_RS04085 (HQ616_04060) rnc 754174..754860 (+) 687 WP_000661526.1 ribonuclease III -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51059.13 Da        Isoelectric Point: 4.8621

>NTDB_id=448746 HQ616_RS04070 WP_001065469.1 751465..752814(+) (vicK) [Streptococcus agalactiae strain GBS20]
MNNSAANIRSFELALLFLLVFVAVYFVYLAVRDFKMSKNIRLLNWKVRDLIAGNYSDSILIQGDADLVELGESLNDLSDV
FRMAHDNLEQEKNRLASILTYMTDGVLATDRSGKIVMINETAQQQFNLAYDEALSMNIVDMLGSGSPYSFQDLVSKTPEV
VLNRRDENGEFVTLRIRFALNRRESGFISGLVAVSHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALNE
EVAPSFIKVSLDETNRMMRMISDLLSLSRIDNEVTHLDVEMTNFTAFMTSILNRFDQIRNQKTVTGKVYEIVRDYPLKSI
WVEIDTDKMTQVIDNILNNAVKYSPDGGKITVNLRTTKTQMILSISDQGLGIPKKDLPLIFDRFYRVDKARSRQQGGTGL
GLSIAKEIVKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVTYEEWEDVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=448746 HQ616_RS04070 WP_001065469.1 751465..752814(+) (vicK) [Streptococcus agalactiae strain GBS20]
ATGAATAATAGTGCTGCAAATATTAGGTCGTTTGAGCTAGCCTTACTTTTTTTACTAGTTTTTGTTGCTGTCTATTTTGT
TTATCTAGCGGTTAGAGATTTTAAAATGTCTAAAAATATCCGGCTTTTGAATTGGAAAGTCAGAGATTTGATAGCAGGAA
ATTATTCAGATAGTATTCTAATTCAAGGTGATGCAGATTTGGTAGAATTAGGGGAAAGTCTAAATGATTTATCTGATGTC
TTCCGAATGGCACATGATAACTTAGAACAAGAAAAGAATCGCTTAGCAAGTATCTTAACTTATATGACTGACGGTGTGCT
GGCTACAGATCGTTCAGGAAAAATCGTTATGATTAATGAGACAGCCCAACAGCAGTTCAATCTAGCATATGATGAAGCTT
TATCAATGAATATTGTTGATATGTTAGGGTCGGGAAGTCCATATTCGTTCCAAGATTTAGTCTCTAAAACGCCAGAGGTA
GTTCTTAATAGACGTGATGAAAATGGTGAATTTGTTACCTTACGGATTCGATTTGCTTTGAACCGTCGTGAAAGTGGTTT
TATTTCCGGTTTAGTTGCAGTATCACACGATGCTACTGAGCAAGAGAAAGAAGAGCGTGAAAGAAGACTTTTTGTATCTA
ATGTTTCTCATGAACTTCGTACACCTTTGACATCTGTAAAATCTTATTTAGAAGCTTTAGATGAGGGAGCGCTCAATGAA
GAAGTTGCTCCAAGCTTCATTAAGGTATCTCTAGATGAAACAAATCGTATGATGCGTATGATATCAGATTTATTAAGTTT
ATCGCGCATTGATAATGAAGTAACGCATTTAGATGTTGAAATGACGAATTTTACAGCTTTCATGACCTCAATTTTGAATC
GATTTGACCAGATTAGAAATCAAAAAACAGTCACAGGAAAAGTTTATGAAATTGTCAGAGATTATCCTCTTAAGTCAATT
TGGGTGGAAATTGATACAGATAAAATGACTCAAGTGATTGATAACATTTTAAATAATGCAGTCAAGTATTCACCAGATGG
TGGTAAGATTACAGTTAATCTACGCACAACTAAAACGCAGATGATTTTATCAATATCAGACCAAGGCTTAGGTATTCCCA
AAAAAGATTTACCTCTCATCTTTGATCGTTTTTATCGTGTTGATAAGGCGAGAAGTCGTCAACAGGGTGGGACTGGACTT
GGTTTGTCAATTGCAAAAGAAATTGTTAAGCAGCATAAGGGATTTATTTGGGCTAAGAGTGAGTATGGTAAAGGGTCTAC
TTTTACAATCGTCTTGCCTTATGATAAAGATGCTGTAACTTATGAAGAATGGGAGGACGTTGAAGATTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(325-435)

PAS fold (PAS)

(94-180)

His Kinase A (phospho-acceptor) domain (HisKA)

(208-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB R4ZB13

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

74.576

91.982

0.686
  micB Streptococcus pneumoniae Cp1015

67.436

96.437

0.65