Detailed information NTG0436168

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: HFV09_RS04490
• Genome accession: NZ_CP051138
• Coordinates: 898829..899665 (-)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain 4063-05
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 893829..904665

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HFV09_RS04470	-	894047..895039 (-)	993	WP_021299266.1	D-lactate dehydrogenase	-
HFV09_RS04475	-	895054..895620 (-)	567	Protein_824	PTS sugar transporter subunit IIC	-
HFV09_RS04480	-	895633..896517 (+)	885	Protein_825	LysR family transcriptional regulator	-
HFV09_RS04485	topA	896593..898722 (-)	2130	WP_011528644.1	type I DNA topoisomerase	-
HFV09_RS04490	dprA	898829..899665 (-)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
HFV09_RS04495	-	899730..900521 (-)	792	WP_011017771.1	ribonuclease HII	-
HFV09_RS04500	ylqF	900511..901359 (-)	849	WP_011017770.1	ribosome biogenesis GTPase YlqF	-
HFV09_RS04505	-	901578..902018 (+)	441	WP_011017769.1	DUF1836 domain-containing protein	-
HFV09_RS04510	-	902015..902665 (+)	651	WP_002984629.1	hemolysin III family protein	-
HFV09_RS04515	-	902782..903693 (+)	912	WP_011528643.1	diacylglycerol kinase family protein	-
HFV09_RS04520	-	903743..904177 (-)	435	WP_021299262.1	hypothetical protein	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=436168 HFV09_RS04490 WP_011017772.1 898829..899665(-) (dprA) [Streptococcus pyogenes strain 4063-05]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=436168 HFV09_RS04490 WP_011017772.1 898829..899665(-) (dprA) [Streptococcus pyogenes strain 4063-05]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367