Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraS   Type   Regulator
Locus tag   HH313_RS10050 Genome accession   NZ_CP053070
Coordinates   2026008..2027051 (-) Length   347 a.a.
NCBI ID   WP_001017131.1    Uniprot ID   A0A0D1IMN4
Organism   Staphylococcus aureus strain HL20709 isolate HL20709     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2021008..2032051
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HH313_RS10020 (HH313_002009) - 2021429..2022685 (-) 1257 WP_078065149.1 aminopeptidase -
  HH313_RS10025 (HH313_002010) - 2022688..2022888 (-) 201 WP_000180460.1 DUF1128 family protein -
  HH313_RS10030 (HH313_002011) - 2023035..2023499 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  HH313_RS10035 (HH313_002012) - 2023506..2023781 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  HH313_RS10040 (HH313_002013) - 2024059..2025276 (+) 1218 WP_000037087.1 YihY/virulence factor BrkB family protein -
  HH313_RS10045 (HH313_002014) vraR 2025389..2026018 (-) 630 WP_000153526.1 two-component system response regulator VraR Regulator
  HH313_RS10050 (HH313_002015) vraS 2026008..2027051 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  HH313_RS10055 (HH313_002016) liaF 2027048..2027749 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  HH313_RS10060 (HH313_002017) - 2027764..2028150 (-) 387 WP_001110179.1 hypothetical protein -
  HH313_RS10065 (HH313_002018) map 2028367..2029125 (-) 759 WP_000636142.1 type I methionyl aminopeptidase -
  HH313_RS10070 (HH313_002019) - 2029654..2030640 (+) 987 WP_000999708.1 aromatic acid exporter family protein -
  HH313_RS10075 (HH313_002020) - 2031073..2031486 (-) 414 WP_025174552.1 hypothetical protein -
  HH313_RS10080 (HH313_002021) - 2031515..2031625 (-) 111 WP_001790257.1 hypothetical protein -

Sequence

Protein


Download         Length: 347 a.a.        Molecular weight: 40044.52 Da        Isoelectric Point: 6.0577

>NTDB_id=442713 HH313_RS10050 WP_001017131.1 2026008..2027051(-) (vraS) [Staphylococcus aureus strain HL20709 isolate HL20709]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide


Download         Length: 1044 bp        

>NTDB_id=442713 HH313_RS10050 WP_001017131.1 2026008..2027051(-) (vraS) [Staphylococcus aureus strain HL20709 isolate HL20709]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(249-340)

Histidine kinase (HisKA_3)

(147-210)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0D1IMN4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraS Staphylococcus aureus N315

100

100

1