Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   HKM25_RS03770 Genome accession   NZ_CP053210
Coordinates   737799..738473 (+) Length   224 a.a.
NCBI ID   WP_000590640.1    Uniprot ID   D4I4V1
Organism   Streptococcus pneumoniae strain 6A-10     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 732799..743473
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HKM25_RS03750 (HKM25_768) - 732967..733695 (+) 729 WP_000418691.1 GNAT family N-acetyltransferase -
  HKM25_RS03755 (HKM25_769) - 733737..734606 (+) 870 WP_001245823.1 putative PEP-binding protein -
  HKM25_RS03760 (HKM25_770) - 734581..735021 (+) 441 WP_001813258.1 ASCH domain-containing protein -
  HKM25_RS03765 (HKM25_771) - 735144..737690 (+) 2547 WP_001149116.1 M1 family metallopeptidase -
  HKM25_RS03770 (HKM25_772) ciaR 737799..738473 (+) 675 WP_000590640.1 two-component system response regulator CiaR Regulator
  HKM25_RS03775 (HKM25_773) ciaH 738463..739797 (+) 1335 WP_000491790.1 two-component system sensor histidine kinase CiaH Regulator
  HKM25_RS03780 (HKM25_774) - 739831..740118 (-) 288 WP_001145225.1 DUF3270 domain-containing protein -
  HKM25_RS03785 (HKM25_775) - 740258..741187 (+) 930 WP_000411866.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25466.29 Da        Isoelectric Point: 4.3283

>NTDB_id=443432 HKM25_RS03770 WP_000590640.1 737799..738473(+) (ciaR) [Streptococcus pneumoniae strain 6A-10]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=443432 HKM25_RS03770 WP_000590640.1 737799..738473(+) (ciaR) [Streptococcus pneumoniae strain 6A-10]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGTGTCTATGACTTGATTTTGCTGGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGGATTCAGGCCCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D4I4V1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

100

100

1
  ciaR Streptococcus pneumoniae D39

100

100

1
  ciaR Streptococcus pneumoniae R6

100

100

1
  ciaR Streptococcus pneumoniae TIGR4

100

100

1
  ciaR Streptococcus mutans UA159

88.393

100

0.884
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.726

100

0.371
  vicR Streptococcus mutans UA159

35.622

100

0.371