Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   HKM25_RS03775 Genome accession   NZ_CP053210
Coordinates   738463..739797 (+) Length   444 a.a.
NCBI ID   WP_000491790.1    Uniprot ID   Q7B3G0
Organism   Streptococcus pneumoniae strain 6A-10     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 733463..744797
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HKM25_RS03755 (HKM25_769) - 733737..734606 (+) 870 WP_001245823.1 putative PEP-binding protein -
  HKM25_RS03760 (HKM25_770) - 734581..735021 (+) 441 WP_001813258.1 ASCH domain-containing protein -
  HKM25_RS03765 (HKM25_771) - 735144..737690 (+) 2547 WP_001149116.1 M1 family metallopeptidase -
  HKM25_RS03770 (HKM25_772) ciaR 737799..738473 (+) 675 WP_000590640.1 two-component system response regulator CiaR Regulator
  HKM25_RS03775 (HKM25_773) ciaH 738463..739797 (+) 1335 WP_000491790.1 two-component system sensor histidine kinase CiaH Regulator
  HKM25_RS03780 (HKM25_774) - 739831..740118 (-) 288 WP_001145225.1 DUF3270 domain-containing protein -
  HKM25_RS03785 (HKM25_775) - 740258..741187 (+) 930 WP_000411866.1 peptidase U32 family protein -
  HKM25_RS03790 (HKM25_776) - 741387..743837 (+) 2451 WP_000848700.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50673.39 Da        Isoelectric Point: 9.1661

>NTDB_id=443433 HKM25_RS03775 WP_000491790.1 738463..739797(+) (ciaH) [Streptococcus pneumoniae strain 6A-10]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=443433 HKM25_RS03775 WP_000491790.1 738463..739797(+) (ciaH) [Streptococcus pneumoniae strain 6A-10]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAAGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTACGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAAGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q7B3G0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

100

100

1
  ciaH Streptococcus pneumoniae D39

100

100

1
  ciaH Streptococcus pneumoniae R6

100

100

1
  ciaH Streptococcus pneumoniae TIGR4

100

100

1
  ciaH Streptococcus mutans UA159

55.632

97.973

0.545