Detailed information NTG0044164

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: HMPREF1038_RS00525
• Genome accession: NC_018630
• Coordinates: 76333..78486 (+)
• Length: 717 a.a.
• NCBI ID: WP_000668301.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae gamPNI0373
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 71333..83486

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF1038_RS00485 (HMPREF1038_00100)	-	71685..72854 (+)	1170	WP_000366351.1	pyridoxal phosphate-dependent aminotransferase	-
HMPREF1038_RS00490 (HMPREF1038_00101)	recO	72851..73621 (+)	771	WP_000616164.1	DNA repair protein RecO	Machinery gene
HMPREF1038_RS00495 (HMPREF1038_00102)	plsX	73618..74610 (+)	993	WP_000717461.1	phosphate acyltransferase PlsX	-
HMPREF1038_RS00500 (HMPREF1038_00103)	-	74616..74849 (+)	234	WP_000136447.1	acyl carrier protein	-
HMPREF1038_RS00505 (HMPREF1038_00104)	-	74886..75185 (+)	300	Protein_92	transposase family protein	-
HMPREF1038_RS00510 (HMPREF1038_00105)	blpU	75388..75618 (+)	231	WP_001093075.1	bacteriocin-like peptide BlpU	-
HMPREF1038_RS13355 (HMPREF1038_00106)	-	75621..75746 (+)	126	WP_000346297.1	PncF family bacteriocin immunity protein	-
HMPREF1038_RS00525 (HMPREF1038_00107)	comA	76333..78486 (+)	2154	WP_000668301.1	peptide cleavage/export ABC transporter ComA	Regulator
HMPREF1038_RS00530 (HMPREF1038_00108)	comB	78499..79848 (+)	1350	WP_000801608.1	competence pheromone export protein ComB	Regulator
HMPREF1038_RS00535 (HMPREF1038_00109)	purC	80018..80725 (+)	708	WP_000043300.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HMPREF1038_RS13465	-	80736..80846 (+)	111	WP_078065395.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80366.39 Da
• Isoelectric Point: 6.2593

>NTDB_id=44164 HMPREF1038_RS00525 WP_000668301.1 76333..78486(+) (comA) [Streptococcus pneumoniae gamPNI0373]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPYKEQKNGLLSFIPI
LVKQRGLIANIVLATLLVTGINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGEMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=44164 HMPREF1038_RS00525 WP_000668301.1 76333..78486(+) (comA) [Streptococcus pneumoniae gamPNI0373]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCGGATATGACGCTTTTTGACTTGCCGGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCCGGGGTGAAGTTGACTAAACTGCCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTATAAGCCTTATAAGGAACAAAAAAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCGGGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTAGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTTACAGATGCTAACAGTATCATCGATGCGCTGGCTTCGACCATCCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTCTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTGCTTAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGAGATGACCTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTAACCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTTTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATGGCTTT
GGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTAGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterProScan.

• ABC transporter transmembrane region (ABC_membrane) (170-438)

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-650)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus pneumoniae Rx1	99.442	100	0.994
comA	Streptococcus pneumoniae D39	99.442	100	0.994
comA	Streptococcus pneumoniae R6	99.442	100	0.994
comA	Streptococcus pneumoniae TIGR4	99.024	100	0.99
comA	Streptococcus mitis SK321	98.466	100	0.985
comA	Streptococcus mitis NCTC 12261	98.326	100	0.983
comA	Streptococcus gordonii str. Challis substr. CH1	80.614	100	0.806
comA/nlmT	Streptococcus mutans UA159	64.575	100	0.646