Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   IRJ27_RS10360 Genome accession   NZ_CP064095
Coordinates   2026180..2027382 (+) Length   400 a.a.
NCBI ID   WP_009969578.1    Uniprot ID   P39668
Organism   Bacillus subtilis strain N1303-2Ay     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2021180..2032382
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IRJ27_RS10340 walK 2021261..2023096 (+) 1836 WP_009968432.1 cell wall metabolism sensor histidine kinase WalK -
  IRJ27_RS10345 walH 2023086..2024453 (+) 1368 WP_003242498.1 WalRK two-component regulatory system regulator WalH -
  IRJ27_RS10350 walI 2024440..2025282 (+) 843 WP_003244037.1 WalRK two-component regulatory system regulator WalI -
  IRJ27_RS10355 vicX 2025304..2026098 (+) 795 WP_003242676.1 MBL fold metallo-hydrolase Regulator
  IRJ27_RS10360 htrA 2026180..2027382 (+) 1203 WP_009969578.1 serine protease HtrC Regulator
  IRJ27_RS10365 - 2027402..2027530 (+) 129 WP_003242634.1 hypothetical protein -
  IRJ27_RS10370 - 2027647..2027835 (+) 189 Protein_1988 ATP-binding protein -
  IRJ27_RS10375 rocR 2027817..2029202 (-) 1386 WP_003244510.1 arginine utilization regulatory protein RocR -
  IRJ27_RS10380 rocD 2029443..2030648 (+) 1206 WP_003242970.1 ornithine aminotransferase -
  IRJ27_RS10385 rocE 2030871..2032274 (+) 1404 WP_003242721.1 amino acid permease -

Sequence

Protein


Download         Length: 400 a.a.        Molecular weight: 42788.56 Da        Isoelectric Point: 5.3354

>NTDB_id=442065 IRJ27_RS10360 WP_009969578.1 2026180..2027382(+) (htrA) [Bacillus subtilis strain N1303-2Ay]
MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPYLSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTK
IVSNMSPAVVGVVNIQKSDIWGESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL
AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVDSNGDGQPDWNAEVLQTDAAINP
GNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPSKLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPK
NVTNGAVVMGVDAFSPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKLSSADQLGS

Nucleotide


Download         Length: 1203 bp        

>NTDB_id=442065 IRJ27_RS10360 WP_009969578.1 2026180..2027382(+) (htrA) [Bacillus subtilis strain N1303-2Ay]
ATGGTGGATTACGAACGTGAGGAAGAACATACTACTCCTGAACAGCCAAAGAGAAGCAAAAAAGGATATTTTCTTTCGAG
TCTGATTGGCGTGATTGTCGGTGCCGTATTAATGGCGTTTATCATGCCGTACCTTTCAAATGAAGGGCTGGATACAGGCG
CCTTAGATCAGCAGCAAAACAACAATGGCCGGGAATCAATCAGGACGGTGAATGTCAGTGTCAACAATGCCGTCACCAAG
ATTGTCAGCAATATGTCGCCCGCCGTTGTCGGTGTTGTGAACATCCAAAAATCAGATATTTGGGGAGAGAGCGGCGAGGC
TGGGAGCGGCTCTGGCGTCATCTATAAGAAAAATGACCATTCCGCTTATGTCGTGACCAACCATCATGTCATCGAAGGCG
CTTCCCAAATTGAAATCAGCTTGAAAGACGGCTCACGTGTATCAGCTGATCTTGTCGGCAGCGACCAGCTGATGGACCTT
GCCGTTTTACGGGTGAAAAGCGATAAGATTAAAGCAGTCGCTGATTTCGGAAATTCAGATAAAGTGAAGTCTGGGGAGCC
GGTTATTGCGATCGGGAACCCGTTAGGCCTTGAGTTTGCAGGCTCTGTCACACAAGGCGTCATCTCGGGTACGGAGAGGG
CGATCCCAGTAGATTCAAACGGTGATGGACAGCCTGACTGGAACGCTGAAGTCCTGCAAACAGATGCGGCCATTAACCCT
GGGAACAGCGGCGGCGCTTTGTTAAATATGGATGGGAAGGTCATTGGCATCAATTCAATGAAAATTGCCGAGTCAGCGGT
TGAAGGGATTGGCCTGTCCATTCCGTCTAAGCTCGTGATCCCTGTGATAGAGGATTTAGAGAGATACGGAAAGGTCAAAC
GCCCGTTCCTTGGCATTGAGATGAAATCGCTAAGTGACATCGCAAGCTATCATTGGGATGAAACATTAAAGCTTCCTAAG
AACGTCACCAATGGAGCGGTTGTGATGGGTGTAGACGCCTTTTCACCTGCCGGAAAAGCGGGGCTGAAGGAACTGGATGT
CATCACGGAATTTGACGGATACAAAGTAAATGATATTGTTGACCTGCGAAAACGGCTTTATCAGAAAAAAGTCGGTGACC
GGGTGAAGGTGAAGTTTTATCGCGGCGGAAAAGAAAAATCTGTTGATATCAAGCTGTCCTCCGCAGACCAATTAGGCAGT
TAA

Domains

Predicted by InterProScan.

PDZ domain (PDZ_2)

(295-392)

Trypsin-like peptidase domain (Trypsin_2)

(110-257)

Peptidase family M50 (Peptidase_M50)

(203-395)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P39668

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

43.577

99.25

0.433
  htrA Streptococcus gordonii str. Challis substr. CH1

41.294

100

0.415
  htrA Streptococcus mitis NCTC 12261

42.746

96.5

0.412
  htrA Streptococcus pneumoniae TIGR4

44.848

82.5

0.37
  htrA Streptococcus pneumoniae D39

44.848

82.5

0.37
  htrA Streptococcus pneumoniae Rx1

44.848

82.5

0.37
  htrA Streptococcus pneumoniae R6

44.848

82.5

0.37