Detailed information NTG0431290

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: HB750_RS09040
• Genome accession: NZ_CP050273
• Coordinates: 1852457..1853371 (-)
• Length: 304 a.a.
• NCBI ID: WP_019804618.1
• Uniprot ID: -
• Organism: Streptococcus mutans strain P1
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1847457..1858371

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HB750_RS09020 (HB750_09020)	-	1847840..1848223 (-)	384	WP_011074470.1	membrane protein	-
HB750_RS09025 (HB750_09025)	-	1848288..1848713 (-)	426	WP_002278431.1	low molecular weight protein-tyrosine-phosphatase	-
HB750_RS09030 (HB750_09030)	ruvB	1848751..1849746 (-)	996	WP_002284808.1	Holliday junction branch migration DNA helicase RuvB	-
HB750_RS09035 (HB750_09035)	-	1850081..1851922 (+)	1842	WP_002283787.1	carbohydrate-binding domain-containing protein	-
HB750_RS09040 (HB750_09040)	comR	1852457..1853371 (-)	915	WP_019804618.1	helix-turn-helix domain-containing protein	Regulator
HB750_RS09045 (HB750_09045)	-	1853756..1854442 (-)	687	WP_019804617.1	DNA alkylation repair protein	-
HB750_RS09050 (HB750_09050)	purB	1854462..1855760 (-)	1299	WP_002263398.1	adenylosuccinate lyase	-
HB750_RS09055 (HB750_09055)	-	1856106..1856915 (-)	810	WP_002283789.1	GyrI-like domain-containing protein	-
HB750_RS09060 (HB750_09060)	-	1856997..1857197 (-)	201	WP_024781816.1	hypothetical protein	-
HB750_RS09065 (HB750_09065)	-	1857295..1857987 (-)	693	WP_024781817.1	aspartate/glutamate racemase family protein	-

Sequence

Protein

• Length: 304 a.a.
• Molecular weight: 35290.45 Da
• Isoelectric Point: 5.0109

>NTDB_id=431290 HB750_RS09040 WP_019804618.1 1852457..1853371(-) (comR) [Streptococcus mutans strain P1]
MLKDFGKKIKSLRLEKGLTKEAVCLDESQLSTRQLTRIESGQSMPTLNKAIYIAGRLGVTLGYLTDGENVELPSRYKELK
YLLLRTPTYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVND
LILIDLYFSCLTVSGLDSAIFDSRKYNQLLETLLKQVDCLPLEDLFVLNNVLLNNFGLLLELKKYDFVKQLIAVSNKIMD
RTHDFQKKPIVNLLTWKHHLFVEKDYAKAKKSYDAAILFAQLTENINLRENLEKEWQKDSQNGT

Nucleotide

• Length: 915 bp

>NTDB_id=431290 HB750_RS09040 WP_019804618.1 1852457..1853371(-) (comR) [Streptococcus mutans strain P1]
ATGTTAAAAGATTTTGGGAAGAAAATTAAGAGCCTGAGGTTAGAAAAGGGGCTGACCAAAGAGGCTGTCTGCCTTGATGA
ATCGCAGTTGTCAACACGGCAGCTGACTAGAATTGAATCAGGACAGTCTATGCCAACTCTTAATAAAGCTATTTATATTG
CAGGACGTTTAGGAGTAACGCTTGGCTATTTAACGGACGGAGAAAATGTCGAGTTACCCAGTCGTTATAAAGAACTAAAG
TATTTATTATTACGAACGCCAACCTATGGCGATCAGCAAAGATTAGCCGAAAAAGAAACCTATTTTGACGAGATTTTTAG
TCAGTTTTATGATGATTTGCCTGAAGAAGAACAATTGATTATTGATGGCTTACAATCGAAACTAGATATTCATTTTAGTG
ACAATATCGATTTTGGCGTTGGTATTTTAAATGACTATTTTGATCAGATTTTAAGAAAAACCAATTATCAGGTCAATGAT
TTGATTCTGATTGATCTCTATTTTTCCTGCTTAACTGTTAGTGGTTTGGATTCAGCTATTTTTGATTCAAGAAAATATAA
TCAATTATTGGAGACATTGCTTAAGCAGGTAGACTGCCTTCCATTGGAAGATCTTTTCGTTTTAAATAATGTTTTATTGA
ATAATTTTGGACTCCTCTTAGAATTGAAAAAATATGATTTTGTTAAGCAGCTTATTGCTGTTAGCAATAAAATCATGGAT
AGAACTCATGATTTTCAAAAAAAGCCTATTGTTAATCTTCTGACATGGAAGCATCATTTATTTGTTGAAAAAGATTATGC
GAAAGCTAAAAAGAGCTATGATGCTGCTATCTTATTTGCCCAGTTAACAGAAAACATTAATTTAAGAGAAAATTTGGAGA
AAGAATGGCAAAAAGATTCTCAGAACGGGACATAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (9-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus mutans UA159	99.013	100	0.99
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	52.778	94.737	0.5
comR	Streptococcus pyogenes MGAS315	47.492	98.355	0.467
comR	Streptococcus pyogenes MGAS8232	47.02	99.342	0.467
comR	Streptococcus suis P1/7	43.478	98.355	0.428
comR	Streptococcus suis 05ZYH33	43.478	98.355	0.428
comR	Streptococcus suis D9	37	98.684	0.365