NTDB

Overview

Name	micA	Type	Regulator
Locus tag	HKM25_RS05760	Genome accession	NZ_CP053210
Coordinates	1152543..1153247 (-)	Length	234 a.a.
NCBI ID	WP_000722076.1	Uniprot ID	Q9S1K0
Organism	Streptococcus pneumoniae strain 6A-10
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1147543..1158247

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HKM25_RS05735 (HKM25_1172)	-	1147855..1149726 (-)	1872	WP_000150982.1	Eco57I restriction-modification methylase domain-containing protein	-
HKM25_RS05740 (HKM25_1173)	-	1149801..1150055 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HKM25_RS05745 (HKM25_1174)	-	1150057..1150299 (-)	243	WP_000208080.1	DUF6290 family protein	-
HKM25_RS05750 (HKM25_1175)	vicX	1150390..1151199 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
HKM25_RS05755 (HKM25_1176)	micB	1151201..1152550 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
HKM25_RS05760 (HKM25_1177)	micA	1152543..1153247 (-)	705	WP_000722076.1	response regulator YycF	Regulator
HKM25_RS05765 (HKM25_1178)	mutY	1153302..1154477 (-)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
HKM25_RS11950	-	1154577..1154702 (+)	126	WP_001818232.1	hypothetical protein	-
HKM25_RS05770 (HKM25_1179)	-	1154808..1156478 (-)	1671	WP_000845273.1	formate--tetrahydrofolate ligase	-
HKM25_RS05775 (HKM25_1180)	coaB	1156708..1157397 (+)	690	WP_000699495.1	phosphopantothenate--cysteine ligase	-
HKM25_RS05780 (HKM25_1181)	coaC	1157409..1157960 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

Download Length: 234 a.a. Molecular weight: 26815.63 Da Isoelectric Point: 4.7164

                                >NTDB_id=443441 HKM25_RS05760 WP_000722076.1 1152543..1153247(-) (micA) [Streptococcus pneumoniae strain 6A-10]

MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA

KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT

HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

Download Length: 705 bp

                                >NTDB_id=443441 HKM25_RS05760 WP_000722076.1 1152543..1153247(-) (micA) [Streptococcus pneumoniae strain 6A-10]

ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA

AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA

TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC

AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA

GTTGCAGGCACGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC

AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC

CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT

CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC

CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
PDB	1NXS
PDB	2A9O
PDB	2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38

Detailed information NTG0443441